Comparison of two methods for evaluating bone marrow metastasis of neuroblastoma: Reverse transcription‐polymerase chain reaction for tyrosine hydroxylase and magnetic resonance imaging

Takemoto, Chikayo; Nishiuchi, Ritsuo; Endo, Chie; Oda, Megumi; Seino, Yoshiki

doi:10.1111/j.1442-200x.2004.01921.x

Cited by 8 publications

(6 citation statements)

References 26 publications

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“…5 Several studies confirm a correlation between the identification of TH in BM and/or PBL and prognosis. Takemoto et al, 13 using RT-PCR confirmed an association between the molecular detection of TH in BM and PBL at diagnosis and poor prognosis. Fukuda et al 5 found that the persistence of positive TH mRNA by RT-PCR in BM within 4 months after the start of chemotherapy, predicts poor prognosis in advanced NB.…”

Section: Discussionmentioning

confidence: 78%

Minimal Residual Disease in Peripheral Blood Stem Cell Harvests From High-risk Neuroblastoma Patients

Avigad¹,

Feinberg-Gorenshtein

Luria

et al. 2009

Journal of Pediatric Hematology/Oncology

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Section: Discussionmentioning

confidence: 78%

Minimal Residual Disease in Peripheral Blood Stem Cell Harvests From High-risk Neuroblastoma Patients

Avigad¹,

Feinberg-Gorenshtein

Luria

et al. 2009

Journal of Pediatric Hematology/Oncology

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“…It is noninvasive and provides precise information for diagnosis, staging, and response to treatment [1][2][3][4][5]. The appearance of the bone marrow on MRI depends on the proportion and density of trabecular bone, fat, and water.…”

Section: Discussionmentioning

confidence: 99%

Case series of pediatric acute leukemia without a peripheral blood abnormality, detected by magnetic resonance imaging

et al. 2011

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Although abnormal peripheral blood counts are a key diagnostic finding for acute leukemia in children, between 2003 and 2010 we observed seven pediatric cases without peripheral blood abnormalities and showing abnormal signals in the bone marrow by magnetic resonance imaging (MRI). The common chief complaint in these patients was bone pain and fever. Bone marrow tests revealed six out of the seven cases to be acute leukemia, whereas one patient was diagnosed with juvenile idiopathic arthritis (JIA). There was no evident difference in MRI findings between leukemia patients and JIA patient. In three cases of leukemia, initial bone marrow aspiration failed to show the presence of leukemic cells, and diagnosis was only made by repeated bone marrow examination. Our findings indicate that in some cases MRI detects leukemia at an earlier phase than does bone marrow aspiration, suggesting that MRI is useful for the diagnosis of acute leukemia.

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“…Therefore in addition to bone marrow examination, newer sensitive methods for assessing marrow infiltration are now being used, including nuclear scans, reverse transcription-polymerase chain reaction (RT-PCR) for tyrosine hydroxylase and magnetic resonance imaging (MRI) for its detection [21]. However, bone marrow examination is a simple and cost effective method to stage and monitor cases in a setup with limited resources.…”

Section: Discussionmentioning

confidence: 99%

Bone Marrow Involvement in Neuroblastoma: A Study of Hemato-morphological Features

Rastogi

Naseem

Varma

et al. 2014

Indian J Hematol Blood Transfus

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Bone marrow involvement in neuroblastoma indicates advanced stage of disease. The recent use of autologous bone marrow ''rescue'', has provided an additional important reason for accurate assessment of bone marrow status in newly diagnosed patients. In this study, we analyzed 44 cases of neuroblastoma for bone marrow infiltration status and their hematological parameters. Eighty-eight bone marrow aspirate and trephine touch imprint smears and 44 trephine biopsy sections were examined in these 44 patients. Of these, 24 cases (54.5 %) showed marrow infiltration. Leucopenia and bicytopenia were significantly (p \ 0.05) associated with marrow infiltration. Both bone marrow aspirate and biopsy were positive for infiltration in 16 out of 24 positive cases. Only aspirate smears were positive in 4 and only trephine biopsy in another 4 cases. The pattern of infiltration consisted of rosette formation in 40.7 % cases on aspirate smears and 22.2 % cases in trephine biopsies. Remaining cases showed diffuse and interstitial presence of tumor cells and cases positive only on trephine biopsy, showed marked stromal reaction. Bilateral trephine biopsies combined with aspirate smears picked up all positive cases compared to when they were assessed alone.

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Comparison of two methods for evaluating bone marrow metastasis of neuroblastoma: Reverse transcription‐polymerase chain reaction for tyrosine hydroxylase and magnetic resonance imaging

Cited by 8 publications

References 26 publications

Minimal Residual Disease in Peripheral Blood Stem Cell Harvests From High-risk Neuroblastoma Patients

Minimal Residual Disease in Peripheral Blood Stem Cell Harvests From High-risk Neuroblastoma Patients

Case series of pediatric acute leukemia without a peripheral blood abnormality, detected by magnetic resonance imaging

Bone Marrow Involvement in Neuroblastoma: A Study of Hemato-morphological Features

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