Comparison of urodynamic results and quality of life between women with interstitial cystitis and overactive bladder

Overactive bladder syndrome in nulliparous women

“…9 In terms of UDS parameters in the current Fang et al's study 9 and based on the order of data presented in NP, NSD, and C/S groups, mean peak flow was 18.9, 21.4, 20.7 mL/s; mean flow was 7.5, 9.4, and 9.0 mL/s; mean MUCP was 104.9, 77.9, and 86.4 cm H 2 O; mean FUL was 31.0 24.5, and 27.1 mm; and mean maximum cystometric capacity (MCC) was 339, 345, and 325 mL, respectively. 9 Compared with previous OAB Taiwanese women reported by Dr. Hsu et al, 11 who has shown below that mean peak flow was 17.9 mL/s; mean MUCP was 73.4 cm H 2 O; mean FUL was 26.5 mm; and mean MCC was 333 mL, 11 the certain degree of difference may exist, if statistical analysis was performed. However, both data were significantly lower than that obtained from the healthy women (23.5 mL/s for mean peak flow and 13 mL/s for mean flow as an example).…”

“…However, both data were significantly lower than that obtained from the healthy women (23.5 mL/s for mean peak flow and 13 mL/s for mean flow as an example). 12 In fact, Dr. Hsu et al 11 further separated their OAB patients into the absence and presence of DO, and found the statistically significant difference of certain-type UDS parameters between two groups, including residual urine and peak flow rate. 11 Even though Dr. Hsu et al 11 tried their effort to distinguish OAB from interstitial cystitis, 11 since the latter should be managed by different strategies, such as an intravesical hyaluronic acid therapy, 13,14 the statistically significant difference was dramatically varied greatly when OAB women if these women were further separated into the absence of presence of DO.…”

The T-type calcium channel CaV3.2 regulates bladder afferent responses to mechanical stimuli

“…28 Although OAB affects approximately 10% of both men and women, IC/BPS disproportionately affects women, with a female-to-male ratio of around 5:1. 18,36,41,43,70,72 Transduction of bladder stretch into sensation relies on the detection of mechanical distortion by mechanosensitive ion channels in urothelial cells and bladder afferent nerve terminals, 4,82,83 and the subsequent amplification of this signal to depolarise bladder-innervating afferent nerves. Mounting evidence implies a key role for Ca V 3.2 in the regulation/amplification of mechanosensory signals to modulate peripheral sensory signals that are relayed to the CNS.…”

“… 28 Although OAB affects approximately 10% of both men and women, IC/BPS disproportionately affects women, with a female-to-male ratio of around 5:1. 18 , 36 , 41 , 43 , 70 , 72 …”

“…Bladder hypersensitivity disorders, including OAB and IC/BPS, cause chronic and debilitating illness that severely reduces quality of life for both men and women. 41 , 70 , 72 Unravelling the complex neurobiology that regulates bladder afferent mechanosensitivity will be key to the development of effective treatments for bladder hypersensitivity in OAB and IC/BPS. 28 Our data suggests that Ca V 3.2 inhibition is an attractive therapeutic approach for relieving bladder hypersensitivity.…”