Comparison of two twin-screw extruders for continuous granulation

Djurić, Dejan; Melkebeke, Barbara Van; Kleinebudde, Peter; Remon, Jean Paul; Vervaet, Chris

doi:10.1016/j.ejpb.2008.06.033

Cited by 70 publications

(29 citation statements)

References 14 publications

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“…NIR An overview of the runs containing an amount of anhydrous theophylline is given in Table 3. Runs (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) which were thought to contain anhydrous theophylline when investigated with Raman are all confirmed by NIR.…”

Section: Nir Spectroscopymentioning

confidence: 77%

“…As wet granulation is a commonly used unit operation within the pharmaceutical industry to improve compactibility and/or flowability of powder mixtures prior to tabletting, several continuous wet granulation techniques were developed which have been reviewed by Vervaet and Remon [14,15] Their co-workers [16][17][18][19] developed a continuous twin-screw granulator, which is now implemented in the commercially available ConsiGma™-system (GEA Pharma Systems nv., Collette™, Wommelgem, Belgium). Systems producing 25, 50 and 100 kg of granules per hour are commercially available.…”

Section: Gewijzigde Veldcodementioning

confidence: 99%

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Real-time assessment of critical quality attributes of a continuous granulation process

Fonteyne

Vercruysse

Díaz

et al. 2011

Pharmaceutical Development and Technology

102

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There exists the intention to shift pharmaceutical manufacturing of solid dosage forms from traditional batch production towards continuous production. The currently applied conventional quality control systems, based on sampling and time-consuming off-line analyses in analytical laboratories, would annul the advantages of continuous processing. It is clear that real-time quality assessment and control is indispensable for continuous production. This manuscript evaluates strengths and weaknesses of several complementary Process Analytical Technology (PAT) tools implemented in a continuous wet granulation process, which is part of a fully continuous from powder-to-tablet production line. The use of Raman and NIR spectroscopy and a particle size distribution analyzer is evaluated for the real-time monitoring of critical parameters during the continuous wet agglomeration of an anhydrous theophylline -lactose blend. The solid state characteristics and particle size of the granules were analyzed in real-time and the critical process parameters influencing these granule characteristics were identified. The temperature of the granulator barrel, the amount of granulation liquid added and, to a lesser extent, the powder feed rate were the parameters influencing the solid state of the active pharmaceutical ingredient (API). A higher barrel temperature and a higher powder feed rate, resulted in larger granules.

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Section: Nir Spectroscopymentioning

confidence: 77%

Section: Gewijzigde Veldcodementioning

confidence: 99%

Real-time assessment of critical quality attributes of a continuous granulation process

Fonteyne

Vercruysse

Díaz

et al. 2011

Pharmaceutical Development and Technology

102

View full text Add to dashboard Cite

show abstract

“…Some papers indicate the potential of extrusion as a continuous wet granulation technique [5]. Previous research works have been carried out on how some granule properties are affected by varying the powder feed rate, liquid content, screw speed [5][6][7] and screw configuration [8].…”

Section: Introductionmentioning

confidence: 99%

Twin screw wet granulation: Granule properties

Dhenge

Fyles

Cartwright

et al. 2010

Chemical Engineering Journal

138

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“…15 However, several studies on twin-screw granulation reported a broad granule size distribution, with the presence of fines and lumps. [5][6][7][8]11,16,17 A broad size distribution can have serious implications on the uniformity of granule drying as well as powder segregation during downstream processing; both of which are undesirable from an industrial perspective.…”

Section: Introductionmentioning

confidence: 99%

Granulation rate processes in the kneading elements of a twin screw granulator

Hagrasy

Litster

2013

AIChE Journal

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To characterize the granulation rate processes in the kneading section of the twin screw granulator, separate experiments were conducted using exclusively conveying elements as the baseline in addition to different configurations of kneading elements. The configuration parameters examined were the length of the kneading section, the advance angle, and the angle direction. Granule size, shape and liquid distribution were measured. Two main rate processes were observed (1) breakage and layering, and (2) Shear elongation and layering. Breakage was dominant in the 90 configuration while shear elongation dominated in the 30 reverse configurations, with other configurations giving some combination of the two rate processes. The distinct three-dimensional (3-D) shape characteristics of granules obtained from each configuration were crucial in elucidating the dominant granulation rate process in each case. The proposed granulation mechanisms explain the events leading to particular granule attributes, but more importantly provide insight into future optimization of twin screw granulation process.

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Comparison of two twin-screw extruders for continuous granulation

Cited by 70 publications

References 14 publications

Real-time assessment of critical quality attributes of a continuous granulation process

Real-time assessment of critical quality attributes of a continuous granulation process

Twin screw wet granulation: Granule properties

Granulation rate processes in the kneading elements of a twin screw granulator

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