Comparison of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in SCID mice

Lee, Kuen Yong; Peters, Martin C.; Mooney, David J.

doi:10.1016/s0168-3659(02)00349-8

Cited by 160 publications

(93 citation statements)

References 35 publications

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“…Volpert et al demonstrated that IL-4 is a potent inhibitor of angiogenesis in vivo when introduced locally as well as when injected systemically [21]. Lee et al, however, reported that IL-4 significantly enhanced the tube formation in the absence of VEGF or bFGF [32]. This finding suggests that IL-4 has angiogenic activity under certain conditions.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms of interleukin-4, -10 and 12B genes and diabetic retinopathy

et al. 2011

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In diabetic retinopathy (DR) and other angiogenesis-associated diseases, increased levels of cytokines, inflammatory cells, and angiogenic factors are present. We investigated the hypothesis that rs2243250 polymorphism of the interleukin 4 (IL-4) gene or rs1800896 polymorphism of the interleukin 10 (IL-10) gene, and rs3212227 polymorphism of the 3’ untranslated region (3’ UTR) of the interleukin-12 p40 gene (IL12B) may be associated with the development of proliferative diabetic retinopathy (PDR) in Caucasians with type 2 diabetes (DM2). This cross sectional case — control study included 189 patients with PDR and 187 patients with type 2 diabetes without PDR. Polymorphisms rs1800896 of the IL-10 gene, rs2243250 of the IL-4 gene, and rs3212227 of IL12B gene were analyzed by ARMS -PCR and RFLP -PCR methods. Multivariate analysis demonstrated the GG genotype of the rs1800896 polymorphism of the IL-10 gene to be associated with increased risk for PDR (OR=1.99; 95% CI=1.11–3.57; P=0.02), whereas the TT genotype of the rs2243250 polymorphism of the IL-4 gene and the AA genotype of the rs3212227 polymorphism of the IL-12 gene were not independent risk factors for PDR. Our findings suggest that the genetic variations at the IL-10 promoter gene might be a genetic risk factor for PDR in Caucasians with type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Polymorphisms of interleukin-4, -10 and 12B genes and diabetic retinopathy

et al. 2011

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“…[101][102][103] Moreover, the antiangiogenic effects of IL-4 can be mediated indirectly through its effects on tumor stromal fibroblasts. 104 In addition to these effects on stromal cells, direct anti-tumor functions of IL-4 on tumor cells have also been reported, such as as T cells, produce IL-4, which contributes to the transition of normal macrophages to tumor-promoting TAMs in part by inducing cathepsin activity that facilitates tumor growth, angiogenesis and invasion.…”

Section: Il-4 Induces Cysteine Cathepsin Activity In Tamsmentioning

confidence: 99%

Alternative activation of tumor-associated macrophages by IL-4

2010

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“…When anti-IL-4 mAb was added, new blood vessels formed again (25). In vitro, IL-4 inhibited the migration of cultured bovine and human microvascular cells and suppressed the formation of tube-like structure by human umbilical vein endothelial cells (HUVEC) induced by vascular endothelial growth factor (VEGF) and bFGF (26). Moreover, Saleh et al observed that IL-4-induced inhibition of C6 rat glioma was accompanied by reduced levels of vascularization (27,28).…”

Section: The Mechanism Of Exogenous Il-4-induced Tumor Rejectionmentioning

confidence: 99%