Comparison of two dose regimens of ibuprofen for the closure of patent ductus arteriosus in preterm newborns

Dornelles, Laura Vargas; Corso, Andrea; Silveira, Rita de Cássia dos Santos; Procianoy, Renato Soibelmann

doi:10.1016/j.jpedp.2016.03.005

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…Considering observational studies, all 24 studies had a cohort design. Based on the Newcastle-Ottawa Quality Assessment Scale for this type of study design, 12 studies obtained a score of 9 out of [79-81, 84, 89, 91, 93-95, 97, 99, 101], nine had a score of [83,85,86,88,92,96,98,100,102], two studies a score of 7 [82,87], and one a score of 6 [90] (Appendix 6).…”

Section: Risk Of Biasmentioning

confidence: 99%

Efficacy and safety of pharmacological treatments for patent ductus arteriosus closure: A systematic review and network meta-analysis of clinical trials and observational studies

Marconi

Bettiol

Ambrosio

et al. 2019

Pharmacological Research

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Efficacy and safety profiles of different pharmacological interventions used to treat patent ductus arteriosus (PDA) are relatively unexplored. Integrating the findings of randomized clinical trials (RCTs) with those from observational studies may provide key evidence on this important issue.We aimed at estimating the relative likelihood of failure to close the PDA, need for surgical closure, and occurrence of adverse events among preterm and full-term infants treated with indomethacin, ibuprofen, or acetaminophen, placebo, or no treatment including both RCTs and observational studies.We searched PubMed, Embase, and the Register of Controlled Trials from inception to October 30, 2018. We first estimated proportions of subjects with failure to close the PDA, subjects in whom surgical closure was performed after pharmacological treatment, death, and subjects with selected adverse events (AEs). These estimates were obtained using frequentist random-effect meta-analysis of arm-specific proportions. We then compared active drugs with each other and with control (either placebo or no treatment) by summarizing results at the end of treatment reported in the papers, regardless of number of administration(s), dose, route and type of administration, and study design and quality. We also summarized primary outcome results separately at first, second and third cycles of treatment. These estimates were obtained using Bayesian random-effects network meta-analysis for mixed comparisons, and frequentist random-effect pairwise meta-analysis for direct comparisons.We included 64 RCTs and 24 observational studies including 14,568 subjects (5339 in RCTs and 9229 in observational studies, 8292 subjects received indomethacin, 4761 ibuprofen, 574 acetaminophen, and 941 control (including placebo or no intervention).The proportion of subjects with failure to close the PDA was 0.24 (95% Confidence Interval, CI: 0.20, 0.29) for indomethacin, 0.18 (0.14, 0.22) for ibuprofen, 0.19 (0.09, 0.30) for acetaminophen, and 0.59 (0.48, 0.69) for control . At end of treatment, compared to control, we found inverse associations between all active drugs and failure to close PDA (for indomethacin Odds Ratio, OR, was 0.17 [95% Credible Interval,

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Section: Risk Of Biasmentioning

confidence: 99%

Efficacy and safety of pharmacological treatments for patent ductus arteriosus closure: A systematic review and network meta-analysis of clinical trials and observational studies

Marconi

Bettiol

Ambrosio

et al. 2019

Pharmacological Research

View full text Add to dashboard Cite

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Prevalência de persistência do canal arterial em neonatos em um hospital público

Nascimento¹,

Silva²,

Oliveira

et al. 2019

Av. enferm.

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Objetivo: identificar a prevalência de persistência do canal arterial (PCA) em neonatos em um hospital público.Metodologia: trata-se de um estudo quantitativo, observacional e de caráter descritivo. Foram coletados dados de 313 prontuários de recém-nascidos, observando a ocorrência do diagnóstico de PCA em uma amostra de neonatosinternados em um hospital público do norte de Minas Gerais, Brasil no período de agosto de 2015 a agosto de 2016, até o 7º dia de vida. As seguintes variáveis foram analisadas: idade gestacional, peso ao nascer, Apgar 1’ e 5’, desconfortorespiratório, uso de equipamentos de suporte ventilatório e utilização de medicamentos para a função respiratória. Os dados coletados foram processados estatisticamente através do programa Minitab. Resultados: la incidência da PCA é maior em prematuro quando a relação idade gestacional e peso ao nascer são inversamente proporcionais à PCA. A prevalência neste estudo foi de 2,6 % de recém nascidos com a cardiopatia, sendo que destes foi observado o desconforto respiratório em 4,3 % neonatos.Conclusão: a prevalência do canal arterial na amostra foi relativamente baixa, dentre os fatores associados ao aparecimento da cardiopatia, mas as alterações no quinto minuto de Apgar mostraram ser estatisticamente significantes. Sendo assim, identificar a ocorrência do diagnóstico da PCA e conhecer as repercussões respiratórias, pode auxiliar na programação da assistência e, em especial, favorecer a melhoria da conduta de enfermagem.

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Comparison of two dose regimens of ibuprofen for the closure of patent ductus arteriosus in preterm newborns

Cited by 2 publications

References 22 publications

Efficacy and safety of pharmacological treatments for patent ductus arteriosus closure: A systematic review and network meta-analysis of clinical trials and observational studies

Efficacy and safety of pharmacological treatments for patent ductus arteriosus closure: A systematic review and network meta-analysis of clinical trials and observational studies

Prevalência de persistência do canal arterial em neonatos em um hospital público

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