Comparison of TTS-fentanyl with sustained-release oral morphine in the treatment of patients not using opioids for mild-to-moderate pain

Abstract

These data indicate that TTS-fentanyl, when used as an opioid of first choice in the treatment of cancer-related pain, is as effective as, but better tolerated than, SRM, including in opioid-naïve patients.

Is the use of transdermal fentanyl inappropriate according to the WHO guidelines and the EAPC recommendations? A study of cancer patients in Italy

“…Van Seventer et al [22] compared the efficacy and tolerability of transdermal fentanyl and orally administered sustained-release morphine (SRM) in both opioid-naïve patients with moderate to severe cancer-related pain and in patients who had already been using opioids for mild to moderate pain. The results of the study show that TF, when used as first-choice strong opioid, was as effective from the analgesic point of view as SRM, including that of opioidnaïve patients.…”

Transdermal Opioids for Cancer Pain Management

“…15,16 Furthermore randomised, controlled, open-label trials suggest that transdermal fentanyl is safe and as effective as SROM in the treatment of chronic cancer pain. [15][16][17] Hence significantly more patients expressed a preference for transdermal fentanyl at the end of a randomised controlled, openlabel crossover trial. 18 Buprenorphine Buprenorphine is a semi-synthetic compound derived from thebaine, a natural opium alkaloid.…”

Complete Atrioventricular Block Associated with Transdermal Fentanyl Treatment for Cancer Pain

“…Günümüzde sıklığı giderek artan transdermal kullanım ile daha az yan etki ile daha iyi ağrı kontrolü sağlanmakta ve bu sayede hastaların yaşam kalitesi artmaktadır (3,4) . Transdermal fentanil (TDF) kullanımının en sık görülen yan etkileri sedasyon, bulantı-kusma ve kabızlıktır (5) . Bu sunumda, son dönem akciğer kanseri nedeniyle transdermal fentanil tedavisi uygulanan bir hastada akut gelişen, hemodinamiyi bozan ve fentanil tedavisinin kesilmesi ile kendiliğinden normal sinüs ritmine dönen bir olgu sunulmuştur.…”