Comparison of Types 1 and 2 Herpesvirus hominis Infection of Rabbit Eyes

Oh, Jang O.

doi:10.1001/archopht.1973.01000050473015

Cited by 20 publications

(5 citation statements)

References 15 publications

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“…In primary cultures of chicken embryo cells, HSV-2 produces plaques, whereas HSV-1 produces minute plaques or, more often, none at all (13). In rabbit eyes, HSV-2 strains produce severe keratitis that affects an entire layer of the cornea, whereas HSV-1 strains produce only superficial lesions that affect the epithelium and the upper third of the corneal stroma (24,29).…”

Section: Resultsmentioning

confidence: 99%

Different susceptibilities of skin to type 1 and type 2 herpes simplex viruses in newborn rabbits

Oh¹,

Minasi²

1980

Infect Immun

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Skin infections with type 1 herpes simplex virus (HSV-1) were compared with skin infections with type 2 virus (HSV-2). Five strains each of HSV-1 and HSV-2 were tested by injecting 103 50% tissue culture infective doses of each strain subcutaneously into 1-day-old New Zealand white rabbits. All five strains of HSV-2 produced severe skin lesions that resulted in wide dissemination of the infection to many organs, paralysis of the hind legs, and finally death. The virus could be isolated frequently from skin lesions, from various organs (liver, lungs, adrenal glands, brain, and eyes), and from circulating leukocytes and plasma. In contrast, all five strains of HSV-1 failed to produce significant skin lesions or dissemination of virus, only half of the skin lesions yielded HSV, and no virus could be isolated from the blood. These results indicate that HSV-1 does not grow well in the skin of newborn rabbits and fails to disseminate, whereas HSV-2 is dermatotropic and disseminates readily to many organs by hematogenous routes. Ever since Batignani (2) reported the first case of neonatal infection with herpes simplex virus (HSV) in 1934, neonatal HSV infection has been recognized with increasing frequency. Over 90% of isolates recovered from infections of newborns (usually derived from infected mothers) are type 2 HSV (HSV-2) (16). When neonates acquire herpes infection from the maternal genital tract, either in utero after its ascent from the cervix or during the course of delivery, the skin, eye, and ororespiratory ori

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Section: Resultsmentioning

confidence: 99%

Different susceptibilities of skin to type 1 and type 2 herpes simplex viruses in newborn rabbits

Oh¹,

Minasi²

1980

Infect Immun

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“…Nonimmunological factors such as the integrity of the skin and mucus membranes are important in preventing in fection. Nonspecific resistance factors, such as macrophages, natural killer cells and in terferons, play important roles in the early phases of primary infections, at a time when specific immune responses, such as humoral antibody and cell-mediated immunity, are still inactive [27][28][29][30][31][32].…”

Section: Interactions Between Host and Virusmentioning

confidence: 99%

Differential Virulence of Herpes simplex Virus Intratypic Strains

Heard¹,

Kasbarian

Smith³

1987

Dermatology

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Many events determine the severity, duration, and predisposition to recurrent herpes simplex virus (HSV) disease. In addition to the various host immune responses, such as local, humoral, and cellular immunity, which influence the outcome of infection and subsequent development of disease, evidence is also accumulating to suggest that intratypic strains of HSV may also play an important role in the outcome, depending on the degree of virulence each strain exhibits. Since it has been suggested that each individual is initially infected and colonized with a strain of virus whose characteristic virulence or avirulence will determine the type of HSV disease that individual will experience, it is suggested that intratypic strains should be considered an important variable in recurrent HSV disease.

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“…The lesions produced by HSV, type 2, are raised from the corneal surface in contrast to the flat HSV type 1 lesions (Hollenberg et aI., 1976;Hudson et ai., 1976;Oh and Stevens, 1973).…”

Section: Metaherpetic Keratitismentioning

confidence: 99%

Superficial Keratitis

1981

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Comparison of Types 1 and 2 Herpesvirus hominis Infection of Rabbit Eyes

Cited by 20 publications

References 15 publications

Different susceptibilities of skin to type 1 and type 2 herpes simplex viruses in newborn rabbits

Different susceptibilities of skin to type 1 and type 2 herpes simplex viruses in newborn rabbits

Differential Virulence of Herpes simplex Virus Intratypic Strains

Superficial Keratitis

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