Comparison of two extraction methods for the determination of 135 pesticides in Corydalis Rhizoma, Chuanxiong Rhizoma and Angelicae Sinensis Radix by liquid chromatography-triple quadrupole-mass spectrometry. Application to the roots and rhizomes of Chinese herbal medicines

Liu, Jie; Tong, Ling; Li, Dongxiang; Meng, Wenting; Sun, Wanyang; Zhao, Yunli; Yu, Zhiguo

doi:10.1016/j.jchromb.2016.03.003

Cited by 31 publications

(20 citation statements)

References 29 publications

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“…Extraction techniques optimized in ginseng sample preparation have been developed based on a match between the target analyte solubility and solvent polarity, the ability of the solvent to limit extracting interfering coextractants, and sorbent selectivity for the target analyte and their effect on analyte recoveries. From a comparison of extraction techniques in the analyses of pesticides in ginseng (Table 1), the method most commonly used was a modification of QuEChERS (73% of studies) [21][22][23][24][25][26][27][28], followed by QuEChERS (27% of studies) [22,29,30], and supercritical fluid with CO 2 (9% of studies) [31]. Pesticides most commonly analyzed were OCPs (64% of studies), with organophosphates and carbamates also investigated.…”

Section: Review Of Existing Methods Utilized In Ginseng Analysesmentioning

confidence: 99%

A comparison of the effectiveness of QuEChERS, FaPEx and a modified QuEChERS method on the determination of organochlorine pesticides in ginseng

et al. 2021

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This study provides a review of methods used in the determination of organochlorine pesticides (OCPs) in ginseng and compares the effectiveness of three extraction methods (Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS), a modified QuEChERS and a Fast Pesticide Extraction (FaPEx)) in the analyses of 20 OCPs in ginseng root samples. For each method, sample mass, solvent volume and sorbent mass were varied to identify the optimum combination to effectively isolate analytes of interest from the complex sample matrix. Extracts were analyzed using the gas chromatography-μ-electron capture detector (GC-μ-ECD), and confirmatory analyses performed by gas chromatography-tandem-mass spectrometry (GC-MS/MS). Eighteen out of 20 OCPs spiked onto in-house prepared ginseng samples produced acceptable recoveries (51–156%) when extracted using QuEChERS and FaPEx. All 20 analytes, including dichlorodiphenyldichloroethane (p, p’- DDD) and dichlorodiphenyltrichloroethane (o, p’-DDT), produced acceptable recoveries (51–129%) with the use of a modified QuEChERS method. The applicability of the modified QuEChERS method was demonstrated through the analysis of ginseng samples grown in endosulfan-treated soil. The samples were analyzed by both GC-μ-ECD and GC-MS/MS with no significant difference identified in the results of each analytical method. This study highlights the applicability of the modified QuEChERS method, in combination with GC- μ-ECD, to determine organochlorine pesticides in ginseng. This may be especially useful for laboratories in developing countries and less advanced institutions without access to MS/MS instrumentation.

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Section: Review Of Existing Methods Utilized In Ginseng Analysesmentioning

confidence: 99%

A comparison of the effectiveness of QuEChERS, FaPEx and a modified QuEChERS method on the determination of organochlorine pesticides in ginseng

et al. 2021

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“…MeCN can precipitate proteins [41,42] and limit lipid solubility [26,27,43], Fig. 2, the highest recovery was obtained from the extractant containing 0.1% formic acid, which was conducive to the stability of pH-dependent pesticides [44,45]. Finally, water/MeCN (3:1, v/v) content with 0.1% formic acid was used as the optimum extractant.…”

Section: Sample Extractionmentioning

confidence: 96%

Simultaneous determination of 106 pesticides in nuts by LC–MS/MS using freeze‐out combined with dispersive solid‐phase extraction purification

Wang

Gong

Zhang

et al. 2017

J of Separation Science

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As a result of the low water content and high fat matrices in nuts, it is very difficult to simultaneously determine multi-pesticides in trace levels. Here, a sample pretreatment method was developed in which, microwave-assisted solvent extraction was firstly used to extract pesticides, and then a two-step cleanup method was conducted combining freeze-out with dispersive solid-phase extraction to remove the lipidic matrix. By this way, 106 pesticides were simultaneously determined in the complicated nut sample by using an ultra-high pressure liquid chromatography coupled with a tandem mass spectrometer. Average recoveries were 75.3-119.3% with relative standard deviations < 14% at three concentration levels. The limits of detection and quantification were in the ranges of 0.3-3.0 and 1.0-10.0 μg/kg, respectively. Furthermore, the method was successfully applied to the determination of pesticides in 180 commercial nut samples.

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“…dSPE is more effective in purifying the sample. Solvent extraction coupled with dSPE purification was a typical quick, easy, cheap, effective, rugged, and safe (QuEChERS) method, which has become a widely accepted design concept for pesticide residue analysis in various matrices [ 14 – 17 ]. Currently, several studies focused on the analysis of pesticide residue in PRA based on the QuEChERS method.…”

Section: Introductionmentioning

confidence: 99%

Removal of Matrix Interferences by Nano-MgO and Co-Adsorbents for Accurate Multi-Pesticide Residue Analysis in the Chinese Medicinal Herb, Paeoniae Radix Alba

Wang

et al. 2021

Journal of Analytical Methods in Chemistry

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A simple, accurate, and high-throughput analytical method was developed to detect 123 pesticide residues in Chinese medicinal herb Paeoniae Radix Alba (PRA) by introducing nano-MgO as a highly efficient purification material based on quick, easy, cheap, effective, rugged, and safe (QuEChERS) design concept. Various PRA samples were extracted using 8 mL 0.5% acetic acid-acetonitrile solution and purified by a dispersive solid-phase extraction method with 30 mg nano-MgO, 40 mg primary secondary amine (PSA), and 40 mg octadecylsilane (C18) as the cleanup adsorbents, followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). 70.7% of pesticides showed a weak matrix effect after the purification process, indicating that this method can give the precise quantitative analysis of trace pesticides residue. The method was systematically validated under optimal conditions in five different kinds of PRA samples; good linearity was observed in the concentration range of 0.5–250 μg/L or 1–250 μg/L. Pesticide recovery in each sample spiked at concentrations of 20, 50, and 200 μg/kg ranged from 98.0% to 111% and the mean relative standard deviation ranged from 2.72% to 5.70%. Furthermore, the method comparison with the traditional QuEChERS method suggested the feasibility, advantages, and potential application prospect of the present method for the multi-pesticide residue analysis in various PRA samples.

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Comparison of two extraction methods for the determination of 135 pesticides in Corydalis Rhizoma, Chuanxiong Rhizoma and Angelicae Sinensis Radix by liquid chromatography-triple quadrupole-mass spectrometry. Application to the roots and rhizomes of Chinese herbal medicines

Cited by 31 publications

References 29 publications

A comparison of the effectiveness of QuEChERS, FaPEx and a modified QuEChERS method on the determination of organochlorine pesticides in ginseng

A comparison of the effectiveness of QuEChERS, FaPEx and a modified QuEChERS method on the determination of organochlorine pesticides in ginseng

Simultaneous determination of 106 pesticides in nuts by LC–MS/MS using freeze‐out combined with dispersive solid‐phase extraction purification

Removal of Matrix Interferences by Nano-MgO and Co-Adsorbents for Accurate Multi-Pesticide Residue Analysis in the Chinese Medicinal Herb, Paeoniae Radix Alba

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