Comparison of Value Set Based on DCE and/or TTO Data: Scoring for EQ-5D-5L Health States in Japan

Shiroiwa, Takeru; Ikeda, Shunya; Noto, Shinichi; Igarashi, Ataru; Fukuda, Takashi; Saito, Shinya; Shimozuma, Kojiro

doi:10.1016/j.jval.2016.03.1834

Cited by 190 publications

(160 citation statements)

References 27 publications

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“…Here, we applied the new EQ-5D-5L value sets from eight countries [16][17][18][19][20][21][22][23]: England, the Netherlands, Spain, Canada, Uruguay, China, Japan, and Korea. For ease of exposition, the English value set would be emphasised, though results for other countries' value sets were discussed.…”

Section: Measures Of Variablesmentioning

confidence: 99%

“…A key limitation of this previous study is that it was based on an interim value set, which was a 'cross walk' between the earlier three-level 2 EQ-5D (EQ-5D-3L) and the EQ-5D-5L descriptive system [15]. Most recently, several country-specific EQ-5D-5L value sets have been published, including four Western countries (England, the Netherlands, Spain, Canada), three Asian countries (China, Japan, Korea) and one South American (Uruguay) [16][17][18][19][20][21][22][23]. Hence, the existing mapping algorithm for D-39 is becoming obsolete following the publication of these new EQ-5D-5L value sets.…”

Section: Introductionmentioning

confidence: 99%

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Do country-specific preference weights matter in the choice of mapping algorithms? The case of mapping the Diabetes-39 onto eight country-specific EQ-5D-5L value sets

et al. 2018

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Purpose: To develop mapping algorithms that transform Diabetes-39 (D-39) scores onto EQ-5D-5L utility values for each of eight recently published country-specific EQ-5D-5L value sets, and to compare mapping functions across the EQ-5D-5L value sets.Methods: Data include 924 individuals with self-reported diabetes from six countries. The D-39 dimensions, age and gender were used as potential predictors for EQ-5D-5L utilities, which were scored using value sets from eight countries (England, Netherland, Spain, Canada, Uruguay, China, Japan and Korea). Ordinary least squares, generalized linear model, beta binomial regression, fractional regression, MM-estimation, and censored least absolute deviation were used to estimate the mapping algorithms. The optimal algorithm for each country-specific value set was primarily selected based normalized root mean square error (NRMSE), normalized mean absolute error (NMAE) and adjusted-r 2 . Cross-validation with 5-fold approach was conducted to test the generalizability of each model. Results:The fractional regression model with loglog as a link function consistently performed best in all country-specific value sets. For instance, the NRMSE (0.1282) and NMAE (0.0914) were the lowest, while adjusted-r 2 was the highest (52.5%) when the English value set was considered. Among D-39 dimensions, the energy and mobility was the only one that was consistently significant for all models. Conclusions:The D-39 can be mapped onto the EQ-5D-5L utilities with good predictive accuracy. The fractional regression model, which is appropriate for handling bounded outcomes, outperformed other candidate methods in all country-specific value sets. However, the regression coefficients differed reflecting preference heterogeneity across countries.

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Section: Measures Of Variablesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Do country-specific preference weights matter in the choice of mapping algorithms? The case of mapping the Diabetes-39 onto eight country-specific EQ-5D-5L value sets

et al. 2018

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“…The EuroQol 5 Dimension 5 Level (EQ-5D-5L) questionnaire was developed by the EuroQol group to investigate healthrelated QOL in adults [13]. The Japanese version of the EQ-5D-5L was developed by Shiroiwa et al [14] to evaluate QOL reflecting Japanese values. The EQ-5D-5L is widely used in clinical studies and health status surveys targeting the general population and uses a comprehensive scale based on preferences to assess cardinal changes in health status [15,16].…”

Section: Assessment Of Qolmentioning

confidence: 99%

“…The EQ-5D-5L is widely used in clinical studies and health status surveys targeting the general population and uses a comprehensive scale based on preferences to assess cardinal changes in health status [15,16]. While the values in the Japanese version [14] differ from those in the original, the utility values of QOL in this study were calculated using the Japanese version of the EQ-5D-5L to reflect the values of the Japanese people. We used a hybrid model prepared by mapping discrete choice experiment (DCE) data onto composite time trade-off (cTTO) data [14] to determine the EQ-5D-5L utility value.…”

Section: Assessment Of Qolmentioning

confidence: 99%

Real-world data of the association between quality of life using the EuroQol 5 Dimension 5 Level utility value and adverse events for outpatient cancer chemotherapy

