Comparison of UPLC-MS/MS and HPLC-UV methods for the determination of zaltoprofen in human plasma

Jang, Ji-Hun; Jeong, Seung‐Hyun; Cho, Hea-Young; Lee, Yong-Bok

doi:10.1007/s40005-018-00416-w

Cited by 10 publications

(9 citation statements)

References 8 publications

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“…The C max values were 1500 ± 308 and 1504 ± 233 ng/mL for the reference and test formulations, respectively. The T max results indicate that both formulations reached the highest DAP blood concentration within 1 h, consistent with previously reported values [ 22 , 23 ]. Bioequivalence was further evaluated by statistically comparing the relative AUC ratio and 90% confidence intervals (CI) for logarithmic-transformed data.…”

Section: Resultssupporting

confidence: 91%

Improved Manufacturability and In Vivo Comparative Pharmacokinetics of Dapagliflozin Cocrystals in Beagle Dogs and Human Volunteers

et al. 2021

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Dapagliflozin (DAP), which improves glycemic control in patients with type 2 diabetes mellitus, has poor physical properties against heat and moisture, thus hindering its manufacturing potential. The superior physicochemical properties of a recently developed cocrystal of DAP and citric acid (DAP cocrystal) in comparison with those of DAP and Forxiga®, a patented solvate form with propandiol monohydrate, were identified via structural analysis and moisture sorption isotherm. For the first time, the formulation, manufacturability, and in vivo bioavailability of DAP cocrystals were successfully investigated to develop oral dosage forms that substitute Forxiga®. The intrinsic dissolution rate of DAP cocrystal was controlled by varying particle size distribution. Unlike the direct compression (DC), roller compaction (RC) was more preferable to obtain good flowability of dry granules for a continuous manufacturing system. The cocrystal structure was maintained throughout the stability assessment period. In Vitro dissolution pattern differences of the optimized DAP cocrystal tablet with RC and the reference tablet, Forxiga® 10 mg, were pharmaceutically equivalent within 5% in four different media. Furthermore, comparative pharmacokinetic analysis confirmed that a 10 mg DAP cocrystal tablet with RC was bioequivalent to a 10 mg Forxiga® tablet, as assessed in beagle dogs and human volunteers.

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Section: Resultssupporting

confidence: 91%

Improved Manufacturability and In Vivo Comparative Pharmacokinetics of Dapagliflozin Cocrystals in Beagle Dogs and Human Volunteers

et al. 2021

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“…The between-run accuracy ranged from 92.0% to 104% with the precision ranging from 0.9% to 14.6%. These validation results were within the acceptable range, indicating the accuracy and reproducibility of the established method [ 24 , 27 ].…”

Section: Resultsmentioning

confidence: 82%

“…The parameters related to the ion source were as follows: collision gas pressure, 1.5 mTorr; sheath gas pressure, 30 Arb; capillary temperature, 300 °C; vaporizer temperature, 300 °C; and auxiliary valve flow rate, 10 Arb. The method was validated according to the FDA guidelines [ 23 ], with regard to the accuracy, precision, selectivity, sensitivity, and linearity [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

Investigation of the Factors Responsible for the Poor Oral Bioavailability of Acacetin in Rats: Physicochemical and Biopharmaceutical Aspects

et al. 2021

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Acacetin, an important ingredient of acacia honey and a component of several medicinal plants, exhibits therapeutic effects such as antioxidative, anticancer, anti-inflammatory, and anti-plasmodial activities. However, to date, studies reporting a systematic investigation of the in vivo fate of orally administered acacetin are limited. Moreover, the in vitro physicochemical and biopharmaceutical properties of acacetin in the gastrointestinal (GI) tract and their pharmacokinetic impacts remain unclear. Therefore, in this study, we aimed to systematically investigate the oral absorption and disposition of acacetin using relevant rat models. Acacetin exhibited poor solubility (≤119 ng/mL) and relatively low stability (27.5–62.0% remaining after 24 h) in pH 7 phosphate buffer and simulated GI fluids. A major portion (97.1%) of the initially injected acacetin dose remained unabsorbed in the jejunal segments, and the oral bioavailability of acacetin was very low at 2.34%. The systemic metabolism of acacetin occurred ubiquitously in various tissues (particularly in the liver, where it occurred most extensively), resulting in very high total plasma clearance of 199 ± 36 mL/min/kg. Collectively, the poor oral bioavailability of acacetin could be attributed mainly to its poor solubility and low GI luminal stability.

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“…The calibration ranges for zaltoprofen in HPLC-UV and UPLC-MS/MS were 0.05-20 and 0.005-10 µg/mL, respectively. The developed methods satisfied the international guidance criteria and can be successfully applied to pharmacokinetic study of an 80 mg zaltoprofen tablet after oral administration to humans [32].…”

Section: Uplc Methodsmentioning

confidence: 91%

Reported estimation techniques for quantification of zaltoprofen: A review

Thangabalan¹,

Nagaraja²,

Petapalli³

et al. 2022

World J. Bio. Pharm. Health Sci.

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Zaltoprofen is a nonsteroidal anti-inflammatory drug used as an analgesic, antipyretic, and antinflammatory agent. It is a selective COX-2 inhibitor and also inhibits bradykinin-induced pain responses without blocking bradykinin receptors. Zaltoprofen is prescribed for treating pain and inflammatory conditions caused by various disorders such as dental pain, musculoskeletal pain, postoperative pain, and lumbar pain, and frozen shoulder, osteoarthritis and cervico branchial syndrome. There are various analytical methods for estimation of drug. This paper list out the various analytical methods for the drug.

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Comparison of UPLC-MS/MS and HPLC-UV methods for the determination of zaltoprofen in human plasma

Cited by 10 publications

References 8 publications

Improved Manufacturability and In Vivo Comparative Pharmacokinetics of Dapagliflozin Cocrystals in Beagle Dogs and Human Volunteers

Improved Manufacturability and In Vivo Comparative Pharmacokinetics of Dapagliflozin Cocrystals in Beagle Dogs and Human Volunteers

Investigation of the Factors Responsible for the Poor Oral Bioavailability of Acacetin in Rats: Physicochemical and Biopharmaceutical Aspects

Reported estimation techniques for quantification of zaltoprofen: A review

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