Comparison of vessel density in macular and peripapillary regions between primary open-angle glaucoma and pseudoexfoliation glaucoma using OCTA

Subaşı, Sevgi; Yüksel, Nurşen; Basaran, Ece; Pirhan, Dilara

doi:10.1007/s10792-020-01564-5

Cited by 12 publications

(13 citation statements)

References 25 publications

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“…Due to the fact that our comparable OCTA data is supported by the Image J data, we assume that the peripapillary vascular deficit in PXG and POAG does not differ quantitatively in eyes with comparable glaucoma severity. This is supported by further studies [ 12 , 14 , 18 ].…”

Section: Discussionsupporting

confidence: 80%

“…Rebolleda et al [ 16 ], who also used AngioPlex to examine peripapillary vascular parameters, were unable to determine any peripapillary vessel density differences with AngioPlex, while significant reductions in many peripapillary vascular parameters could be demonstrated using another OCTA device (AngioVue). Regarding the size of the FAZ, Köse et al [ 13 ] demonstrated a larger FAZ size for PXG than for POAG, while there were no significant differences in other studies [ 12 , 17 ].…”

Section: Discussionmentioning

confidence: 95%

“…In addition to the studies using OCTA to determine a quantitative difference in vessel density in the peripapillary plexus between PXG and POAG in terms of vascular reduction in PXG patients [ 13 , 15 ], there were other studies [ 12 , 14 , 18 ], such as ours, that could not determine any quantitative difference in vessels in the peripapillary vascular plexus.…”

Section: Discussionmentioning

confidence: 97%

“…Differences in perfusion density (PD) in glaucomatous eyes, more precisely reduced macular, peripapillary and papillary vascular densities compared to healthy eyes, have been demonstrated by OCTA [4][5][6]8]. The OCTA also shows the presence of an enlarged perimeter of the FAZ with reduced circularity in glaucomatous eyes compared to healthy eyes, while no difference could be found in the size of the FAZ [10][11][12]. Since vascular dysfunction plays an important role in the pathogenesis of glaucoma disease, studies have focused on the different manifestations of vascular dysfunction in the different entities of glaucoma.…”

Section: Introductionmentioning

confidence: 99%

“…In this regard, various questions about the blood flow situation in primary open-angle glaucoma (POAG) and pseudo-exfoliation glaucoma (PXG) have been investigated using different OCTA devices. Uniform results regarding differences in vascular parameters between POAG and PXG could not be ensured yet using the various devices (RTVue-XR SD-OCT, Cirrus HD-OCT, DRI OCT Triton; Topcon) [12][13][14][15][16][17][18][19]. So far, there has been a tendency for PXG to show a reduction in perfusion density,…”

Section: Introductionmentioning

confidence: 99%

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Macular, papillary and peripapillary perfusion densities measured with optical coherence tomography angiography in primary open angle glaucoma and pseudoexfoliation glaucoma

Cornelius

Pilger

Riechardt

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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Purpose To compare the blood flow situation in primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG) using optical coherence tomography angiography (OCTA). Methods In this prospective study a total of 26 POAG and 23 PXG eyes were included. All patients underwent a complete ophthalmological examination including standard automated perimetry, stereoscopic photographs of the optic disc, peripapillary retinal nerve fibre layer analysis and examination of vascular parameters of the optic nerve head (ONH), the peripapillary region and macula using OCTA. In addition to the vascular parameters recorded by the device, the vascular images were graphically evaluated using Image J. All recorded vascular parameters were compared between both groups and correlated to structural and functional parameters. Results The mean superficial perifoveal plexus perfusion density (PD) was significantly lower in PXG eyes than compared to POAG eyes using OCTA (32.57% ± 3.57% vs. 34.92% ± 2.11%, p = 0.007). The mean PD parameters for the superficial peripapillary plexus (40.98% ± 3.04% vs. 42.09% ± 2.29%, p = 0.152) as well as the size of the foveal avascular zone (FAZ) (0.23 mm2 ± 0.1 mm2 vs. 0.23 mm2 ± 0.09 mm2) did not differ between both groups. Additional graphic evaluation using Image J showed no significant difference for superficial perifoveal plexus PD (32.97% ± 1.11% vs. 33.35% ± 0.95%, p = 0.194) and peripapillary plexus PD (46.65% ± 0.83% vs. 46.95% ± 0.5%, p = 0.127) between the groups. Retinal nerve fibre layer (RNFL) thickness correlated significantly with peripapillary plexus PD for both OCTA data and Image J data (p < 0.001, p = 0.032). Conclusion The severity of the glaucoma seems to be crucial for peripapillary and macular perfusion densities, and not the form of glaucoma. An additional graphic evaluation is a possible step that could be implemented to improve the comparability of OCTA scans and to optimize the possibility of quantitative perfusion analysis in the case of deviating quality criteria.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Macular, papillary and peripapillary perfusion densities measured with optical coherence tomography angiography in primary open angle glaucoma and pseudoexfoliation glaucoma

Cornelius

Pilger

Riechardt

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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Optic nerve head microvascular characteristics in patients with unilateral pseudoexfoliation syndrome: an optical coherence tomography angiography study

et al. 2022

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The Role of Vessel Density as Measured by Optical Coherence Tomography Angiography in the Evaluation of Pseudoexfoliative Glaucoma: A Review of the Literature

et al. 2022

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Introduction:To review the existing literature about the optical coherence tomography angiography (OCTA) findings regarding peripapillary and macular vessel density (VD) in patients with pseudoexfoliative glaucoma (PXG). Methods: A comprehensive search of the PubMed database was conducted to include articles up to November 1, 2021, using an appropriate search algorithm. The retrieved articles were assessed for eligibility and filtered manually to exclude duplicates, while articles and book chapters cited in the reference lists of the eligible articles obtained by this method were reviewed so as not to miss any relevant studies. Results: There is consistency among the studies published so far that a significant decrease in peripapillary VD exists in eyes with PXG compared to controls, and macular VD has also been reported to be significantly lower in PXG eyes than controls. However, the existing literature remains controversial regarding OCTA findings in eyes with PXG compared to those with primary open-angle glaucoma (POAG). Several studies have found that peripapillary VD and macular VD were significantly lower in PXG than POAG, while other studies reported no significant difference. Conclusions: Eyes with PXG were found to present decreased peripapillary and macular VD compared to control eyes, suggesting that a vascular component, including optic nerve hypoperfusion, may be implicated in the pathogenesis of PXG.

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Comparison of vessel density in macular and peripapillary regions between primary open-angle glaucoma and pseudoexfoliation glaucoma using OCTA

Cited by 12 publications

References 25 publications

Macular, papillary and peripapillary perfusion densities measured with optical coherence tomography angiography in primary open angle glaucoma and pseudoexfoliation glaucoma

Macular, papillary and peripapillary perfusion densities measured with optical coherence tomography angiography in primary open angle glaucoma and pseudoexfoliation glaucoma

Optic nerve head microvascular characteristics in patients with unilateral pseudoexfoliation syndrome: an optical coherence tomography angiography study

The Role of Vessel Density as Measured by Optical Coherence Tomography Angiography in the Evaluation of Pseudoexfoliative Glaucoma: A Review of the Literature

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