Comparison of two different rectal spacers in prostate cancer external beam radiotherapy in terms of rectal sparing and volume consistency

Wolf, Frank; Gaisberger, Christoph; Ziegler, Ingrid; Krenn, Elisabeth; Scherer, Petra; Hruby, Stephan; Schätz, Tobias; Forstner, Rosemarie; Holzinger, Josef; Vaszi, Andrea; Kametriser, Gerhard; Steininger, Philipp; Deutschmann, H.; Sedlmayer, Felix

doi:10.1016/j.radonc.2015.07.027

Cited by 28 publications

(32 citation statements)

References 21 publications

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“…This indicates that the application of HS considerably decreased the amount of the anterior rectal volume being treated, with the mean rV 70 dropping from 12.5% to 7.8% for HS patients. Our present results are in accordance with other published studies and this has further validated our findings. Due to a broad range in prostate size, we also investigated the clinical benefits of HS in larger prostates.…”

Section: Discussionsupporting

confidence: 94%

Prospective analysis of hydrogel spacer for patients with prostate cancer undergoing radiotherapy

Chao

Ho²,

Chan

et al. 2018

BJU International

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Section: Discussionsupporting

confidence: 94%

Prospective analysis of hydrogel spacer for patients with prostate cancer undergoing radiotherapy

Chao

Ho²,

Chan

et al. 2018

BJU International

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“…To spare the rectum, two commercially available implantable rectum spacers (IRS) have been developed: one type based on polyethylene glycol hydrogels (SpaceOAR TM System, Augmenix Inc.) [6] and the other is a biodegradable saline-filled rectal balloon implant (BioProtect Ltd, Israel) [7,8]. These devices have been designed to increase the distance between the anterior rectal wall and the prostate, and pushing the rectal wall out of the high-dose region (Fig.…”

mentioning

confidence: 99%

Development of a virtual spacer to support the decision for the placement of an implantable rectum spacer for prostate cancer radiotherapy: Comparison of dose, toxicity and cost-effectiveness

Wijk¹,

Vanneste

Walsh

et al. 2017

Radiotherapy and Oncology

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“…Gold marker (GM) implantation, planning CT (3 mm slice thickness), and planning MRI were performed as previously described [ 17 ]. Prior to imaging, patients were instructed to have a full bladder and to empty their bowels using mild laxatives.…”

Section: Methodsmentioning

confidence: 99%

An IGRT margin concept for pelvic lymph nodes in high-risk prostate cancer

et al. 2017

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PurposeGold-marker-based image-guided radiation therapy (IGRT) of the prostate allows to correct for inter- and intrafraction motion and therefore to safely reduce margins for the prostate planning target volume (PTV). However, pelvic PTVs, when coadministered in a single plan (registered to gold markers [GM]), require reassessment of the margin concept since prostate movement is independent from the pelvic bony anatomy to which the lymphatics are usually referenced to.MethodsWe have therefore revisited prostate translational movement relative to the bony anatomy to obtain adequate margins for the pelvic PTVs compensating mismatch resulting from referencing pelvic target volumes to GMs in the prostate. Prostate movement was analyzed in a set of 28 patients (25 fractions each, totaling in 684 fractions) and the required margins calculated for the pelvic PTVs according to Van Herk’s margin formula .ResultsThe overall mean prostate movement relative to bony anatomy was 0.9 ± 3.1, 0.6 ± 3.4, and 0.0 ± 0.7 mm in anterior/posterior (A/P), inferior/superior (I/S) and left/right (L/R) direction, respectively. Calculated margins to compensate for the resulting mismatch to bony anatomy were 9/9/2 mm in A/P, I/S, and L/R direction and 10/11/6 mm if an additional residual error of 2 mm was assumed.ConclusionGM-based IGRT for pelvic PTVs is feasible if margins are adapted accordingly. Margins could be reduced further if systematic errors which are introduced during the planning CT were eliminated.

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Comparison of two different rectal spacers in prostate cancer external beam radiotherapy in terms of rectal sparing and volume consistency

Cited by 28 publications

References 21 publications

Prospective analysis of hydrogel spacer for patients with prostate cancer undergoing radiotherapy

Prospective analysis of hydrogel spacer for patients with prostate cancer undergoing radiotherapy

Development of a virtual spacer to support the decision for the placement of an implantable rectum spacer for prostate cancer radiotherapy: Comparison of dose, toxicity and cost-effectiveness

An IGRT margin concept for pelvic lymph nodes in high-risk prostate cancer

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