Comparison of Umbilical Cord Serum Vitamin D Levels between Infants with Transient Tachypnea of the Newborn and those without Respiratory Distress

Boskabadi, Hassan; Maamouri, Gholamali; Kalani-Moghaddam, Farnaz; Nakhaei, Mohammad Hosein Ataee; Zakerihamidi, Maryam; Rakhshanizadeh, Forough

doi:10.34172/aim.2020.55

Cited by 10 publications

(3 citation statements)

References 29 publications

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“…The occurrence rates of RDS are presented by reference to the severity of vitamin D deficiency. Thus, we used the various levels in meta-analysis: a vitamin D level below 30 ng/ml in two studies [ 5 , 27 ], 20 ng/ml in six studies [ 11 , 15 , 25 , 27 , 29 , 30 ], 15 ng/ml in two studies [ 16 , 23 ], and 10 ng/ml in nine studies [ 11 , 17 , 22 , 24 , 25 , 28 – 30 , 32 ].…”

Section: Resultsmentioning

confidence: 99%

Association between vitamin D level and respiratory distress syndrome: A systematic review and meta-analysis

et al. 2023

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Background Growing evidence suggests an association between the vitamin D levels and respiratory outcomes of preterm infants. The objective of this systematic review and meta-analysis was to explore whether premature neonates with a vitamin D deficiency have an increased risk of respiratory distress syndrome (RDS). Methods We searched PubMed, EMBASE, and the Cochrane Library up through July 20, 2021. The search terms were ‘premature infant’, ‘vitamin D’, and ‘respiratory distress syndrome’. We retrieved randomized controlled trials and cohort and case-control studies. For statistical analysis, we employed the random-effects model in Comprehensive Meta-Analysis Software ver. 3.3. We employed the Newcastle-Ottawa Scales for quality assessment of the included studies. Results A total of 121 potentially relevant studies were found, of which 15 (12 cohort studies and 3 case-control studies) met the inclusion criteria; the studies included 2,051 preterm infants. We found significant associations between RDS development in such infants and vitamin D deficiency within 24 h of birth based on various criteria, thus vitamin D levels < 30 ng/mL (OR 3.478; 95% CI 1.817–6.659; p < 0.001), < 20 ng/mL (OR 4.549; 95% CI 3.007–6.881; p < 0.001), < 15 ng/mL (OR 17.267; 95% CI 1.084–275.112; p = 0.044), and < 10 ng/ml (OR 1.732; 95% CI 1.031–2.910; p = 0.038), and an even lower level of vitamin D (SMD = –0.656; 95% CI –1.029 to –0.283; p = 0.001). Conclusion Although the vitamin D deficiency definitions varied and different methods were used to measure vitamin D levels, vitamin D deficiency or lower levels of vitamin D within 24 h of birth were always associated with RDS development. Monitoring of neonatal vitamin D levels or the maintenance of adequate levels may reduce the risk of RDS.

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Section: Resultsmentioning

confidence: 99%

Association between vitamin D level and respiratory distress syndrome: A systematic review and meta-analysis

et al. 2023

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“…The results of our study also show the effect of vitamin D in reducing lung damage and in ammatory processes. Numerous studies have suggested vitamin de ciency as a risk factor for respiratory problems in preterm infants, including RDSs and TTNs (4,12). Successful transition from fetal to neonatal life at delivery requires a series of extensive physiological changes in the cardiorespiratory system, leading to a change in the gas exchange pathway from the placenta to the lungs.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Maternal Vitamin D Intake on the Incidence of Nonspecific Respiratory Distress in Infants: A Randomized Clinical Trial

