Comparison of virtual microscopy and glass slide microscopy among dermatology residents during a simulated in‐training examination

Brick, Katherine E.; Sluzevich, Jason C.; Cappel, Mark A.; DiCaudo, David J.; Comfere, Nneka I.; Wieland, C

doi:10.1111/cup.12189

Cited by 30 publications

(33 citation statements)

References 24 publications

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“…[4][5][6] Implementation barriers include the cost-benefit of digital pathology, current lack of regulatory approval from the US Food and Drug Administration, a paucity of evidence validating the diagnostic concordance of WSI and light microscopy, and low acceptability of digital pathology among pathologists. 1,[7][8][9][10][11] If digital pathology is to be implemented for primary diagnosis on a large scale, regulatory bodies, both international and national; departmental heads; and individual pathologists will have to be confident that a diagnosis made on a digital microscope is equivalent to a diagnosis made by the same pathologist on a light microscope.…”

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confidence: 99%

A Systematic Analysis of Discordant Diagnoses in Digital Pathology Compared With Light Microscopy

Williams¹,

DaCosta²,

Goacher³

et al. 2017

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Relatively little is known about the significance and potential impact of glass-digital discordances, and this is likely to be of importance when considering digital pathology adoption.Objective.-To apply evidence-based medicine to collect and analyze reported instances of glass-digital discordance from the whole slide imaging validation literature.Design.-We used our prior systematic review protocol to identify studies assessing the concordance of light microscopy and whole slide imaging between 1999 and 2015. Data were extracted and analyzed by a team of histopathologists to classify the type, significance, and potential root cause of discordances.Results.-Twenty-three studies were included, yielding 8069 instances of a glass diagnosis being compared with a digital diagnosis. From these 8069 comparisons, 335 instances of discordance (4%) were reported, in which glass was the preferred diagnostic medium in 286 (85%), and digital in 44 (13%), with no consensus in 5 (2%). Twenty-eight discordances had the potential to cause moderate/severe patient harm. Of these, glass was the preferred diagnostic medium for 26 (93%). Of the 335 discordances, 109 (32%) involved the diagnosis or grading of dysplasia. For these cases, glass was the preferred diagnostic medium in 101 cases (93%), suggesting that diagnosis and grading of dysplasia may be a potential pitfall of digital diagnosis. In 32 of 335 cases (10%), discordance on digital was attributed to the inability to find a small diagnostic/prognostic object.Conclusions.-Systematic analysis of concordance studies reveals specific areas that may be problematic on whole slide imaging. It is important that pathologists are aware of these areas to ensure patient safety.

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confidence: 99%

A Systematic Analysis of Discordant Diagnoses in Digital Pathology Compared With Light Microscopy

Williams¹,

DaCosta²,

Goacher³

et al. 2017

Archives of Pathology &Amp; Laboratory Medicine

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“…Variation may also depend on level of experience and familiarity with DS. One study found that accuracy with virtual microscopy is dependent on year of residency training and prior experience with virtual microscopy . Further study may be necessary to understand what degree resolution and other facets of digitization including user familiarity of the digitized slides impact the identification of histopathologic features.…”

Section: Discussionmentioning

confidence: 99%

Feasibility study in teledermatopathology: An examination of the histopathologic features of mycosis fungoides and spongiotic dermatitis

et al. 2017

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“…Several initiatives, such as the European Association of Pathology Chairs and Residency Program Directors, aim to homogenize the knowledge of residents all over Europe evaluating them by performing a test containing virtual slides [17]. WSI is well evaluated by residents in the studies, although the final results comparing abilities reached with WSI and CLM differ from one study to another [43,44,45]. The presence of clinical and radiological information and previous practice using WSI seem to influence the results [36].…”

Section: Wsi In Postgraduate Training (Residency and Fellowship Progrmentioning

confidence: 99%

Current Status of Whole-Slide Imaging in Education

et al. 2016

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Conventional light microscopy (CLM) has classically been the basic tool to teach histology and pathology. In recent years, whole-slide imaging (WSI), which consists of generating a high-magnification digital image of an entire histological glass slide, has emerged as a useful alternative to CLM offering a myriad of opportunities for education. Navigation through the digitized slides closely simulates viewing glass slides with a microscope and is also referred to as virtual microscopy. WSI has many advantages for education. Students feel more comfortable with its use, and it can be used in any classroom as it only requires a computer with Internet access and it allows remote access from anywhere and from any device. WSI can be used simultaneously by a large number of people, stimulating cooperation between students and improving the interaction with the teachers. It allows making marks and annotations on specific fields, which enable specific directed questions to the teacher. Finally, WSI supports are cost-effective compared with CLM. Consequently, WSI has begun to replace CLM in many institutions. WSI has shown to be an extremely useful tool for undergraduate education (medical, dental and veterinary schools), for the training of residents of pathology, tele-education and in tumor boards.

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Comparison of virtual microscopy and glass slide microscopy among dermatology residents during a simulated in‐training examination

Abstract: Diagnostic accuracy with virtual microscopy is dependent on year of residency training and prior experience with virtual microscopy.

Cited by 30 publications

References 24 publications

A Systematic Analysis of Discordant Diagnoses in Digital Pathology Compared With Light Microscopy

A Systematic Analysis of Discordant Diagnoses in Digital Pathology Compared With Light Microscopy

Feasibility study in teledermatopathology: An examination of the histopathologic features of mycosis fungoides and spongiotic dermatitis

Current Status of Whole-Slide Imaging in Education

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