Hirose

Fujii

Iihara

et al. 2020

Support Care Cancer

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Background Outpatient cancer chemotherapy may lead to improved quality of life (QOL) by allowing treatment to continue without impairing the social lives of patients compared with hospitalization. However, the occurrence of serious adverse events may cause a decline in QOL. We investigated the relationship between outpatient chemotherapy-induced adverse events and QOL. Methods A single-center retrospective descriptive study was conducted in patients who received outpatient chemotherapy at Gifu University Hospital (Gifu, Japan) between September 2017 and December 2018. The utility values of QOL, type and severity of adverse events, type of cancer, chemotherapy regimen, and other patient demographics were analyzed. Adverse events were graded according to the Common Terminology Criteria for Adverse Events, version 4.0. QOL was evaluated using the Japanese version of the EuroQol 5 Dimension 5 Level (EQ-5D-5L). Associations between the EQ-5D-5L utility value and serious adverse events were assessed using adjusted (age and sex) odds ratios obtained with a proportional odds logistic regression model. Results Data from 1008 patients who received 4695 chemotherapy cycles were analyzed. According to proportional odds logistic regression, the adverse events that significantly correlated with a decreased EQ-5D-5L utility value were malaise, edema of the limbs, peripheral neuropathy, pruritus, and dry skin. Based on the proportional odds logistic analysis, neither cancer type nor anticancer drugs were significantly correlated with the EQ-5D-5L utility value in patients who received chemotherapy. Pharmaceutical care for peripheral neuropathy significantly improved patients' EQ-5D-5L utility value from 0.747 to 0.776 (P < 0.01). Conclusions Adverse events (i.e., peripheral neuropathy, malaise, and edema of the limbs) are significantly correlated with a decrease in QOL, regardless of the type of cancer or anticancer drugs used. Pharmaceutical care provided by pharmacists in collaboration with physicians may improve QOL.

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“…The EQ-5D-5L index score was calculated based on a scoring algorithm representing the preferences of Japanese residents because there is no population-based preference weight available in Taiwan. 16 Statistical analysis A logistic regression analysis was carried out on the APD versus CAPD patients using the variables listed in online supplementary table S2. We then used the propensity score analysis to match the APD patients with the CAPD Figure 1 Study sample selection process.…”

Section: Outcome Measurementmentioning

confidence: 99%

Economic costs of automated and continuous ambulatory peritoneal dialysis in Taiwan: a combined survey and retrospective cohort analysis

Tang

Huang

et al. 2017

BMJ Open

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ObjectivesTaiwan succeeded in raising the proportion of peritoneal dialysis (PD) usage after the National Health Insurance (NHI) payment scheme introduced financial incentives in 2005. This study aims to compare the economic costs between automated PD (APD) and continuous ambulatory PD (CAPD) modalities from a societal perspective.Design and settingA retrospective cohort of patients receiving PD from the NHI Research Database was identified during 2004–2011. The 1:1 propensity score matched 1749 APD patients and 1749 CAPD patients who were analysed on their NHI-financed medical costs and utilisation. A multicentre study by face-to-face interviews on 117 APD and 129 CAPD patients from five hospitals located in four regions of Taiwan was further carried out to collect data on their out-of-pocket payments, productivity losses and quality of life with EuroQol-5D-5L.Outcome measuresThe NHI-financed medical costs, out-of-pocket payments and productivity losses of APD and CAPD patients.ResultsThe total NHI-financed medical costs per patient-year after 5 years of follow-up were significantly higher with APD than CAPD (US$23 005 vs US$19 237; p<0.01). In terms of dialysis-related costs, APD had higher costs resulting from the use of APD machines (US$795) and APD sets (US$2913). Significantly lower productivity losses were found with APD (US$2619) than CAPD (US$6443), but the out-of-pocket payments were not significantly different. The differences in NHI-financed medical costs and productivity losses between APD and CAPD remained robust in the bootstrap analysis. The total economic costs of APD (US$30 401) were similar to those of CAPD (US$29 939), even after bootstrap analysis (APD, US$28 399; CAPD, US$27 960). No discernable differences were found in the results of mortality and quality of life between the APD and CAPD patients.ConclusionsAPD had higher annual dialysis-related costs and lower annual productivity losses than CAPD, which made the economic costs of APD very close to those of CAPD in Taiwan.

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Comparison of Value Set Based on DCE and/or TTO Data: Scoring for EQ-5D-5L Health States in Japan

Abstract: Japanese value sets based on DCE were demonstrated. On comparing the observed cTTO scores, we found that the hybrid model was slightly superior to the simpler methods, including the TTO model.

Cited by 190 publications

References 27 publications

Do country-specific preference weights matter in the choice of mapping algorithms? The case of mapping the Diabetes-39 onto eight country-specific EQ-5D-5L value sets

Do country-specific preference weights matter in the choice of mapping algorithms? The case of mapping the Diabetes-39 onto eight country-specific EQ-5D-5L value sets

Real-world data of the association between quality of life using the EuroQol 5 Dimension 5 Level utility value and adverse events for outpatient cancer chemotherapy

Economic costs of automated and continuous ambulatory peritoneal dialysis in Taiwan: a combined survey and retrospective cohort analysis

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