Comparison of Two New Controlled-Release Theophylline Formulations in the Management of Asthma in Children and Reliability of Salivary Theophylline Concentration

Al, Boner; Bennati, D; Miglioranzi, P; Gaburro, D

doi:10.3109/02770908609073157

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…However, the variability found in interindividual serudsaliva ratios and the wide scattering among the data points obtained with nonstimulated saliva actually precluded the clinical use of non-stimulated saliva measurements for the assessement of serum concentration of theophylline (Hendeles et al, 1977;Galant et ul, 1977;Danhof and Breimer, 1978;Boobis et ul, 1979;Jonkman et al, 1981;Kelly et ul, 1981;Munch et al 1981;Sharma et al, 1981;Boner et id, 1986;Iwasaki and Baba, 1987). This also holds true for teflon and paraffin stimulated saliva (Hendeles et a], 1977; Kelly et al, 1981; de Marino et al, 1986;Boner et al, 1985Boner et al, , 1986. Using citric-acid stimulated saliva, other authors claimed that this method minimized the scattering among the data points in asthmatic children treated with controlled release theophylline (Aviram et al, 1987).…”

Section: Introductionmentioning

confidence: 98%

Could saliva stand for plasma in theophylline monitoring in asthmatic children? Still a controversial problem

Gao

Pons

Rey

et al. 1992

Fundamemntal Clinical Pharma

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Theophylline determination in saliva was proposed several years ago as a convenient and non-invasive alternative to monitoring plasma in children and adults. Published data demonstrated that theophylline saliva concentration linearly correlates plasma concentration. However, the variability found in interindividual serum/saliva ratios and the wide scattering among the data points precluded the clinical use of saliva for theophylline monitoring. The purpose of this study was to compare different standardized methods for obtaining stimulated saliva intending to reduce the variability in plasma/saliva ratios and to determine the most reliable one. A group of 150 ambulatory chronic asthmatic 4.5 to 20.83 (10 +/- 3.7; M +/- SD) year-old patients receiving theophylline 6.85 +/- 1.88 mg/kg every 12 h as slow release preparations for 4 to 100 days was studied. One ml venous blood and salivary specimens were simultaneously collected 5.15 +/- 0.36 h after the morning maintenance dose. In a subgroup of 75 patients, saliva was collected using first a new device called salivette, immediately followed by the collection of an expectorated sample 30 s after citric acid crystals stimulation. In the other patients saliva was collected using citric acid containing salivette. Theophylline concentration was determined using HPLC. For all types of saliva collection, salivary and plasma theophylline concentrations correlated significantly. However whichever method was used, based on the -2 to +2 SD interval, a large range of plasma theophylline was predicted from a single salivary theophylline concentration. Despite a further standardization of the sampling of saliva, saliva theophylline could not accurately predict plasma concentration.

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Section: Introductionmentioning

confidence: 98%

Could saliva stand for plasma in theophylline monitoring in asthmatic children? Still a controversial problem

Gao

Pons

Rey

et al. 1992

Fundamemntal Clinical Pharma

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A prospective trial using salivary‐theophylline levels to guide asthma therapy

Virchow¹,

Mansfeld²,

Matthys³

et al. 1992

Pediatric Pulmonology

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In three prospectively designed studies, first saliva (SA) samples were collected simultaneously with serum (SE) from 86 children who received slow-release theophylline (Th) b.i.d. for treatment of bronchial asthma. SA was collected with a standardized sampling procedure. Regression analysis revealed a close correlation between SE and SA-Th levels (r = 0.959; SE = 1.87 x SA + 0.05) and yielded a "therapeutic SA-Th range" of 5.8 to 10.7 mg/L. In 16 children the diurnal variation was then assessed by measuring 6 SA-Th levels within 24 hr, using the same sampling method. At 0, 9, and 24 hr SE-Th levels were also measured. The levels of SE-Th and SA-Th were again closely correlated (0.914 less than or equal to r less than or equal to 0.949) and both remained constant over the 24-hr period. In the third prospective trial only SA levels were used to monitor Th therapy in 50 asthmatic children. Seven days after starting therapy SA-Th levels were measured and then the Th dose was increased weekly until SA-Th levels above 5.8 mg/L were reached. The following day SE and SA samples were collected simultaneously and their Th levels compared. In 36 of the 47 children who completed the study therapeutic SE-Th levels (greater than or equal to 10 and less than or equal to 20 mg/L) were measured; in one patient it was greater than or equal to 20 mg/L, in 6 it was between 8.0 and 10 mg/L, and only 4 had SE levels less than 8.0 mg/L.(ABSTRACT TRUNCATED AT 250 WORDS)

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Central nervous system stimulants and anorectic agents

Kelemen¹,

Knoll²

1987

Side Effects of Drugs Annual

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Comparison of Two New Controlled-Release Theophylline Formulations in the Management of Asthma in Children and Reliability of Salivary Theophylline Concentration

Cited by 4 publications

References 12 publications

Could saliva stand for plasma in theophylline monitoring in asthmatic children? Still a controversial problem

Could saliva stand for plasma in theophylline monitoring in asthmatic children? Still a controversial problem

A prospective trial using salivary‐theophylline levels to guide asthma therapy

Central nervous system stimulants and anorectic agents

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