Comparison of Two Anesthetic Methods for Intravitreal Ozurdex Injection

Karabaş, V. Levent; Özkan, Berna; Koçer, Çiğdem Akdağ; Altıntaş, Özgül; Pirhan, Dilara; Yüksel, Nurşen

doi:10.1155/2015/861535

Cited by 8 publications

(11 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are some studies which compared the effectiveness of various anesthetic methods or agents for IVIs. 23–25 Still, no anesthesia technique for this procedure has been proven to eliminate pain completely.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation effectiveness of 0.1% nepafenac on injection-related pain in patients undergoing intravitreal Ozurdex injection

Oğurel

Oğurel²,

Özkal

et al. 2019

Ophthalmol Eye Dis

View full text Add to dashboard Cite

Purpose: To evaluate the analgesic effect of topical 0.1% nepafenac solution during intravitreal Ozurdex injection. Methods: This prospective, randomized, double-blind placebo-controlled study included 59 patients who were diagnosed with retinal vein occlusion or pseudophakic cystoid macular edema and were selected to receive intravitreal Ozurdex injection. The patients were divided into two groups. Group 1, consisting of 31 eyes of 31 patients, received topical 0.1% nepafenac with topical anesthesia (0.5% proparacaine HCl, Alcaine; Alcon, TX, USA), and group 2, consisting of 28 eyes of 28 patients, received placebo with topical anesthesia. Results: There were 14 (45.2%) men and 17 (54.8%) women in group 1 and 16 (57.1%) men and 12 (42.9%) women in group 2. The mean age of the subjects was 64.42 ± 5.51 years in group 1 and 62.32 ± 7.54 years in group 2. The median visual analog scale pain score was 2 (1–3) in group 1 and 4 (1–6) in group 2. The visual analog scale pain score was significantly lower in group 1 than in group 2 ( p < 0.001). Conclusion: Topical 0.1% nepafenac has an additive analgesic effect when combined with topical anesthesia for intravitreal Ozurdex injection.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Also, there is a study that evaluated anesthetic methods for intravitreal Ozurdex injection. Karabaş and colleagues 25 compared topical proparacaine drops and lidocaine-applied pledget with subconjunctival lidocaine injection and found that there was no difference in pain scores.…”

Section: Discussionmentioning

confidence: 99%

Evaluation effectiveness of 0.1% nepafenac on injection-related pain in patients undergoing intravitreal Ozurdex injection

Oğurel

Oğurel²,

Özkal

et al. 2019

Ophthalmol Eye Dis

View full text Add to dashboard Cite

show abstract

“…In addition to the aforementioned factors, there have been some reports on differences in the degree of pain according to age [ 8 14 16 ], type of anaesthetic [ 4 7 11 21 ], and location of injection [ 12 22 ]. Rifkin and Schaal [ 14 ] reported that older patients perceived more pain during intravitreal injections; however, others reported that older patients were associated with lower degree of pain [ 8 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have investigated the degree of pain following intravitreal injections [ 6 7 8 9 10 11 12 13 ]. However, in most studies, the pain associated with a single injection was measured.…”

mentioning

confidence: 99%

Factors Associated with Pain Following Intravitreal Injections

Shin

Park

Kim

2018

Korean J Ophthalmol

View full text Add to dashboard Cite

PurposeTo investigate factors associated with pain intensity following intravitreal injection and factors that might be associated with changes in pain intensity in patients who received repeated injections.MethodsA total of 172 eyes (147 patients) were prospectively enrolled. Patients rated their pain from 0 to 10 using a visual analogue scale. Multiple linear regression analysis was used to evaluate factors associated with pain score. Sixty-eight patients evaluated their degree of pain more than once and were divided into three groups according to changes in pain during repeated injections. Clinical factors were compared among the three groups.ResultsPain scores of women (women, 3.1 ± 1.5 vs. men, 2.4 ± 1.2; p = 0.003), those who received dexamethasone implant injection (dexamethasone implant, 3.5 ± 1.1 vs. anti-vascular endothelial growth factor, 2.7 ± 1.4; p = 0.028), and those who did not undergo anterior chamber paracentesis (ACP) (ACP, 2.6 ± 1.3 vs. no ACP, 3.0 ± 1.6; p = 0.047) were significantly higher than those of the other groups. On multiple linear regression analysis, only female sex and ACP were significantly associated with degree of pain. The waiting time during the second injection was significantly associated with change in degree of pain in patients who received repeated injections.ConclusionsWomen were more prone to perceive pain, and the ACP procedure reduced pain during intravitreal injections. Most patients who received repeated injections felt that pain was similar or decreased compared to that experienced during the previous injection. However, increased waiting time might have been associated with increased discomfort for patients who received repeated injections.

show abstract

“…Similarly, Karabas et al did not find any notable differences in pain score in patients who received anesthetic pledgets versus pledgets with a subconjunctival anesthetic injection. 22 Kaderli et al evaluated pain both after administration of the anesthetic and after the IVI. 23 The study found that patients rated the pain of the IVI as statistically significantly lower when given a subconjunctival injection as compared to topical pledget.…”

Section: Injected Anesthetics Subconjunctival Anestheticmentioning

confidence: 99%

<p>Anesthesia for Intravitreal Injection: A Systematic Review</p>

Han¹,

Rinella²,

Chao³

2020

OPTH

View full text Add to dashboard Cite

Background: The intravitreal injection has become one of the most commonly performed procedures in ophthalmology; however, there is no standardized approach to anesthesia during the procedure. The goal of this systematic review is to review approaches to anesthesia for intravitreal injection and look at comparative efficacy between these different anesthetics. Methods: A systematic review of literature was performed in the MEDLINE, PubMed, Cochrane Library, and Clinicaltrials.gov databases using the key words "anesthesia", "pain management", and "intravitreal injection". Of the initial 239 search matches, 30 articles were found to be relevant to the topic. 18 studies were excluded as they did not include primary data or did not include the visual analog scale as a primary outcome. The remaining 12 articles were assessed to look at the comparative efficacy of anesthesia and adverse events. Results: The anesthesia techniques reported include topical methods such as anesthetic eyedrops, anesthetic gels, and anesthetic-soaked pledgets as well as subconjunctival injection of anesthetic. Ultimately, no single anesthetic or delivery mechanism was shown to be superior to the others in a statistically significant way and adverse events were largely insignificant. Limitations of these studies include relatively small sizes of the studies, as well as the lack of masking which may introduce bias. Conclusion: In the current literature, no type of anesthetic method was found to be superior to another for intravitreal injection. Future studies in this area may lead to new insights into the efficacy of different forms of intravitreal anesthesia.

show abstract

Comparison of Two Anesthetic Methods for Intravitreal Ozurdex Injection

Cited by 8 publications

References 22 publications

Evaluation effectiveness of 0.1% nepafenac on injection-related pain in patients undergoing intravitreal Ozurdex injection

Evaluation effectiveness of 0.1% nepafenac on injection-related pain in patients undergoing intravitreal Ozurdex injection

Factors Associated with Pain Following Intravitreal Injections

<p>Anesthesia for Intravitreal Injection: A Systematic Review</p>

Contact Info

Product

Resources

About