Comparison of vitamin D (25OHD) status between fertile and infertile men

Nasreen, Khaleda; Ishrat, Shakeela; Banu, Jesmine; Fatima, Parveen; Ansary, Selina Afroz; Jahan, Israt; Afrin, Shanta; Karim, Mohammad Rezaul; Islam, Mansurul

doi:10.18203/2320-1770.ijrcog20211104

Cited by 5 publications

(5 citation statements)

References 17 publications

(18 reference statements)

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“…Regarding this indicator, our results are in agreement with the results of other authors who reported a significant decrease in total 25OHD levels in men with abnormal spermogram compared to men with normozoospermia (Holzer et al, 2022; Islam et al, 2022). A few studies did not find a significant difference in the total 25OHD levels between fertile and infertile men (Nasreen et al, 2021).…”

Section: Discussionsupporting

confidence: 48%

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Effect of vitamin D metabolites and gene expression of vitamin D receptor, and 1‐alpha‐hydroxylase related to the sperm quality

Roussev,

Salim,

Nenkova

et al. 2023

Reprod Domestic Animals

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The incidence of male fertility disorders has increased greatly due to various genetic and lifestyle factors. Recently, it has been hypothesized that vitamin D may be involved with idiopathic infertility. The goal of the study was to determine the effect and relationship between blood vitamin D metabolites, intracellular sperm vitamin D levels, and gene expression of 1‐α‐hydroxylase and VDR, with regard to semen quality. Seventy volunteers aged 25–45 were involved in the study. According to spermogram analysis, participants were stratified into normozoospermic control group, non‐normozoospermic target group, and oligoasthenoteratozoospermic group. Vitamin D metabolites (total 25‐hydroxycholecalciferol, 1,25‐dihydroxycholecalciferol) in blood and spermatozoa were determined by ELISA. Free and bioavailable 25‐hydroxycholecalciferol were calculated using the Vermeulen equation. mRNA expression of VDR and 1‐α hydroxylase was evaluated by qPCR. Free and bioavailable 25‐hydroxycholecalciferol were significantly higher in the control group compared to the target group and compared to the oligoasthenoteratozoospermic group . Intracellular sperm 1,25‐dihydroxycholecalciferol was higher in the control group compared to the target group. The mRNA levels of 1‐ α‐hydroxylase were significantly higher in the control samples, while VDR expression was significantly higher in the target group. Significant positive correlations were established between free and bioavailable 25‐hydroxycholecalciferol with sperm motility and morphology. Vitamin D metabolites in blood and intracellular sperm 1,25‐dihydroxycholecalciferol seem to exert beneficial effects on sperm motility and morphology. Regarding sperm quality, these effects are more pronounced in the free and bioavailable 25OHD compared to the total 25OHD in blood. Higher expression of 1‐α‐hydroxylase likely leads to higher intracellular levels of 1,25‐dihydroxycholecalciferol, which could contribute to sperm motility and morphology. Higher VDR expression may be a compensatory mechanism related to lower intracellular sperm 1,25‐dihydroxycholecalciferol.

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Section: Discussionsupporting

confidence: 48%

“…Studies about the effect of the free and bioavailable 25OHD A few studies did not find a significant difference in the total 25OHD levels between fertile and infertile men (Nasreen et al, 2021).…”

Section: F I G U R E 1 Comparison Of Gene Expression Levels Of Cyp27b1mentioning

confidence: 99%

Effect of vitamin D metabolites and gene expression of vitamin D receptor, and 1‐alpha‐hydroxylase related to the sperm quality

Roussev,

Salim,

Nenkova

et al. 2023

Reprod Domestic Animals

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“…Data obtained show that vitamin D level defines ejaculate amount and quality in men [44,45] (including sperm cells motility and their morphology [46,47]), and ripening of spermatozoon. The correlation between low concentration of vitamin D and increased quantity of motile and morphologically normal sperms has been determined.…”

Section: оглядиmentioning

confidence: 99%

FERTILITY FACTORS. D-HORMONE IN PREVENTION OF REPRODUCOPATHIES CAUSED BY BENIGN PROSTATIC HYPERPLASIA (Literature review)

