Comparison of Two Interferon-γ Assays and Tuberculin Skin Test for Tracing Tuberculosis Contacts

Arend, Sandra M.; Thijsen, Steven; Leyten, Eliane M. S.; Bouwman, John; Franken, Willeke P. J.; B, Köster; Cobelens, Frank; Houte, Arend-Jan van; Bossink, Aik

doi:10.1164/rccm.200608-1099oc

Cited by 242 publications

(176 citation statements)

References 30 publications

Supporting

Mentioning

142

Contrasting

Unclassified

Order By: Relevance

“…However, the specificity of 52.4-57.9% was exceptionally low for a group with very low BCG vaccination coverage [8]. Cross-reactivity from previous exposure to nontuberculous mycobacteria could be a possible explanation [3], but differing abilities between T-Spot.TB and TST in detecting recent and remote infection might be an alternative explanation [21,22]. Overall, a very low discriminating power of the TST was predicted, with a positive likelihood ratio consistently ,2 and a negative likelihood ratio of ,0.33 (table 5).…”

Section: Discussionmentioning

confidence: 99%

“…The absence of a gold standard remains a major problem in the comparison of diagnostic tests for LTBI. Similar to other studies [7][8][9][10][11][21][22][23][24], no direct information was provided as to how well the new IFN-c release assay was able to predict subsequent risk of active TB disease. Indirect estimates of sensitivity and specificity through surrogate measures might not reflect actual test performance for the latent infection state.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of T-Spot.TB and tuberculin skin test among silicotic patients

Leung

Yam²,

Yew³

et al. 2008

European Respiratory Journal

View full text Add to dashboard Cite

In the present study, T-Spot.TB and the tuberculin skin test (TST) were compared in the screening of latent tuberculosis infection among silicotic patients.A conditional probability model was used to compare the potential clinical utilities of T-Spot.TB and TST performed on 134 silicotic subjects from December 1, 2004 to January 31, 2007. Data from a historical cohort were also reanalysed for further comparison.Agreement with T-Spot.TB was best using a TST cut-off of 10 mm. Age o65 yrs independently predicted a tuberculin reaction ,10 mm (odds ratio53), but not a negative T-Spot.TB response. Lower measures of agreement were observed among current smokers and those aged o65 yrs. Tuberculin reaction size was well correlated with both early secretary antigenic target 6 and culture filtrate protein 10 spot counts, except among current smokers. Within the current estimates of sensitivity (88-95%) and specificity (86-99%) for T-Spot.TB, the positive likelihood ratio for T-Spot.TB test would be substantially higher (6.29-95.0 versus 1.65-1.94) and negative likelihood ratio substantially lower (0.05-0.14 versus 0.32-0.41) than the corresponding ratios for the tuberculin test. A low tuberculosis risk differential was similarly observed between tuberculinnegative and untreated tuberculin-positive subjects in the historical cohort.T-Spot.TB is likely to perform better than tuberculin test in the screening of latent tuberculosis infection among silicotic subjects.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparison of T-Spot.TB and tuberculin skin test among silicotic patients

Leung

Yam²,

Yew³

et al. 2008

European Respiratory Journal

View full text Add to dashboard Cite

show abstract

“…As the tuberculin skin test has been an adequate, albeit nonspecific, tool for the detection of infected persons at risk of tuberculosis reactivation, and that low sensitivity has not been a problem in immunocompetent individuals, it is highly unlikely that those late tuberculin skin test converters would have an increased risk of progression to tuberculosis. During follow-up of the population screened after exposure at the supermarket [89], only one patient developed pulmonary tuberculosis. This patient initially had both positive tuberculin skin test and IGRA (both ELISPOT and ELISA) results (unpublished data).…”

Section: Sectionmentioning

confidence: 99%

“…In a number of contact investigations, substantially fewer BCG unvaccinated subjects had positive IGRA results compared with positive tuberculin skin test results [74,86,[89][90][91][92][93][94][95][96][97][98][99]. Comparability between the two IGRAs was generally good, whereas the agreement between tuberculin skin test and IGRA was poor, owing to false-positive tuberculin skin test results in BCG-vaccinated subjects or, based on studies among BCG unvaccinated subjects, to lower sensitivity of IGRA for detection of infections acquired in the past.…”

Section: Sectionmentioning

confidence: 99%

“…In contacts from an outbreak at a supermarket [89], conversion to positive tuberculin skin test results 1 yr after exposure has been demonstrated in a small subgroup of patients with an initially negative tuberculin skin test in association with a positive IGRA result [100]. As the tuberculin skin test has been an adequate, albeit nonspecific, tool for the detection of infected persons at risk of tuberculosis reactivation, and that low sensitivity has not been a problem in immunocompetent individuals, it is highly unlikely that those late tuberculin skin test converters would have an increased risk of progression to tuberculosis.…”

Section: Sectionmentioning

confidence: 99%

See 1 more Smart Citation

LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement

Mack

Migliori

Sester

et al. 2009

European Respiratory Journal

508

446

View full text Add to dashboard Cite

Tuberculosis control relies on the identification and preventive treatment of individuals who are latently infected with Mycobacterium tuberculosis. However, direct identification of latent tuberculosis infection is not possible. The diagnostic tests used to identify individuals latently infected with M. tuberculosis, the in vivo tuberculin skin test and the ex vivo interferon-c release assays (IGRAs), are designed to identify an adaptive immune response against, but not necessarily a latent infection with, M. tuberculosis. The proportion of individuals who truly remain infected with M. tuberculosis after tuberculin skin test or IGRA conversion is unknown. It is also uncertain how long adaptive immune responses towards mycobacterial antigens persist in the absence of live mycobacteria. Clinical management and public healthcare policies for preventive chemotherapy against tuberculosis could be improved, if we were to gain a better understanding on M. tuberculosis latency and reactivation. This statement by the TBNET summarises knowledge and limitations of the currently available tests used in adults and children for the diagnosis of latent tuberculosis infection.In summary, the main issue regarding testing is to restrict it to those who are known to be at higher risk of developing tuberculosis and who are willing to accept preventive chemotherapy.

show abstract

Prednisolone treatment affects the performance of the QuantiFERON gold in-tube test and the tuberculin skin test in patients with autoimmune disorders screened for latent tuberculosis infection

Belard

Semb

Rühwald

et al. 2011

Inflammatory Bowel Diseases

126

View full text Add to dashboard Cite

Oral prednisolone severely suppressed QFT-IT and TST performance, whereas the long-acting corticosteroids methotrexate, azathioprine, and 5-ASA did not have a similar detrimental effect. Patients should be screened for LTBI with QFT-IT or TST prior to initiation of prednisolone therapy and negative QFT-IT or TST results interpreted with caution in patients treated with any corticosteroid until further data are available.

show abstract

Comparison of Two Interferon-γ Assays and Tuberculin Skin Test for Tracing Tuberculosis Contacts

Cited by 242 publications

References 30 publications

Comparison of T-Spot.TB and tuberculin skin test among silicotic patients

Comparison of T-Spot.TB and tuberculin skin test among silicotic patients

LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement

Prednisolone treatment affects the performance of the QuantiFERON gold in-tube test and the tuberculin skin test in patients with autoimmune disorders screened for latent tuberculosis infection

Contact Info

Product

Resources

About