Comparison of vecuronium with ORG 9487 and their interaction

Abstract

Purpose: To compare the pharmacodynamic behaviour of vecuronium with that of ORG 9487, we measured the time-course of action of equipotent doses of ORG 9487 and vecuronium and investigated their mutual interaction when given in succession. Methods: Sixty ASA I-II patients were anaesthetized with thiopentone, fentanyl, halothane and nitrous oxide and assigned randomly to four groups. Each patient received an initial dose (ID) of either vecuronium (V) or ORG

Rapacuronium: clinical pharmacology

“…Rapid onset of block with rapacuronium has been confirmed in several subsequent studies using a variety of anaesthetic, nerve stimulation and recording techniques [7][8][9][10][11]. However, the onset time of rapacuronium 1.5 mg kg À1 is significantly faster than that of mivacurium 0.25 mg kg À1 , vecuronium 0.07 mg kg À1 and rocuronium 0.6 mg kg À1 (Table 1) [9,10,12]. However, the onset time of rapacuronium 1.5 mg kg À1 is significantly faster than that of mivacurium 0.25 mg kg À1 , vecuronium 0.07 mg kg À1 and rocuronium 0.6 mg kg À1 (Table 1) [9,10,12].…”

“…The clinical duration of rapacuronium 1.5 mg kg À1 is shorter than that of mivacurium 0.25 mg kg À1 and equipotent doses of vecuronium and rocuronium, although recovery to a train-of-four ratio of 0.7 is slightly longer for rapacuronium (Table 1) [9,10,12]. Repeated or continuous administration may lead to prolonged recovery after rapacuronium (see below).…”

“…This time was similar to the time for 90% recovery following succinylcholine 1.0 mg kg À1 . c Schiere et al [9]. Typical onset and recovery data for succinylcholine 1.0 mg kg -1 , rapacuronium 1.5 and 2.5 mg kg -1 , mivacurium 0.25 mg kg -1 and rocuronium 0.6 mg kg -1 (data are mean and SD) [12].…”

Clinical Pharmacology of Rapacuronium Bromide, a New Short‐Acting Neuromuscular Blocking Agent

“…Several studies evaluated the drug's onset of neuromuscular block in adults (Table 1). [7][8][9][16][17][18][19][20][21][22][23][24][25][26][27][28] Onset time, defined as the interval between administration and maximum depression of muscle twitch, after a dose of 1.5-2.0 mg/kg is similar to that of succinylcholine but significantly faster than those after intubating doses of vecuronium, mivacurium, atracurium, or rocuronium. 7, 18-21, 27, 29 Peak effect after a dose of 1.5 mg/kg occurs between 60 and 114 seconds, most commonly around 70-90 seconds.…”

“…7, 18-21, 27, 29 Peak effect after a dose of 1.5 mg/kg occurs between 60 and 114 seconds, most commonly around 70-90 seconds. 7,8,[18][19][20][21][22][23]27 Differences in reported mean times to peak effect probably are due to variations in anesthetic techniques, methods of measuring muscle function, and whether the dose was based on the active moiety or bromide salt. 24 A 1.5-mg/kg dose of rapacuronium is equivalent to 1.7 mg/kg of its bromide salt.…”