Boskabadi

Nakhaei

Pourbadakhshan

et al. 2022

Preprint

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Background vitamin D deficiency is associated with respiratory problems in neonates. The late preterm or near-term neonates who have been admitted for tachypnea and fully recovered before 12 h, we called Non-specific respiratory distress syndrome (NRDS). The present study aimed to evaluate the effect of 25(OH) D administration in pregnant women at risk of preterm delivery on the incidence of NRDS in their infants. Methods This single-blind clinical trial was performed on mothers and neonates with a gestational age of 32-37 weeks who were referred with labor pains from February 20th 2021 to June29th 2021 in the obstetrics and gynecology department and intensive treatment unit of Ghaem Hospital, Mashhad University of Medical Sciences, Iran. Within 72 h of preterm delivery, a single dose of 50,000 units of intramuscular 25-hydroxy vitamin D was injected into pregnant women in the intervention group. Also a sample containing 1.5 ml of whole blood was taken from the umbilical cord of the infant and mother to assess the level of vitamin D. Results In the present study, there was a significant relationship between the two groups of control and intervention in terms of weight (P=001), first (P=0.027) and fifth minute Apgar score (P=0.001) in infant, incidence of NRDS (P=0.001) and maternal age (P=0.004). The results showed no statistically significant difference between the two groups in terms of gender (p = 0.673), type of delivery (p = 0.299), level of vitamin D of the mothers (P=0.053) and infants (P=0.805). Conclusions The single injection of vitamin D into the mother prone to preterm birth over 31 weeks of gestation reduces transient respiratory problems in these infants. Trial registration: IRCT20110807007244N7 (19/02/2021)

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“…Serum levels of vitamin D below 30 ng/mL were considered as vitamin D deficiency. To describe the severity of vitamin D deficiency, we used the terms mild, moderate, and severe deficiency for vitamin D serum levels of 20 -30, 10 -20, and below 10 ng/dL, respectively (24). Finally, serum levels of vitamin D and the correlation between the levels of vitamin D in mothers and their newborns were measured.…”

Section: Methodsmentioning

confidence: 99%

Correlation of Vitamin D Serum Level of Mothers and Their Newborns

Boskabadi

Heidari

2021

Mod Care J

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Background: The possibility of vitamin D deficiency is high among mothers and their premature newborns. Objectives: Due to the high rate of vitamin D deficiency in Iranian women, this study aimed to determine the association between the serum levels of vitamin D in the blood of premature newborns and their mothers in the Iranian population. Methods: This cross-sectional study was conducted on 324 mothers and their 324 newborns with gestational age less than 37 weeks, who were referred to Ghaem Hospital affiliated to Mashhad University of Medical Sciences, Mashhad, Iran, during 2016-2020. After clamping, 1.5 cc blood samples were obtained through the umbilical cord to determine the neonates’ vitamin D levels. Finally, the serum levels of vitamin D were measured, and the correlation between the levels of vitamin D of mothers and their newborns was calculated. Results: The mean vitamin D levels of newborns and mothers were 15.75 ± 11.18 and 20.16 ± 13.41 ng/mL, respectively. Moreover, there was a high correlation between the vitamin D levels of mothers and their newborns (r = 0.672; P < 0.001). Furthermore, a significant correlation was observed between the vitamin D levels of mothers, who used vitamin D supplementation during pregnancy and their neonates’ levels (r = 0.773; P < 0.001). Conclusions: The findings suggest a positive correlation between neonatal and maternal vitamin D levels. Moreover, it seems that maternal vitamin D levels can predict neonatal vitamin D deficiency.

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Comparison of Umbilical Cord Serum Vitamin D Levels between Infants with Transient Tachypnea of the Newborn and those without Respiratory Distress

Cited by 10 publications

References 29 publications

Association between vitamin D level and respiratory distress syndrome: A systematic review and meta-analysis

Association between vitamin D level and respiratory distress syndrome: A systematic review and meta-analysis

The Effect of Maternal Vitamin D Intake on the Incidence of Nonspecific Respiratory Distress in Infants: A Randomized Clinical Trial

Correlation of Vitamin D Serum Level of Mothers and Their Newborns

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