Comparison of Vasosol and University of Wisconsin Solutions on Early Kidney Function After 24 Hours of Cold Ischemia in a Canine Autotransplantation Model

Polyak, Maximilian M. R.; Grosche, Astrid

doi:10.1016/j.jss.2007.11.727

Cited by 12 publications

(8 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With this model of canine autologous kidney transplant, renal function decreased, confirmed by an elevation in serum creatinine values and comparable to previous results with this model (16,17). As expected, the accompanying decrease in renal plasma clearance of iodinated contrast medium could be detected by CT. Serum creatinine is an insensitive indirect measurement of renal function, increasing only when GFR is severely impaired (22).…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Patlak plot analysis CT‐GFR for the determination of renal function: comparison of normal dogs with autologous kidney transplant dogs

Alexander

Authier

Castillo

et al. 2010

Contrast Media & Molecular

View full text Add to dashboard Cite

Glomerular filtration rate (GFR) can be determined using Patlak plot analysis with single-slice dynamic computed tomography (CT). Acute autologous graft failure has several causes, all of which induce a measurable decrease in glomerular filtration rate. This study demonstrated in an experimental model of canine autologous renal transplant that CT-derived renal plasma clearance was significantly lower (p = 0.002) in dogs having undergone transplant (0.077 +/- 0.058 ml min(-1) ml renal tissue(-1)) compared with control dogs (0.396 +/- 0.139 ml min(-1) ml renal tissue(-1)). A significant negative curvilinear relationship was seen between serum creatinine and total renal plasma clearance (R(2) = 0.84, p = 0.0001). Alterations in renal time attenuation curve shape in dogs having undergone transplant may have been related to increased renal vascular resistance related to tubular necrosis. CT-GFR may be a useful experimental tool in the evaluation of renal dysfunction in transplant models.

show abstract

Section: Discussionsupporting

confidence: 89%

“…Autologous renal transplant models are used to test non-immunologic conditions, such as kidney preservation conditions, that may modify graft function delay during the acute phase following transplantation (16)(17)(18). Acute autologous graft failure can be caused by surgical problems (e.g.…”

Section: Introductionmentioning

confidence: 99%

Patlak plot analysis CT‐GFR for the determination of renal function: comparison of normal dogs with autologous kidney transplant dogs

Alexander

Authier

Castillo

et al. 2010

Contrast Media & Molecular

View full text Add to dashboard Cite

show abstract

Section: How To Flush the Donated Kidney?mentioning

confidence: 99%

“…Flushing the donated kidney is another complex discussion in medical studies (Lin et al, 2004;Lee et al, 2006;Polyak et al, 2008;LEE & MANGINO, 2009). In veterinary literature, there is only one study showing that a novel organ perfusion solution improved early kidney graft function and cellular integrity after ischemia/reperfusion (POLYAK et al, 2008) compared with saline (0.9% NaCl) solution, that has been used routinely in veterinary renal transplants to flush the renal artery (MATHEWS et al, 2000). Other discoveries using Vasosol (VAS) and University of Wisconsin (UW) solutions have attenuated ischemia-reperfusion damage and had the best post-operative results (POLYAK et al, 2008), followed by ascorbic acid (Lee et al, 2006), 5-aminoimidazole-4-carboxamide-1-β-D-ribonucleoside, (AICAR) and N-acetyl cysteine (NAC) (LIN et al, 2004).…”

Section: How To Flush the Donated Kidney?mentioning

confidence: 99%

Future strategies to improve short- and long-term outcomes of renal transplantation in dogs

et al. 2021

View full text Add to dashboard Cite

Transplants for cats with naturally occurring renal disease have been introduced into clinical practice, but canine renal transplantation represents a greater challenge because of the lack of a balanced immunosuppressive protocol, difficulty in selecting compatible canine kidney donors, and absence of transplantation monitoring protocols. This and other important factors will be discussed in this review to help improve short- and long-term outcomes for renal transplantation in dogs.

show abstract

“…Further studies by Polyak et al [ 105 ] concerned the effectiveness of Vasosol compared to the UW solution. The dog kidney autotransplantation model was used.…”

Section: Hormones With a Potential Nephroprotective Effectmentioning

confidence: 99%

The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature

Ostróżka-Cieślik

Dolińska

2020

Molecules

View full text Add to dashboard Cite

Transplantation is currently a routine method for treating end-stage organ failure. In recent years, there has been some progress in the development of an optimal composition of organ preservation solutions, improving the vital functions of the organ and allowing to extend its storage period until implantation into the recipient. Optimizations are mostly based on commercial solutions, routinely used to store grafts intended for transplantation. The paper reviews hormones with a potential nephroprotective effect, which were used to modify the composition of renal perfusion and preservation solutions. Their effectiveness as ingredients of preservation solutions was analysed based on a literature review. Hormones and trophic factors are innovative preservation solution supplements. They have a pleiotropic effect and affect normal renal function. The expression of receptors for melatonin, prolactin, thyrotropin, corticotropin, prostaglandin E1 and trophic factors was confirmed in the kidneys, which suggests that they are a promising therapeutic target for renal IR (ischemia-reperfusion) injury. They can have anti-inflammatory, antioxidant and anti-apoptotic effects, limiting IR injury.

show abstract

Comparison of Vasosol and University of Wisconsin Solutions on Early Kidney Function After 24 Hours of Cold Ischemia in a Canine Autotransplantation Model

Cited by 12 publications

References 28 publications

Patlak plot analysis CT‐GFR for the determination of renal function: comparison of normal dogs with autologous kidney transplant dogs

Patlak plot analysis CT‐GFR for the determination of renal function: comparison of normal dogs with autologous kidney transplant dogs

Future strategies to improve short- and long-term outcomes of renal transplantation in dogs

The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature

Contact Info

Product

Resources

About