Comparison of Vitamin D Levels in Patients with and without Acne: A Case-Control Study Combined with a Randomized Controlled Trial

Lim, Seul-Ki; Ha, Ji-Hyang; Lee, Young-Ho; Lee, Young; Seo, Young‐Joon; Kim, Chang Deok; Lee, Jeung‐Hoon; Im, Myung

doi:10.1371/journal.pone.0161162

Cited by 68 publications

(98 citation statements)

References 27 publications

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“…This is in agreement with a previous study which found a decrease in the levels of 25 hydroxy vitamin D in patients with nodulocystic acne than that in the control group . Also, Lim et al found a significant lower vitamin D level in patients with acne than normal subjects. Vitamin D levels were inversely correlated with acne severity specially in patients with more inflammatory lesions.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Vitamin D levels in acne vulgaris patients treated with oral isotretinoin

El‐Hamd

Taieb

Ibrahim³

et al. 2018

J of Cosmetic Dermatology

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Section: Discussionsupporting

confidence: 92%

“…This is in agreement with a previous study which found a decrease in the levels of 25 hydroxy vitamin D in patients with nodulocystic acne than that in the control group. 19 Also, Lim et al 20…”

Section: Discussionmentioning

confidence: 98%

Vitamin D levels in acne vulgaris patients treated with oral isotretinoin

El‐Hamd

Taieb

Ibrahim³

et al. 2018

J of Cosmetic Dermatology

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“…Lim et al demonstrated that vitamin D deficiency is more common in acne patients as compared with controls. 7 Yıldızgören et al demonstrated that serum levels of vitamin D was lower in patients with nodulocystic acne than that of the control group. 6 In the same study, it was hypothesized that vitamin D deficiency may contribute to development of comedones due to its role in the process of proliferation and differentiation of keratinocytes and sebocytes.…”

Section: Discussionmentioning

confidence: 99%

“…6 It also affects the proliferation and differentiation of keratinocytes and sebocytes. 7 Based on these characteristics of vitamin D, it has been hypothesized that there may be a link between the pathophysiology of acne and vitamin D.…”

mentioning

confidence: 99%

Serum Levels of 25-Hydroxyvitamin-D and C-Reactive Protein in Acne Vulgaris Patients

Karabay¹,

Çerman²

2019

Turkiye Klinikleri J Dermatol

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cne vulgaris (AV), disease of the pilosebaceous unit, is characterized by inflammatory and non-inflammatory lesions, presented as comedones, papules, pustules, and nodules. 1 Many factors contribute to the development of AV, including hormones, follicular pluggings and hyperkeratinization of follicles, increase in the levels of sebum secretion, Propionibacterium acnes (P. acnes) colonization, and inflammation. [1][2][3][4] In the acne follicle infiltration of CD4+ T cells and T helper (Th) 1 cytokine profile has been shown which is thought to be a cellular response 1 Serum Levels of 25-Hydroxyvitamin-D and C-Reactive Protein in Acne Vulgaris Patients A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Acne vulgaris is a disease of pilosebaceous unit. Although multiple factors contribute to the development of acne, inflammation is the key component in the pathogenesis. Creactive protein (CRP) is a well-known marker of inflammation and there are few reports studying the antioxidant, and anti-inflammatory effects of vitamin D in acne. In the present study, the aim was to compare serum vitamin D and CRP levels in acne patients with control subjects. M Ma at te e-r ri ia al l a an nd d M Me et th ho od ds s: : 65 patients with acne vulgaris, and 41 healthy subjects were enrolled in this crosssectional study. Serum vitamin D and CRP levels of both groups were evaluated. R Re es su ul lt ts s: : No significant association was found between the occurence of acne vulgaris and serum 25-hydroxyvitamin D and CRP levels (p=0.692, p=0.300, respectively). C Co on nc cl lu us si io on n: : Vitamin D deficiency was determined to be equivalent in both acne patients and healthy subjects. This result might be due to the affection of the whole Turkish population with the same problem. Larger size studies which investigate the status of vitamin D levels in patients with acne, could provide making more precise interpretations. K Ke ey yw wo or rd ds s: : Acne vulgaris; c-reactive protein; inflammation; vitamin D Ö ÖZ ZE ET T A Am ma aç ç: : Akne vulgaris pilosebase ünitenin bir hastalığıdır. Akne gelişimine pek çok faktör katkıda bulunsa da, inflamasyon patogenezdeki ana bileşendir. C-reaktif protein (CRP) iyi bilinen bir inflamatuar belirteçtir ve vitamin D'nin aknedeki antioksidan ve antiinflamatuar etkilerini inceleyen birkaç çalışma bulunmaktadır. Bu çalışmanın amacı akne hastaları ile kontrol grubu arasında serum vitamin D ve CRP düzeylerini karşılaştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : 65 akne vulgaris ve 41 sağlıklı kontrol kişileri bu kesitsel çalışmaya dâhil edilmiştir. Her iki grupta da serum vitamin D ve CRP düzeyleri değerlendirilmiştir. B Bu ul lg gu ul la ar r: : Akne vulgaris varlığı ile serum 25-hidroksi-vitamin D ve CRP düzeyleri arasında bir ilişki gösterilememiştir (p=0,692, p=0,300, sırasıyla). S So on nu uç ç: : Vitamin D eksikliğinin hem akne hem de kontrol grubunda eşit olarak bulunması, bu sorunun tüm Türkiye popülasyonunu ekileyen genel bir problem olmasına bağlanabilir. Akne hast...

