Comparison of Vitrectomy with Brilliant Blue G or Indocyanine Green on Retinal Microstructure and Function of Eyes with Macular Hole

Baba, Takayuki; Hagiwara, Akira; Sato, Eiju; Arai, Miyuki; Oshitari, Toshiyuki; Yamamoto, Shuichi

doi:10.1016/j.ophtha.2012.06.048

Cited by 80 publications

(52 citation statements)

References 28 publications

(25 reference statements)

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“…[12][13][14][15][16] Very recently a comparative study evaluating the microstructure of the inner and outer retina and visual function after macular hole surgery using brilliant blue or indocyanine green revealed that postoperative visual acuity and retinal sensitivity were better in eyes after BBG-assisted vitrectomy. 17 However, regardless which dyes the surgeon may choose for the surgical intervention, it has been reported that the stained ILM provides an increased rigidity and can be peeled off more easily and in larger fragments as compared with the unstained tissue. 15 Atomic Force Microscopy (AFM) is a well established examination technique that has been used to measure the thickness and rigidity of human ocular basement membranes such as the unstained ILM.…”

Section: Introductionmentioning

confidence: 99%

Vital dyes increase the rigidity of the internal limiting membrane

Haritoglou

Mauell

Benoit

et al. 2013

Eye

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Purpose To assess the stiffness of the natural human internal limiting membrane (ILM) and evaluate potential changes of the mechanical properties following staining with brilliant blue (BB) and indocyanine green (ICG). Methods Unstained ILM specimens were obtained during ophthalmic surgical procedures. After removal, the specimens were dissected into five parts. Two fragments were stained with BB and ICG, respectively, for 1 min, another two specimens were stained similarly followed by additional subsequent illumination using a standard light source (PENTA LUX x 50, Ophthalmologische Systeme GmbH Fritz Ruck). The fifth part served as an untreated control. All specimens were then analyzed using atomic force microscopy (AFM) in contact mode with a scan rate of 0.6 Hz. Two scan regions of 10 Â 10 mm were chosen and stiffness was determined by using AFM in a force spectroscopy mode. The force curves were plotted with a data rate of 5000 Hz. In all specimens both the retinal side and vitreal side were analyzed.

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Section: Introductionmentioning

confidence: 99%

Vital dyes increase the rigidity of the internal limiting membrane

Haritoglou

Mauell

Benoit

et al. 2013

Eye

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“…9 It was also showed by Baba et al that the GCC thickness was significantly reduced postoperatively in both the BBG group and the ICG group, however, the GCC thickness were not significantly different between the two groups at 3 and 6 months. 10 The above-mentioned studies differ in the measurement methods, but all supports an observation that ILM peeling may cause changes of retina, including GCC, thickness, which is apparently inconsistent with Sevim and Sanisoglu's observation.…”

mentioning

confidence: 74%

Retinal Ganglion Cell Complex Thickness after Internal Limiting Membrane Peeling for Idiopathic Macular Hole

Yan

Tong

2013

Current Eye Research

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“…In particular, this may impede the recovery of visual function during the first several months after MH surgery and may be responsible for the limited recovery of visual function during the early postoperative period. [19][20][21] In addition, we also postulate that this re-distribution of foveal tissue or attenuation of the central foveal tissue accompanied by the elongation of foveal tissue may have a negative effect on the anatomic stability of sealed MHs. This could be a potential cause of late re-opening of MH.…”

Section: Discussionmentioning

confidence: 95%