Comparison of vaginal ointment of honey and clotrimazole for treatment of vulvovaginal candidiasis: A random clinical trial

Banaeian, Sh.; Sereshti, M; Mahmoud, Rafieian; Farahbod, Farinaz; Kheiri, Soleiman

doi:10.1016/j.mycmed.2017.07.003

Cited by 23 publications

(18 citation statements)

References 15 publications

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“…Honey is considered to be a functional food and currently has gained much attention because of its positive biological and health properties. Numerous randomised controlled clinical studies have provided compelling evidence that honey possesses antibacterial/antibiofilm, antiviral and anti‐inflammatory properties when applied topically. One of the important and the most studied effects of honey is its antibacterial activity.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial potential of Swiss honeys and characterisation of their bee‐derived bioactive compounds

et al. 2019

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BACKGROUND: Antibacterial activity of honey is not only crucial characteristic in selection of honey for medical usage but also an important honey quality marker. The aim of the study was to characterise the antibacterial potential of 29 honey samples representing the main types of multi-floral blossom and honeydew honeys produced in Switzerland. Antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa was expressed as a minimum inhibitory and bactericidal concentrations (MIC and MBC). Furthermore, the content of bee-derived glucose oxidase (GOX) and its enzymatic product, H 2 O 2 , were also evaluated.RESULTS: All honey samples successfully met basic defined criteria (moisture and hydroxymethylfurfural (HMF)) tested in this study. Honeydew honeys were the most effective honey samples and generated the highest levels of H 2 O 2 . A strong significant correlation was found between the overall antibacterial activity and the level of H 2 O 2 among all honey samples. Interestingly, the content of GOX in honey samples did not correlate with their antibacterial activity as well as H 2 O 2 production capacity. A weak antibacterial activity was determined in five floral honeys, most likely due to increased enzymatic activity of pollen-derived catalase.CONCLUSION: This study showed that antibacterial effect of Swiss honey samples is associated mainly with H 2 O 2 .

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Section: Introductionmentioning

confidence: 99%

Antibacterial potential of Swiss honeys and characterisation of their bee‐derived bioactive compounds

et al. 2019

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“…In another study, triazoles such as fluconazole and terconazole as well as imidazoles such as clotrimazole, miconazole, itraconazole, ketoconazole and agents such as nystatin have been recommended for the treatment of candidal vaginitis [ 22 ]. In a study by Banaeian et al , the effect of clotrimazole and honey gel was studied in two groups of women with vaginitis [ 23 ]. The authors reported that vaginal inflammation and secretion showed significant improvement in the clotrimazole group, and no complications were seen in either group.…”

Section: Discussionmentioning

confidence: 99%

Chlorhexidine, clotrimazole, metronidazole and combination therapy in the treatment of vaginal infections

et al. 2021

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This was a clinical trial study that aimed to investigate the efficacy of vaginal chlorhexidine gel in the treatment of vulvovaginal candidiasis, bacterial vaginosis, and nonspecific vaginitis. The study population included patients who complained of vaginal discharge and presented to our University Gynecology Clinic. The data were analyzed using the Statistical Package for the Social Sciences (SPSS) software. The student t-test and Mann-Whitney U test were used to analyze the quantitative and ordinal data, respectively. In order to analyze the qualitative data, the Chi-square or Fischer’s exact tests were used. The mean satisfaction score in the vulvovaginal candidiasis patients who received chlorhexiine vaginal gel was 9.06 and 8.29 in the patients who received clotrimazole vaginal cream. The Mann-Whitney test did not show a statistically significant difference between mean scores of VAS in these two groups with vulvovaginal candidiasis (P=0.027). Among the patients with bacterial vaginosis, the mean satisfaction score was 8.91 in the chlorhexidine vaginal gel group and 8.72 in the metronidazole tablet group (P=0.607). In the nonspecific vaginitis group, the mean satisfaction score was 8.83 in the chlorhexidine vaginal gel group and 9.17 in the combination group (metronidazole + clotrimazole vaginal cream)(P=0.401). The highest mean visual analog scale score (VAS) score was documented in the combination therapy group. We found that chlorhexidine vaginal gel is a more effective method for the treatment and improvement of vaginal infections. The benefits of chlorhexidine gel have a positive therapeutic effect as a single drug in nonspecific vaginitis, rather than simultaneous administration of two agents.

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“…Eighty women diagnosed with vulvovaginal candidiasis were treated seven days with either honey ointment or clotrimazole ointment. The symptoms including inflammation, vaginal discharge, and irritation at baseline in the fourth and eighth days of the treatment were examined and compared between the two groups (Banaeian et al, 2017). In both groups, all the symptoms disappeared after the treatment.…”

Section: Discussionmentioning

confidence: 99%

Bioapygin Herbal Ointment and Pessaries Compared to Acidosalus Pessaries and Vaginal Probiotic in the Treatment of Vulvo-Vaginal Disorders

Oreščanin

Guštek²

2019

Current Perspectives on Medicinal and Aromatic Plants (CUPMAP)

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Objective / Purpose: The objective of the study was assessment of the clinical efficacy and safety of Bioapigyn ® vaginal ointment and pessaries compared to Acidosalus ® pessaries and vaginal probiotic in alleviating vulvo-vaginal disorders. Materials and methods: 124 females were randomly selected into four groups (each of 31 participants) and treated once a day for ten days with: A) Bioapigyn ® vaginal pessaries (one pessary per day); B) 2.5 mL of Bioapigyn ® vaginal ointment; C) Acidosalus ® vaginal pessaries (one pessary per day); D) 2.5 mL of Acidosalus ® vaginal probiotic. All the patients were subjected to gynecological examination, measurement of vaginal pH, Pap test, native and KOH test, self-assessment and clinical assessment of the symptoms at baseline and following the therapy. Results: Following the treatment with Bioapigyn ® vaginal ointment, Bioapigyn ® pessaries, Acidosalus ® pessaries, Acidosalus ® vaginal probiotic the total score of vulvo-vaginal disorders decreased for 85.2%, 88.9%, 82.7% and 78%, respectively and vaginal pH decreased between 9.1% and 14.3%. Native test showed normalization of the vaginal flora following the treatment with all four products with no significant difference among the products. Conclusion/Discussion: Both Bioapigyn ® and Acidosalus ® products were highly efficient in alleviation of vulvo-vaginal disorders. The products created unfavorable conditions for pathogenic growth through the lowering of vaginal pH value, promoting the growth of lactobacilli, creating the environment with low water activity and creating a protective layer on the damaged mucosa that creates a physical barrier to the entrance of the pathogens into the cells and enables the recovery of the vaginal mucosa.

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Comparison of vaginal ointment of honey and clotrimazole for treatment of vulvovaginal candidiasis: A random clinical trial

Cited by 23 publications

References 15 publications

Antibacterial potential of Swiss honeys and characterisation of their bee‐derived bioactive compounds

Antibacterial potential of Swiss honeys and characterisation of their bee‐derived bioactive compounds

Chlorhexidine, clotrimazole, metronidazole and combination therapy in the treatment of vaginal infections

Bioapygin Herbal Ointment and Pessaries Compared to Acidosalus Pessaries and Vaginal Probiotic in the Treatment of Vulvo-Vaginal Disorders

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