Comparison of two different radiation fractionation schedules with concurrent chemotherapy in head and neck malignancy

Alam, Mahtab; Perween, Roshan; Siddiqui, SA

doi:10.4103/0019-509x.197740

Cited by 7 publications

(6 citation statements)

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“…In the last 10 years the technical developments have remarkably increased the precision in RT treatment planning and RT delivery (Intensity Modulated RT-IMRT, Image Guided RT-IGRT, Tomotherapy) and have allowed radiation oncologists to use another type of altered fractionation called "hypofractiona¬tion" which employs daily dose (per fraction) of higher than 2 Gy, for instance 2.2-2.75 Gy or even higher [16,17]. All clinical trials and retrospective studies agree that tumor control is at least equivalent to standard fractionation and the post-radiation effects are rather reduced [18][19][20][21][22], let alone the favorable consequences of the lower number of RT fractions (see previous paragraph). Clinical radiobiology methods and the Linear-Quadratic formulation predict a better clinical outcome with HFX.…”

Section: Radiobiological Considerationsmentioning

confidence: 99%

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"Radical Radiotherapy for Early-Stage Carcinoma of the Glottis. Should We Switch to Hypofractionation?"

Georgios

2023

BJSTR

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Introduction:We present our current experience regarding radiotherapy (RT) of early glottic cancer, and we investigate the possibility for further improvement with hypofractionation.Methods: Patients treated between May 2016 and October 2021 with definitive radiotherapy for T1-2 N0 squamous-cell carcinoma of the glottis were reviewed retrospectively. The probabilities of local control, ultimate local control (after salvage surgery), cause specific survival (CSS) and overall survival (OS) are presented. Results:We report on 57 treated patients, with median age of 68 years (49 to 88 years). The median follow-up time was 46 (12 to 74) months. 20 (35.1%), 13 (22.8%) and 24 (42.1 %) of patients had T1a, T1b and T2 disease respectively. Five-year actuarial local control rates were as follows: T1 90.9 %, T2 79.2 % (p=0.205) and overall 86%. Local control rates after salvage surgery were: T1 97 % and T2% 95.8% (p=0.887) and overall 96.5 %. Five-year disease specific survival and overall survival were 96.5% and 86% respectively. There were no significant associations with T-stage, overall treatment time, histological grade with local control on univariate analysis. Only 2 patients (3.5 %) required short-term parenteral nutrition during radiotherapy. One patient required a tracheostomy due to a non-functioning larynx one year post radiotherapy. Second primary cancers developed in 17.5 % of patients. Conclusion:Our results show that there might be room for improvement for both T1 and T2, but especially T2-staged tumors. A reasonable way to investigate, is the employment of hypofractionation (HFX) RT.

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Section: Radiobiological Considerationsmentioning

confidence: 99%

“…Where D: total radiation dose of 66 Gy, d: dose per fraction 2 Gy, α/β ratio= 6 Gy (the median between 4 and 8 as per Sharon Qi et al [22]), T= 46 days (6.5 weeks), Tpot: potential doubling time= 3 days, α = 0.3 Gy-1, Tk the time by which tumor repopulation starts= 21 days [24].…”

Section: Radiobiological Considerationsmentioning

confidence: 99%

"Radical Radiotherapy for Early-Stage Carcinoma of the Glottis. Should We Switch to Hypofractionation?"

Georgios

2023

BJSTR

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“…RT was used for both curative as well as palliative goals. [1][2][3] It was thought that about 80% of cancer patients who were cured by a combination of treatments, while almost 20% were cured by RT alone. 4 Overall, nearly 60%-70% of all cancer patients require RT during their treatment course.…”

Section: Introductionmentioning

confidence: 99%

Patient wait times for daily outpatient radiotherapy appointments (a single-centre study)

Roy

Sarkar²,

Pradhan³

et al. 2023

J Radiother Pract

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Purpose: Patient wait time for every single fraction of every patient treated at our centre for the past year has been presented in this study. The waiting time data were analysed across different treatment sites and modalities. Materials and Methods: Between March 2021 and March 2022, all patients and their corresponding recorded measurements of waiting time were analysed. Times recorded included check-in time (CK), scheduled time to start treatment (SC) and beam-on time for the first beam of therapy (ST). SPSS version 18 was used for statistical calculations, correlations and assessing significance. Results: A total of 181 patients were treated during this duration. The total number of radiotherapy (RT) sessions recorded was 3011. Out of these 3011 sessions, number of times treated by rapid arc (RA), intensity-modulated radiotherapy (IMRT), three-dimensional conformal radiotherapy (3DCRT), stereotactic body radiotherapy (SBRT), stereotactic radiosurgery and stereotactic radiotherapy (SRS/SRT) were 68.18%, 30.19%, 0.167%, 0.565% and 0.19%, respectively. The mean (± standard deviation) times for scheduled time to start treatment (SC) to check-in time (CK), SC to ST (beam-on time for the first beam of treatment), CK to ST and (CK or SC) to ST were −14 ± 48 min, 6 ± 50 min, 19 ± 24 min and −4 ± 31 min, respectively. Conclusion: Patient wait times during RT were presented in this study. This study covered the daily waiting times before RT during modern-day RT treatment sessions. This vast series of consecutive patient data will be a valuable resource for the future planning and management of any modern RT department.

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“…All the patients were staged according to the international tumour-nodemetastases classification of the American Joint Committee on Cancer. [3] The Inclusion Criteria included patients presenting with stage III and IV Head and Neck cancers with good performance status, not treated previously with any modality, with biopsy proven squamous cell carcinoma, 30 -70 years' age group, adequate haemoglobin status above 10 gm/dL and adequate nutritional status.…”

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confidence: 99%

Comparison of Hyperfractionation and Conventional Method of Radiotherapy in Head and Neck Cancers

Bakthavachalam¹,

Yen²

2017

jemds

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Comparison of two different radiation fractionation schedules with concurrent chemotherapy in head and neck malignancy

Abstract: Accelerated fractionation regimen was not more efficacious than conventional fractionation in the treatment of previously untreated head and neck carcinoma.

Cited by 7 publications

References 1 publication

"Radical Radiotherapy for Early-Stage Carcinoma of the Glottis. Should We Switch to Hypofractionation?"

"Radical Radiotherapy for Early-Stage Carcinoma of the Glottis. Should We Switch to Hypofractionation?"

Patient wait times for daily outpatient radiotherapy appointments (a single-centre study)

Comparison of Hyperfractionation and Conventional Method of Radiotherapy in Head and Neck Cancers

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