Comparison of Visual Inspection Methods Using Either Acetic Acid Solution or Lugol’s Iodine Solution with Colposcopy in Screening of Cervical Cancer: A Cross Sectional Study

Tehranian, Afsaneh; Ghahghaei-Nezamabadi, Akram; Langeroudi, Maryam Motiei; Aghajani, Reyhaneh

doi:10.30699/jogcr.8.1.53

Cited by 2 publications

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“…The reproductive system of a woman consists of the cervix, uterus, vagina, and ovaries. Cervical cancer develops at the vaginal entrance to the uterus 8 . Cervical cancer is commonly caused by sexually transmitted human papillomavirus (HPV) and is more common in poor and middle-income nations 9 .…”

Section: Discussionmentioning

confidence: 99%

Accuracy of Cervical Intraepithelial Lesion Diagnosis by Visual Cervical Examination with Acetic Acid

Latif¹,

Bibi²,

Ghafoor³

et al. 2023

PJMHS

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Introduction: Using acetic acid to inspect the vaginal canal is a simple screening procedure done with the naked eye. During a speculum examination, the cervical transformation zone is painted with acetic acid 3% to 5% or vinegar. It is a simple, cost-effective screening tool that can be used in poor developing countries with high rates of invasive cervical cancer mortality because acetic acid coagulates nuclear proteins, resulting in white discoloration of the transformation zone in CIN and early invasive cancer. Objective: This study aims to measure the effectiveness of a simple and economical screening test, visual inspection with acetic acid (VIA), for diagnosing cervical intraepithelial lesions in comparison to the gold standard of histopathology using a study population of women attending a gynecology outpatient department. Study Design: The study used a cross-sectional design to validate the findings. Study Area: This study was conducted in the Obstetrics & Gynecology Department, Women and Children Teaching Hospital, Dera Ismail Khan. Study Duration: This study took place between November 2018 and April 2019. Materials and Methods: The study included 414 women with abnormal vaginal bleeding. Under a good light source, a lubricated Cusco's speculum was introduced into the vagina to evaluate the cervix for gross abnormalities. A cotton swab was used to apply 3% acetic acid to the cervix and acetowhite changes were observed for one minute. Positive results were considered when distinct acetowhite areas were detected, while negative results were considered when light, faint, or doubtful aceto-white areas were detected. Results: There was a range of age from 18 to 40 years in this study with a mean age of 30.772 years and a mean weight of 71.644 kilograms. For diagnosis of cervical intraepithelial lesions, acetic acid visual examination has shown a sensitivity of 84.38%, specificity of 97.11%, diagnostic accuracy of 95%, PPV of 84.38%, and NPV of 97.11% (p=0.000). Practical implication: The purpose of this study is to compare the efficacy of a simple and inexpensive screening test, visual inspection with acetic acid (VIA), to the gold standard of histopathology in a study group of women attending a gynecological outpatient service. Cervical cancer is a leading cause of death among women in developing countries, where access to advanced diagnostic tools is limited. If VIA proves to be an effective screening tool, it could be widely implemented in low-resource settings to improve early detection and treatment of cervical cancer. Conclusion: VIA is considered an appropriate screening alternative for a large population. In contrast to cytology-based programs, it is highly sensitive, low-cost, and yields immediate results. Keywords: Cervical Cancer; Visual Inspection with Acetic Acid; Screening

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Section: Discussionmentioning

confidence: 99%

Accuracy of Cervical Intraepithelial Lesion Diagnosis by Visual Cervical Examination with Acetic Acid

Latif¹,

Bibi²,

Ghafoor³

et al. 2023

PJMHS

View full text Add to dashboard Cite

show abstract

“…Cervical cancer is the fourth most common cancer of women in the world and the second in low- and middle-income countries ( 1 ). The diagnosis of high-grade cervical intraepithelial neoplasia (CIN) is undeniably considered a precursor to malignant cervical cancer ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Random Biopsy and Endo-Cervical Curettage in Diagnosis of Precancerous Cervical Lesions in Women With Normal Colposcopy

Ghahghaei-Nezamabadi,

Tehranian,

Feizabad

et al. 2024

JFRH

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Objective: This study aimed to evaluate the effect of random biopsy and endo-cervical curettage (ECC), alone and together, in the diagnosis of high-grade cervical lesions in women with normal colposcopy. Materials and methods: This cross-sectional study was conducted on 356 women who underwent colposcopy examination in the gynecology-oncology clinic of Roointan-Arash Women’s Hospital, affiliated with Tehran University of Medical Sciences. All eligible women underwent colposcopy. In colposcopy examination, up to four biopsy samples were randomly taken for each quartile of the cervix and ECC was performed. Finally, the rate of intraepithelial neoplasia (CIN) and the relation between random biopsy and ECC and CIN diagnosis was determined. Results: In total, 27 (7.6%) low-grade squamous intraepithelial lesions (LSIL) and 19 (5.3%) high-grade squamous intraepithelial lesions (HSIL) were detected in cases that underwent random biopsy. There was a significant association between the abnormal random biopsy results and having multiple sexual partners (p=0.001), cigarette (p=0.041), and hookah (p=0.033) smoking. Furthermore, 31 (8.7%) LSIL and 42 (11.8%) HSIL were reported in women who underwent ECC. There was a significant relation between the abnormal results of ECC and hookah consumption (p=0.008) and human papillomavirus (HPV) infection (p=0.011). The concordance (p=0.001) between random biopsy and ECC result was 71.2% and only in 28.8% of the cases one of the methods was normal and the other was abnormal. Conclusion: The present study showed that the simultaneous use of ECC and random biopsy in women with normal colposcopy increases the detection rate of precancerous lesions by up to 28.8%.

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Comparison of Visual Inspection Methods Using Either Acetic Acid Solution or Lugol’s Iodine Solution with Colposcopy in Screening of Cervical Cancer: A Cross Sectional Study

Cited by 2 publications

References 0 publications

Accuracy of Cervical Intraepithelial Lesion Diagnosis by Visual Cervical Examination with Acetic Acid

Accuracy of Cervical Intraepithelial Lesion Diagnosis by Visual Cervical Examination with Acetic Acid

The Effect of Random Biopsy and Endo-Cervical Curettage in Diagnosis of Precancerous Cervical Lesions in Women With Normal Colposcopy

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