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“…www.nature.com/scientificreports www.nature.com/scientificreports/ compared to the healthy controls [26][27][28] . Yildizgören et al evaluated a total of 43 patients with newly diagnosed nodulocystic acne and 46 healthy control subjects according to their 25 OH D levels 27 .…”

Section: Discussionmentioning

confidence: 99%

Effect of Serum 25 Hydroxy Vitamin D Level on Isotretinoin-Induced Musculoskeletal Symptoms: A Cross-Sectional Study

Mülkoğlu

Karaosmanoğlu

2020

Sci Rep

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Isotretinoin (ISO) is a drug which is used for the treatment of severe and refractory acne vulgaris (AV), over the last few decades. The drug has various musculoskeletal side effects. The aim of this study was to investigate relationship between serum 25 hydroxy (OH) vitamin D levels and the ISOinduced musculoskeletal side effects in patients with AV. We included 87 patients receiving ISO and had musculoskeletal symptoms as adverse effect (AE) group. Another 90 patients receiving ISO for AV and had any musculoskeletal complaints were recruited as control (C) group. Locomotor system examination of the patients was performed by the same clinician. Serum 25 OH vitamin D levels of the all participants were measured. Patients in the AE group were divided into three subgroups by serum 25 OH vitamin D levels. Patients with serum 25 OH vitamin D level lower than 10 ng/ml was classified as Group I, the ones between 10-20 ng/ml as Group II and those higher than 20 ng/ml were classified as Group III. AE and C groups were similar in terms of age and sex (p > 0.05). There was no statistically significant difference in the mean serum vitamin D levels between two groups (p = 0.17). Also, there was no significant difference in number of arthralgia (p = 0.30), myalgia (p = 0.29), low back pain (p = 0.10) and sacroiliitis (p = 0.17) between three subgroups in AE group. In addition, we found no statistically significant correlation between the serum vitamin D levels and age, cumulative dose of ISO, arthralgia, myalgia and sacroiliitis parameters in AE group (p > 0.05). Serum 25 OH vitamin D levels between the AE and C groups were similar. We also found that no significant difference in musculoskeletal adverse events between AE subgroups. Therefore, it can be concluded that vitamin D deficiency has no effect on the musculoskeletal adverse events in patients receiving ISO.

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Comparison of Vitamin D Levels in Patients with and without Acne: A Case-Control Study Combined with a Randomized Controlled Trial

Cited by 68 publications

References 27 publications

Vitamin D levels in acne vulgaris patients treated with oral isotretinoin

Vitamin D levels in acne vulgaris patients treated with oral isotretinoin

Serum Levels of 25-Hydroxyvitamin-D and C-Reactive Protein in Acne Vulgaris Patients

Effect of Serum 25 Hydroxy Vitamin D Level on Isotretinoin-Induced Musculoskeletal Symptoms: A Cross-Sectional Study

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