Comparison of Ventricular Arrhythmia Frequency in Patients With Ischemic Cardiomyopathy Versus Nonischemic Cardiomyopathy Treated With Implantable Cardioverter Defibrillators

Ermis, Cengiz; Zhu, Alan X.; VanHeel, Laura; Lemke, Mary Jo; Sakaguchi, Scott; Lurie, Keith G.; Lü, Fei; Lin, Joseph; Benditt, David G.

doi:10.1016/j.amjcard.2005.03.051

Cited by 11 publications

(12 citation statements)

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“…At 33-month follow-up of 485 patients with ischemic cardiomyopathy and of 299 patients with nonischemic cardiomyopathy in the present study, the incidence of appropriate ICD shocks was 37% in patients with ischemic cardiomyopathy versus 31% in patients with nonischemic cardiomyopathy (p not significant). Unlike the other 2 studies [7, 8], there was no significant difference in baseline characteristics between patients with ischemic versus nonischemic cardiomyopathy in the present study. In other studies, appropriate ICD shocks occurred at 33-month follow-up in 329 of 1,038 patients (32%) [11], at 70-month follow-up in 421 of 1,382 patients (31%) [12], at 17-month follow-up in 169 of 719 patients (24%) in the Multicenter Automatic Defibrillator Implantation Trial II [13], at 29-month follow-up in 33 of 229 patients (14%) with nonischemic cardiomyopathy in the Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation Trial [14], and at 31-month follow-up in 52 of 140 patients (37%) with nonischemic cardiomyopathy [15].…”

Section: Discussioncontrasting

confidence: 92%

“…In the study by Ermis et al [7], there were 250 patients with ICDs. Mortality was 19% in patients with ischemic cardiomyopathy versus 11% in patients with nonischemic cardiomyopathy ( p value not stated).…”

Section: Discussionmentioning

confidence: 99%

“…Mortality was 19% in patients with ischemic cardiomyopathy versus 11% in patients with nonischemic cardiomyopathy ( p value not stated). The number of patients with nonischemic cardiomyopathy versus ischemic cardiomyopathy, the follow-up time for each group, and the baseline characteristics of each group for the 250 patients are not stated [7]. …”

Section: Discussionmentioning

confidence: 99%

“…At 30-month follow-up of 148 patients with ischemic heart disease and an ICD and of 60 patients with nonischemic heart disease and an ICD, ventricular tachycardia and ventricular fibrillation episodes per month were not significantly different between the 2 groups [7]. At 19-month follow-up of 105 patients with ischemic cardiomyopathy and of 48 patients with nonischemic cardiomyopathy and nonsustained ventricular tachycardia, appropriate ICD shocks occurred in 50% of patients with nonischemic cardiomyopathy versus 36% of patients with ischemic cardiomyopathy ( p not significant) [8].…”

Section: Introductionmentioning

confidence: 99%

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Incidence of appropriate cardioverter-defibrillator shocks and mortality in patients with implantable cardioverter-defibrillators with ischemic cardiomyopathy versus nonischemic cardiomyopathy at 33-month follow-up

Gandhi¹,

Aronow²,

Desai³

et al. 2010

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IntroductionThe aim of the study was to investigate at long-term follow-up the incidence of appropriate implantable cardioverter-defibrillator (ICD) shocks and of all-cause mortality in patients with ICDs with ischemic cardiomyopathy versus nonischemic cardiomyopathy.Material and methodsICDs were implanted in 485 patients with ischemic cardiomyopathy and in 299 patients with nonischemic cardiomyopathy, all of whom had coronary angiography. Baseline characteristics were not significantly different between the 2 groups. Follow-up was 965 days in patients with ischemic cardiomyopathy versus 1039 days in patients with nonischemic cardiomyopathy (p not significant). The ICDs were interrogated every 3 months to see if shocks occurred.ResultsAppropriate ICD shocks occurred in 179 of 485 patients (37%) with ischemic cardiomyopathy and in 93 of 299 patients (31%) with nonischemic cardiomyopathy (p not significant). All-cause mortality occurred in 162 of 485 patients (33%) with ischemic cardiomyopathy and in 70 of 299 patients (23%) with nonischemic cardiomyopathy (p = 0.002).ConclusionsThe incidence of appropriate ICD shocks was not significantly different at 33-month follow-up in patients with ischemic cardiomyopathy versus nonischemic cardiomyopathy. However, patients with ischemic cardiomyopathy had a significantly higher incidence of all-cause mortality than patients with nonischemic cardiomyopathy (p = 0.002).

