Comparison of verbal memory impairment rates in mild cognitive impairment

Tremont, Geoffrey; Miele, Andrea S.; Smith, Megan M.; Westervelt, Holly James

doi:10.1080/13803390903401328

Cited by 32 publications

(31 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Second, only half of the Logical Memory test was administered to ADNI participants (Story A), potentially diminishing its reliability. Third, there is evidence that measures of story memory may be less sensitive to incipient dementia relative to verbal list learning tasks [24,25], suggesting that a list learning test may be a better screening measure. Fourth, general cognitive function was assessed only with the MMSE, a crude measure with limited ability to differentiate healthy controls versus MCI, or MCI versus AD [26].…”

Section: Discussionmentioning

confidence: 99%

Susceptibility of the conventional criteria for mild cognitive impairment to false‐positive diagnostic errors

Edmonds

Delano‐Wood

Clark

et al. 2014

Alzheimer's & Dementia

213

312

View full text Add to dashboard Cite

Background We assessed whether MCI subtypes could be empirically derived within the Alzheimer’s Disease Neuroimaging Initiative (ADNI) MCI cohort and examined associated biomarkers and clinical outcomes. Methods Cluster analysis was performed on neuropsychological data from 825 MCI ADNI participants. Results Four subtypes emerged: 1) Dysnomic (n=153), 2) Dysexecutive (n=102), 3) Amnestic (n=288), and 4) Cluster-Derived Normal (n=282) who performed within normal limits on cognitive testing. The Cluster-Derived Normal group had significantly fewer APOE-ε4 carriers and fewer who progressed to dementia compared to the other subtypes; they also evidenced cerebrospinal fluid AD biomarker profiles that did not differ from the normative reference group. Conclusions Identification of empirically-derived MCI subtypes demonstrates heterogeneity in MCI cognitive profiles that is not captured by conventional criteria. The large Cluster-Derived Normal group suggests that conventional diagnostic criteria are susceptible to false positive errors, with the result that prior MCI studies may be diluting important biomarker relationships.

show abstract

Section: Discussionmentioning

confidence: 99%

Susceptibility of the conventional criteria for mild cognitive impairment to false‐positive diagnostic errors

Edmonds

Delano‐Wood

Clark

et al. 2014

Alzheimer's & Dementia

213

312

View full text Add to dashboard Cite

show abstract

“…Foremost, the two measures may assess different aspects of learning and memory. Compared to story learning, serial list-learning has been shown to be more sensitive to episodic memory changes in MCI [57,58] and more sensitive to detection of early AD pathology [59]. Second, we used a correction factor, which may be so strict that it creates a Type II error.…”

Section: Discussionmentioning

confidence: 99%

Subjective Memory Complaint Only Relates to Verbal Episodic Memory Performance in Mild Cognitive Impairment

Gifford

Liu

Damon

et al. 2015

JAD

View full text Add to dashboard Cite

Background A cognitive concern from the patient, informant, or clinician is required for the diagnosis of mild cognitive impairment (MCI); however, the cognitive and neuroanatomical correlates of complaint are poorly understood. Objective We assessed how self-complaint relates to cognitive and neuroimaging measures in older adults with MCI. Method MCI participants were drawn from the Alzheimer’s Disease Neuroimaging Initiative and dichotomized into two groups based on the presence of self-reported memory complaint (no complaint n=191, 77±7 years; complaint n=206, 73±8 years). Cognitive outcomes included episodic memory, executive functioning, information processing speed, and language. Imaging outcomes included regional lobar volumes (frontal, parietal, temporal, cingulate) and specific medial temporal lobe structures (hippocampal volume, entorhinal cortex thickness, parahippocampal gyrus thickness). Results Linear regressions, adjusting for age, gender, race, education, Mini-Mental State Examination score, mood, and apolipoprotein E-4 status, found that cognitive complaint related to immediate (β=−1.07, p<0.001) and delayed episodic memory performances assessed on a serial list learning task (β=−1.06, p=0.001) but no other cognitive measures or neuroimaging markers. Conclusions Self-reported memory concern was unrelated to structural neuroimaging markers of atrophy and measures of information processing speed, executive functioning, or language. In contrast, subjective memory complaint related to objective verbal episodic learning performance. Future research is warranted to better understand the relation between cognitive complaint and surrogate markers of abnormal brain aging, including Alzheimer’s disease, across the cognitive aging spectrum.

show abstract

“…Several previous reports have described MCI-associated impairments in immediate recall (Greenaway et al, 2006; Moulin et al, 2004; Rabin et al, 2009; Ribeiro et al, 2007; Silva et al, 2012), delayed recall (20-30 minutes, (Belleville, Sylvain-Roy, de Boysson, & Menard, 2008; Della Sala, Cowan, Beschin, & Perini, 2005; Hudon et al, 2006; Rabin et al, 2009; Tremont, Miele, Smith, & Westervelt, 2010) and autobiographical longer term memory (Leyhe, Muller, Milian, Eschweiler, & Saur, 2009), but none have directly addressed consolidation. Consolidation is an active reorganization of the memory process, involving the strengthening of synaptic connections and the recruitment of additional brain areas which will later improve recall (Milner, 1989; Paller, 1997; Squire & Alvarez, 1995; Teyler & DiScenna, 1986; Wittenberg & Tsien, 2002).…”

Section: Discussionmentioning

confidence: 99%

Memory consolidation in aging and MCI after 1 week.

et al. 2014

View full text Add to dashboard Cite

Objective To assess consolidation in amnestic mild cognitive (aMCI) impairment, controlling for differences in initial learning and using a protracted delay period for recall. Methods Fifteen individuals with MCI were compared to fifteen healthy older adult controls on a story learning task. Subjects were trained to criteria to equalize initial learning across subjects. Recall was tested at both the 30-minute typically used delay and a 1-week delay used to target consolidation. Results Using repeated measures ANOVAs adjusted for age, we found group × time point interactions across the entire task between the final trial and 30-minute delay, and again between the 30-minute and 1-week delay periods, with MCI having greater declines in recall as compared to controls. Significant group main effects were also found, with MCI recalling less than controls. Conclusion Consolidation was impaired in aMCI as compared to controls. Our findings indicate that MCI-related performance typically measured at 30 minutes underestimates MCI-associated memory deficits. This is the first study to isolate consolidation by controlling for initial learning differences and using a protracted delay period to target consolidation in an MCI sample.

show abstract

Comparison of verbal memory impairment rates in mild cognitive impairment

Cited by 32 publications

References 21 publications

Susceptibility of the conventional criteria for mild cognitive impairment to false‐positive diagnostic errors

Susceptibility of the conventional criteria for mild cognitive impairment to false‐positive diagnostic errors

Subjective Memory Complaint Only Relates to Verbal Episodic Memory Performance in Mild Cognitive Impairment

Memory consolidation in aging and MCI after 1 week.

Contact Info

Product

Resources

About