Comparison of Two Anticoagulants for Pain Associated with Platelet-Rich Plasma Injections

Görğü, Metin; Gökkaya, Ali; Doğan, Ali

doi:10.1007/s00266-019-01541-z

Cited by 8 publications

(4 citation statements)

References 25 publications

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“…Compared with using sodium citrate (Na-citrate) to prepare PRP, using acid citrate dextrose-A as an anticoagulant for PRP preparation can reduce the pain felt by patients during PRP injection. 22 …”

Section: Methodsmentioning

confidence: 99%

The Application of Blood Products in Plastic Surgery: A Systematic Review

Zhuang,

Chen,

Zheng

et al. 2024

Plastic and Reconstructive Surgery - Global Open

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Background: Due to their minimal trauma and relative safety, blood products are becoming increasingly popular in medical aesthetics. In recent years, research on the application of blood products has also been increased. This article will summarize the research progress of emerging blood products in plastic surgery in recent years. Methods: We searched the PubMed database for literature related to the application of blood preparation in plastic surgery over the past 5 years and summarized them. Results: Commonly used in plastic surgery are platelet-rich plasma, platelet-rich fibrin, concentrated growth factor, platelet-poor plasma, and mesenchymal stem cells derived from blood products. They can be used for wound repair and skin and autologous fat transplantation, and can be combined with laser therapy and facial rejuvenation. Conclusions: Understanding the application pathways of blood products in plastic surgery and their respective advantages and disadvantages can help us better choose and use them.

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Section: Methodsmentioning

confidence: 99%

The Application of Blood Products in Plastic Surgery: A Systematic Review

Zhuang,

Chen,

Zheng

et al. 2024

Plastic and Reconstructive Surgery - Global Open

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“…This proactive communication allows for informed consent and empowers patients to manage post-treatment experiences effectively. Clinicians can implement supportive measures to alleviate discomfort, enhance the overall patient experience, and foster a positive perception of PRP therapy [ 25 ].…”

Section: Reviewmentioning

confidence: 99%

A Comprehensive Review of Platelet-Rich Plasma and Its Emerging Role in Accelerating Bone Healing

Gharpinde,

Pundkar,

Shrivastava

et al. 2024

Cureus

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This comprehensive review delves into the emerging role of platelet-rich plasma (PRP) in accelerating bone healing. PRP, a blood-derived product rich in platelets and growth factors, has garnered attention for its regenerative potential. The review begins by defining PRP and providing a historical background, highlighting its significance in expediting bone healing. PRP's composition and preparation methods, including centrifugation techniques and commercial kits, are explored. Mechanistically, PRP operates by releasing growth factors, chemotaxis, and angiogenesis, elucidating its cellular effects. Applications in fracture healing and orthopaedic surgeries, such as joint arthroplasty and spinal fusion, are discussed, emphasising the promising outcomes in clinical trials. Safety considerations, patient selection criteria, and the need for PRP preparation and application standardisation are underscored. The review outlines ongoing research trends, potential technological advancements, and unexplored areas in paediatric applications and inflammatory bone disorders. The implications for clinical practice involve informed decision-making, optimised protocols, and interdisciplinary collaboration. In conclusion, the future of PRP in bone healing holds exciting prospects, with the potential for precision medicine, integration with emerging therapies, expanded applications, and enhanced technological innovations shaping its trajectory in orthopaedics and regenerative medicine.

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“…Sodium citrate was chosen as citrate-based anticoagulants are fully reversible. In comparison to ACD-A (acid citrate dextrose solution A) which is an acidic (pH 4.5-5) anticoagulant often used for PRP preparation, sodium citrate has the advantage of having a neutral pH (pH 7) and contains no sugar [15]. Sodium citrate is more physiological and has no ancillary effect on the patient.…”

Section: Anticoagulantmentioning

confidence: 99%

Swiss Medical Devices for Autologous Regenerative Medicine: From Innovation to Clinical Validation

Gomri¹,

Vischer²,

Turzi³

et al. 2022

Pharmaceutics

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Regenerative medicine, based on the use of autologous tissues and embryonic, stem or differentiated cells, is gaining growing interest. However, their preparation, in a manner compliant with good practices and health regulations, is a technical challenge. The aim of this manuscript is to present the design of reliable CE marked medical devices for the preparation of standardized platelet-rich plasma (PRP) and other autologous biologics intended for therapeutic uses. There are numerous PRP isolation processes. Depending on the methodology used, PRP composition varies greatly in terms of platelet concentration, platelet quality, and level of contamination with red and white blood cells. This variability in PRP composition might affect the clinical outcomes. The devices presented here are based on a specific technology, patented all over the world, that allows the precise separation of blood components as a function of their density using thixotropic separator gels in closed systems. This allows the preparation, in an automated manner, of leukocyte poor PRP with a standardized composition. Production of different forms of PRP is a clinical asset to suit various therapeutic needs. Therefore, we are offering solutions to prepare PRP either in liquid or gel form, and PRP combined with hyaluronic acid. These biologics have been successfully used in many different therapeutic domains, resulting in more than 150 published clinical studies. We also developed the CuteCell technology platform for cell culture expansion for further autologous cell therapies. This technology enables the safe and rapid in vitro expansion of cells intended for therapeutic use in good manufacturing practices (GMP) and autologous conditions, using blood-derived products as culture media supplementation. We summarize in this article our 20 years’ experience of research and development for the design of PRP devices and, more recently, for PRP combined with hyaluronic acid.

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Comparison of Two Anticoagulants for Pain Associated with Platelet-Rich Plasma Injections

Cited by 8 publications

References 25 publications

The Application of Blood Products in Plastic Surgery: A Systematic Review

The Application of Blood Products in Plastic Surgery: A Systematic Review

A Comprehensive Review of Platelet-Rich Plasma and Its Emerging Role in Accelerating Bone Healing

Swiss Medical Devices for Autologous Regenerative Medicine: From Innovation to Clinical Validation

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