Koreneva,

Bondarenko,

Brechka

et al. 2023

PEP

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In accordance with the statistical data, the spreading of benign prostatic hyperplasia (BPH) is increasing, because modern stressful lifestyle causes sex hormones disbalances and other dyshormonal conditions which lead to pathologies’ development at younger ages. The pathogenesis of BPH is connected with disturbances of regulation in the hypothalamo-hypophyseal system and with the changes of the regulatory signals intensity which go to the reproductive organs. The central pathogenic links of this pathology’ development are: the declining of efficacy of hypothalamus functioning regulation which carries out on the basis of feedback; the changes of the pituitary gland cells sensitivity to the releasing hormones of hypothalamus and disbalance of sex hormones. In addition to gonadotropins prolactin has a significant impact on the BPH development. Its hypersecretion causes the development of hyperplastic age-related changes in prostate gland. The introduction of dopamine receptors antagonists such as sulpiride causes the increasing of prolactin concentration and declining of gonadotropins releasing. “Sulpiride model” is broadly used in the experimental endocrinology for studying prostate-active drugs and is characterized by sex hormones disbalance' and inflammation processes’ development. The development of the pathology is linked with the disturbance of testosterone synthesis in the testicles, insufficiency of prostate gland functioning and increasing of prolactin and estradiol concentrations which provoke proliferative changes. The androgens disbalance is the main cause of BHP development, therefore, the “Testosterone model” based on testosterone’ and estradiol’ slow releasing implants is broadly used for modeling of urination disturbance in rats which imitates the same condition in elderly men with benign prostatic hyperplasia. The prostatitis, which developed under the condition of BHP, causes the disturbances of spermatogenesis during experimental modeling and in the clinical practice when spermatopathies, sexual disturbances and hypofertility are diagnosed in patients. The traditional BHP therapeutic methods are not always effective and the new therapeutic approaches of hypofertility caused by prostate gland pathologies are developed by investigators. Thus, there are data about correlation between increased vitamin D consumption and decreasing of BHP spreading, between gland volume and cells proliferation in patients with this pathology. Vitamin D level influences the quantity and quality of ejaculate. The deficiency of vitamin D is associated with lower proportion of sex hormones in young men and choriogonin sensitivity of Leydig's cells to be diminished. It has been experimentally shown that cholecalciferol regulates steroid hormones genesis, mitigates the age-related declining of testicles activity, protects the testicles in old animals and the unchanged spermatogenesis in normal males which received vitamin D3 can be considered to be the result of estrogens and androgens balance. The androgens receptors as well as vitamin D receptors have been found in prostate gland in health males and in those with hyperplasia. In addition to its classical function in calcium homeostasis and bones health, vitamin D inhibits tumor growth in different tissues including prostate gland. Vitamin D metabolites have been determined to be anti-inflammatory, proapoptotic and antiproliferative. D-hormone application potentiates the specific properties of prostate gland protectors, recovers reproductive capacity under the condition of experimental chronic prostatitis of inflammatory genesis as well as traumatic. All facts listed above allow to confirm the positive role of D-hormone in the regulation of prostate gland and reproductive function in patients with BHP and recovering of fertility under the condition of this pathology. The literature search for this review has been carried out on databases PubMed, Science Direct, Europa PMC, BMC, MedLine etc.

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“…Poor serum 25-hydroxyvitamin D concentrations (25(OH)D) have been detected among young infants as well as pregnant women in Bangladesh, advised to have Vit D supplementation 6 . In Bangladesh, 86% of people have hypovitaminosis D; 61.4% have a deficiency and 24.1% have insufficiency 7 . Symptoms and signs of Vit-D deficiencies are fatigue, bone pain, muscle weakness, joint pain, etc.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Vitamin D Deficiency among Patients Attending Tertiary Level Hospitals in Bangladesh: Hospital-Based Cross-Sectional Study

Islam Majumder,

Rahman,

Ahmed

et al. 2024

Med. Today

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Introduction: Vitamin D (Vit D) is essential for calcium and phosphate homeostasis, critical for bone growth and remodeling. Its deficiency leads to conditions like osteomalacia and rickets, with adverse effects on osteoporosis, growth, and skeletal health. This study aimed to assess Vitamin D Deficiency prevalence among patients in Bangladeshi tertiary-level hospitals. Materials and Methods: A prospective cross-sectional study was conducted from January to December 2019 at Cumilla Medical College Hospital and Central Medical College Hospital. We enrolled 1250 patients meeting inclusion criteria and collected data via a pre-designed questionnaire. Results: Most participants (31.8%) were aged 31-40, with a mean age of 37.31±13.37. Male patients constituted 53.3%, and 46.7% were female. Rural residents accounted for 52.6%, while 25.8% lived in urban areas, and the rest abroad, mainly the Middle East. The majority (88.5%) belonged to middle-class families, and only 1.5% reported sufficient sun exposure. Strikingly, 54.2% were Vitamin D deficient, 40% had insufficient levels, and only 6.4% had adequate Vit D. Conclusion: This study highlights a significant prevalence of Vitamin D deficiency among patients in Bangladeshi tertiary hospitals. The data underscore the urgent need for healthcare authorities to address this public health concern. Policymakers and healthcare providers should be aware of the potential long-term health consequences of Vitamin D deficiency, emphasizing the importance of strategies to promote adequate Vit D levels in the population. Medicine Today 2023 Vol.36 (1): 17-22

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Comparison of vitamin D (25OHD) status between fertile and infertile men

Cited by 5 publications

References 17 publications

Effect of vitamin D metabolites and gene expression of vitamin D receptor, and 1‐alpha‐hydroxylase related to the sperm quality

Effect of vitamin D metabolites and gene expression of vitamin D receptor, and 1‐alpha‐hydroxylase related to the sperm quality

FERTILITY FACTORS. D-HORMONE IN PREVENTION OF REPRODUCOPATHIES CAUSED BY BENIGN PROSTATIC HYPERPLASIA (Literature review)

Prevalence of Vitamin D Deficiency among Patients Attending Tertiary Level Hospitals in Bangladesh: Hospital-Based Cross-Sectional Study

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