Comparison of two RT-qPCR methods targeting BK polyomavirus microRNAs in kidney transplant recipients
Kenza Zoubir,
Véronique Descamps,
Aurélien Aubry
et al.
Abstract:BackgroundBK polyomavirus replication leads to progressive tubulointerstitial nephritis and ureteral stenosis, with a considerable risk of subsequent graft failure in kidney transplant recipients. Since specific antiviral therapies are lacking, new tools are required to enhance the biological monitoring of the infection. Viral microRNAs are promising new biomarkers, but the performance of RT-qPCR methods limits the clinical application and the validation of a standard method for quantification.MethodsWe compar… Show more
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