Comparison of various doses of carbon 13-labeled aminopyrine for a carbon 13-labeled aminopyrine demethylation blood test in healthy dogs

Moeller, Erik M.; Steiner, Jörg M.; Williams, David A.; Tetrick, Mark A.; Burr, John

doi:10.2460/ajvr.67.7.1110

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…Consistent with findings of previous studies, [17][18][19][20] no clinically obvious adverse effects developed in any of the dogs during the study and the following 7 days. Despite the apparent safety of the 13 C-ADBT in the 75 dogs used in all studies [17][18][19][20] to date, no long-term hematologic or serum biochemical analyses have been performed as part of a more rigorous safety evaluation. Mild organ damage may be more important in dogs with compromised hepatic function.…”

Section: Discussionsupporting

confidence: 91%

“…This test involves IV administration of 13 C-aminopyrine and assessment of the PCD; it has been analytically validated and shown to be technically feasible. [17][18][19] In preliminary experiments in dogs, 20 the results of the 13 C-ADBT were similar to those obtained by use of the breath aminopyrine demethylation test in humans; there appeared to be an inverse correlation of PCD with increasing severity of hepatic disease (as determined histologically). However, the true usefulness of the 13 C-ADBT in dogs has yet to be defined.…”

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confidence: 57%

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Optimization of sample handling and processing for the carbon 13-labeled aminopyrine demethylation blood test and determination of a reference range for test results in healthy dogs

DeBiasio

Steiner²,

Suchodolski³

et al. 2008

ajvr

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Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 57%

Optimization of sample handling and processing for the carbon 13-labeled aminopyrine demethylation blood test and determination of a reference range for test results in healthy dogs

DeBiasio

Steiner²,

Suchodolski³

et al. 2008

ajvr

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Assessment of liver function in dogs using the 13C-galactose breath test

Silva

Wyse

Goodfellow

et al. 2010

The Veterinary Journal

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The utility of uric acid assay in dogs as an indicator of functional hepatic mass

Hill

Leisewitz

Goddard

2011

J. S. Afr. Vet. Assoc.

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Uric acid was used as a test for liver disease before the advent of enzymology. Three old studies criticised uric acid as a test of liver function. Uric acid, as an end-product of purine metabolism in the liver, deserved re-evaluation as a liver function test. Serumtotal bile acids are widely accepted as the most reliable liver function test. This study compared the ability of serumuric acid concentration to assess liver function with that of serumpre-prandial bile acids in dogs. In addition, due to the renal excretion of uric acid the 2 assays were also compared in a renal disease group. Using a control group of healthy dogs, a group of dogs with congenital vascular liver disease, a group of dogs with non-vascular parenchymal liver diseases and a renal disease group, the ability of uric acid and pre-prandial bile acids was compared to detect reduced functional hepatic mass overall and in the vascular or parenchymal liver disease groups separately. Sensitivities, specificities and predictive value parameters were calculated for each test. The medians of uric acid concentration did not differ significantly between any of the groups, whereas pre-prandial bile acids medians were significantly higher in the liver disease groups compared with the normal and renal disease group of dogs. The sensitivity of uric acid in detecting liver disease overall was 65% while the specificity of uric acid in detecting liver disease overall was 59 %. The sensitivity and specificity of uric acid in detecting congenital vascular liver disease was 68%and 59 %, respectively. The sensitivity and specificity of uric acid in detecting parenchymal liver disease was 63%and 60 %, respectively. The overall positive and negative predictive values for uric acid in detecting liver disease were poor and the data in this study indicated uric acid to be an unreliable test of liver function. In dogs suffering from renal compromise serum uric acid concentrations may increase into the abnormal range due to its renal route of excretion

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Comparison of various doses of carbon 13-labeled aminopyrine for a carbon 13-labeled aminopyrine demethylation blood test in healthy dogs

Abstract: The PCD is superior to CUMPCD for the quantification of aminopyrine demethylation. Administration of (13)C-(13)C-aminopyrine at a dose of 2 mg/kg is appropriate for use in the (13)C-aminopyrine demethylation blood test in healthy dogs.

Cited by 3 publications

References 13 publications

Optimization of sample handling and processing for the carbon 13-labeled aminopyrine demethylation blood test and determination of a reference range for test results in healthy dogs

Optimization of sample handling and processing for the carbon 13-labeled aminopyrine demethylation blood test and determination of a reference range for test results in healthy dogs

Assessment of liver function in dogs using the 13C-galactose breath test

The utility of uric acid assay in dogs as an indicator of functional hepatic mass

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