Comparison of Two Experimental Models for Urethral Stricture in the Anterior Urethra of the Male Rabbit

Faydaci, Gokhan; Tarhan, Fatih; Tuncer, Murat; Eryıldırım, Bilal; Celik, Osman; Keser, Sevinç Hallaç; Özgül, Aydın

doi:10.1016/j.urology.2012.04.025

Cited by 23 publications

(23 citation statements)

References 14 publications

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“…Although none of the rabbits in the electrocoagulation group had complications, urethral stricture was not developed. In contrast, in the electroresection group, although significant stricture formation was observed in every case, 60% of the rabbits had complications . In our injury model, all rabbits in group 3 (control) showed strictures and none had complications.…”

Section: Discussionmentioning

confidence: 61%

“…They were anesthetized with intramuscular ketamine hydrochloride (35 mg/kg) and xylazine (5 mg/kg). After they were placed in the dorsal position and retrograde urethrography was carried out to check the normal urethral width, their urethras were injured by electrocoagulation . The procedure of electrocoagulation in the bulbar urethra was carried out with spherical monopolar electrocautery.…”

Section: Methodsmentioning

confidence: 99%

“…After they were placed in the dorsal position and retrograde urethrography was carried out to check the normal urethral width, their urethras were injured by electrocoagulation. 21,22 The procedure of electrocoagulation in the bulbar urethra was carried out with spherical monopolar electrocautery. The spherical type electrode was inserted into the bulbar urethra from the external urethral meatus and used for 5 s of electrocoagulation at 40 W. Immediately after electrocoagulation, retrograde urethrography and urethroscopic observations were carried out to confirm the injured urethral segments.…”

Section: Experiments With Rabbit Urethral Injury Modelmentioning

confidence: 99%

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Insulin‐like growth factor 1 sustained‐release collagen on urethral catheter prevents stricture after urethral injury in a rabbit model

et al. 2019

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Objectives To evaluate the preventive effect of an insulin‐like growth factor 1 sustained‐release collagen urethral catheter on urethral stricture after urethral injury in a rabbit model. Methods We made urethral catheters coated either with insulin‐like growth factor 1 impregnated collagen or with only collagen, and we divided 19 male Japanese white rabbits into three groups according to the kind of catheter inserted immediately after the rabbit's urethra was injured by electrocoagulation. Group 1 (n = 7) had a catheter coated with insulin‐like growth factor 1 impregnated collagen inserted; group 2 (n = 7) had a catheter coated with only collagen inserted; and group 3 (n = 5) had an uncoated catheter inserted. A total of 14 days later, the injured urethras were evaluated by urethrography and urethroscopy, and were also histologically examined. Results Urethrography showed that the ratio of the urethral lumen diameter in injured urethra to that in normal urethra was the largest in group 1 (P < 0.0001). In addition, five of the seven rabbits in group 1 (71.4%) had a urethral lumen large enough for passage of a urethroscope, a fraction larger than the corresponding fractions in groups 2 (57.1%) and 3 (20%). On histological analysis, the injured area not covered with regenerated urethral epithelium tended to be smaller in group 1 than the other two groups, but the mean difference was not significant (P = 0.19). Conclusions An insulin‐like growth factor 1 sustained‐release collagen urethral catheter significantly improves wound healing and prevents urethral stricture after urethral injury.

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Section: Discussionmentioning

confidence: 61%

Section: Methodsmentioning

confidence: 99%

Section: Experiments With Rabbit Urethral Injury Modelmentioning

confidence: 99%

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Insulin‐like growth factor 1 sustained‐release collagen on urethral catheter prevents stricture after urethral injury in a rabbit model

et al. 2019

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“…Rabbit urethras were traumatized as described by Faydaci and associates. 15 Briefly, the animals were placed in a supine position, and their genitalia were scrubbed with povidoneiodine solution. A 13F pediatric resectoscope was used for the endoscopic operation.…”

Section: Methodsmentioning

confidence: 99%

Effect of Mitomycin, Bevacizumab, and 5-Fluorouracil to Inhibit Urethral Fibrosis in a Rabbit Model

Üyetürk

Gücük²,

Fırat³

et al. 2014

Journal of Endourology

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“…Rabbit and dog models of urethral stricture have recently been produced by open surgery, electroresection using a pediatric resectoscope, electrocoagulation with or without endoscopy, and bombing using a special instrument [7,8,9,10,11,12]. In twelve male minipigs stricture formation was established by ligation, urethrotomy or thermocoagulation [13].…”

Section: Introductionmentioning

confidence: 99%

An Experimental Model of Urethral Stricture in Rabbits Using Holmium Laser under Urethroscopic Direct Visualization

Zhang

et al. 2014

Urol Int

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Objective: To establish an experimental rabbit model of urethral stricture using holmium laser under direct urethroscopic visualization. Methods: Sixteen adult male New Zealand rabbits were divided into equally-sized control and experimental groups. All rabbits underwent retrograde urethrography and transurethral endoscopy with a 7.5 F urethroscope after intramuscular anesthetic injection. We used a holmium:YAG laser to injure the distal urethra in all rabbits in the experimental group under direct visualization. Thirty days after surgery, all animals were evaluated with retrograde urethrography and urethroscopy. The flow rate of the isolated urethras was measured to evaluate urethral stricture formation. Results: One rabbit in the experimental group (12.5%) died of infection 4 days after surgery. Thirty days after surgery, retrograde urethrography and urethroscopy revealed strictures in all seven surviving rabbits (87.5%) in the experimental group. The mean flow rate of the isolated urethras was significantly lower in the experimental group than in the control group. Conclusion: A rabbit model of urethral stricture can be successfully established using holmium laser under direct urethroscopic visualization, providing an ideal object for research concerning the pathogenesis and molecular biology of urethral strictures.

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Comparison of Two Experimental Models for Urethral Stricture in the Anterior Urethra of the Male Rabbit

Cited by 23 publications

References 14 publications

Insulin‐like growth factor 1 sustained‐release collagen on urethral catheter prevents stricture after urethral injury in a rabbit model

Insulin‐like growth factor 1 sustained‐release collagen on urethral catheter prevents stricture after urethral injury in a rabbit model

Effect of Mitomycin, Bevacizumab, and 5-Fluorouracil to Inhibit Urethral Fibrosis in a Rabbit Model

An Experimental Model of Urethral Stricture in Rabbits Using Holmium Laser under Urethroscopic Direct Visualization

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