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Section: Discussioncontrasting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Incidence of appropriate cardioverter-defibrillator shocks and mortality in patients with implantable cardioverter-defibrillators with ischemic cardiomyopathy versus nonischemic cardiomyopathy at 33-month follow-up

Gandhi¹,

Aronow²,

Desai³

et al. 2010

aoms

View full text Add to dashboard Cite

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“…The median follow-up in all 5 patients was 20 months (range [15][16][17][18][19][20][21][22][23][24] had VT with pre-syncope which was correctly diagnosed and treated by a discharge by the ICD.…”

Section: Follow Upmentioning

confidence: 99%

Expanding Applications of Defibrillators and Cardiac Resynchronization Therapy to Include Adult Congenital Heart Disease

Michael¹,

Mayosi²,

Morgan³

et al. 2011

Cardiac Defibrillation - Mechanisms, Challenges and Implications

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Follow-up of implantable cardioverter-defibrillator therapy: comparison of coronary artery disease and dilated cardiomyopathy

et al. 2014

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PurposeSince several large trials have proven the effectiveness of implantable cardioverter-defibrillators (ICDs) in patients with left ventricular dysfunction, disadvantages have become more apparent. As the prognosis of patients with cardiovascular diseases is improving, assessment of ICD patients and re-evaluation of the current guidelines is mandatory. We aimed to evaluate differences in mortality and occurrence of (in)appropriate shocks in ICD patients with coronary artery disease (CAD) or dilated cardiomyopathy (DCM).MethodsIn a large teaching hospital, all consecutive patients with systolic dysfunction due to CAD or DCM who received an ICD with and without resynchronisation therapy, were collected in a database.ResultsA total of 320 consecutive patients (age 67 ± 10 years) were classified as CAD patients and 178 (63 ± 11 years) as DCM patients. Median follow-up was 40 months (interquartile range [IQR] 23─57 months). All–cause mortality was 14 % (CAD 15 % vs DCM 13 %). Appropriate shocks occurred in 13 % of all patients (CAD 15 % vs DCM 11 %, p = 0.12) and inappropriate shocks occurred in 10 % (CAD 8 % vs DCM 12 %, p = 0.27). Multivariate analysis demonstrated impaired left ventricular ejection fraction, QRS >120, age ≥75 years and low estimated glomerular filtration rate as predictors for all-cause mortality. Predictors for inappropriate shocks were permanent and paroxysmal atrial fibrillation.ConclusionMortality rates were similar in patients with CAD and DCM who received an ICD. Furthermore, no differences were found in the occurrence of appropriate and inappropriate ICD interventions between these patient groups.

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Comparison of Ventricular Arrhythmia Frequency in Patients With Ischemic Cardiomyopathy Versus Nonischemic Cardiomyopathy Treated With Implantable Cardioverter Defibrillators

Cited by 11 publications

References 11 publications

Incidence of appropriate cardioverter-defibrillator shocks and mortality in patients with implantable cardioverter-defibrillators with ischemic cardiomyopathy versus nonischemic cardiomyopathy at 33-month follow-up

Incidence of appropriate cardioverter-defibrillator shocks and mortality in patients with implantable cardioverter-defibrillators with ischemic cardiomyopathy versus nonischemic cardiomyopathy at 33-month follow-up

Expanding Applications of Defibrillators and Cardiac Resynchronization Therapy to Include Adult Congenital Heart Disease

Follow-up of implantable cardioverter-defibrillator therapy: comparison of coronary artery disease and dilated cardiomyopathy

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