Comparison of Virulence Patterns Between Streptococcus uberis Causing Transient and Persistent Intramammary Infection

Srithanasuwan, Anyaphat; Pangprasit, Noppason; Suriyasathaporn, Witaya

doi:10.3389/fvets.2022.806674

Cited by 5 publications

(3 citation statements)

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“…The lactoferrin was thought to facilitate the inhibition of bacteria-iron binding [34]. Moreover, the proliferation of lymphocyteinduce mitogen and alloantigen, and the inhibition of bovine mammary epithelial cell (MAC-T cells) proliferation were allowed by lactoferrin [35,36]. During the involution period of a cow, lactoferrin will be excessively produced, likewise in the infected udder [37].…”

Section: Lactoferrin-binding Proteinmentioning

confidence: 99%

“…Streptococcus is believed to be more insusceptible to the antimicrobial effects of lactoferrin since it has a minimum necessity of iron [38,39] or maybe due to the ability to extort the metal component other protein comprising iron [40]. Undeniably, several species of streptococcus express the lactoferrin-binding proteins, i.e., S. uberis, S. agalactiae, and S. dysgalactiae, implying an objective of lactoferrin with streptococcal infections which may have a crucial indication for Intra Mammary dysgalactiae streptolysin S, glyceraldehyde-3phosphate dehydrogenase, the plasminogen-binding Mlike protein PAM, and the collagen-like protein SclB, GAS bacteriophage-associated virulence genes encoding superantigens, DNase, and/or streptodornase, cfb, lmb, eno, napr, bca, scpB, cyl [32,33] uberis hasA, hasB, hasC, sua, gapC, lbp, pauA, oppF, mtuA, CAMP factor or cfu [34,35] Infection (IMI) pathogenesis [10]. However, there is a distinction in lactoferrin-binding protein molecular mass among streptococcus due to the diversity of their surface characteristic [41].…”

Section: Lactoferrin-binding Proteinmentioning

confidence: 99%

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Mini Review: Lactoferrin-binding protein of Streptococcus in Bovine Mastitis

et al. 2022

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Bovine mastitis is an udder inflammation mostly found in dairy cattle that causes enormous economic losses. Streptococcus is a bacterium that is often found in mastitis, including Streptococcus agalactiae, Streptococcus dysgalactiae, and Streptococcus uberis. These three species have lactoferrinbinding protein (LBP) as one of their virulence factors. Lactoferrin is a host innate immune protein that acts as antibacterial, immunomodulator, anti-adhesion, and has iron-binding properties. The LBP on the surface of Streptococcus could bind to lactoferrin produced by host cells. Uniquely, the three Streptococcus bacteria showed different responses to lactoferrin. The lactoferrin-LBP bound on S. agalactiae and S. dysgalactiae was known to inhibit their penetration ability into the host epithelial cells, on the contrary, in S. uberis it could enhance their ability to invade the cells. This paper aims to review the role of the lactoferrin-binding protein of Streptococcus in bovine mastitis.

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Section: Lactoferrin-binding Proteinmentioning

confidence: 99%

Section: Lactoferrin-binding Proteinmentioning

confidence: 99%

Mini Review: Lactoferrin-binding protein of Streptococcus in Bovine Mastitis

In Vitro Bacterial Competition of Staphylococcus aureus, Streptococcus agalactiae, and Escherichia coli against Coagulase-Negative Staphylococci from Bovine Mastitis Milk

et al. 2023

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Intramammary infection (IMI) from the environment and infected quarters can cause co-infection. The objective of this study was to determine the ability of coagulase-negative staphylococci (CNS) to survive in the same environment as Staphylococcus aureus, Streptococcus agalactiae, and Escherichia coli as major pathogens. In total, 15 and 242 CNS strains were used in Experiment I and Experiment II, respectively. Both experiments were separated into three conditions: culture with CNS 24 h before (PRIOR), after (AFTER), and at the same time (EQUAL). The lack of a clear zone, regardless of size, was determined to be the key to the survival of both. The CNS species’ percentages of survival against major pathogens were tested using Fisher’s exact test. Differences in the percentages of survival were evident among the CNS species in all conditions. For the PRIOR condition, all CNS mostly survived when living with major strains; however, S. chromogenes could degrade S. agalactiae. Although most CNS strains were degraded in the AFTER and EQUAL conditions, some strains of S. hominis and S. simulans could resist S. aureus and S. agalactiae. In conclusion, some specific strains of CNS are able to survive in an environment with major pathogens. Research into the survival strains may indicate that the concept of novel bacteria with bacteriolytic capabilities might be possible as a novel mastitis treatment.

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