Comparison of triglyceride glucose index, and related parameters to predict insulin resistance in Korean adults: An analysis of the 2007-2010 Korean National Health and Nutrition Examination Survey

Abstract

The triglyceride glucose (TyG) index, a product of triglyceride and fasting glucose, is a reliable marker for insulin resistance (IR). Obesity is also known to be closely related with IR. Recently, the efficiency of TyG-related markers that combine obesity markers with TyG index has been studied; however, earlier studies were limited in number and the results were inconsistent. Therefore, in this study, we investigated the efficiency of several combinations of TyG index and obesity indices, namely, body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR), in reflecting IR. Data were obtained from the Korean National Health and Nutrition Examination Survey from 2007–2010. A total of 11,149 subjects (4,777 men and 6,372 women) were included. IR was defined as the homeostasis model assessment for IR (HOMA-IR) of above the 75 th percentile for each gender. Logistic regression analysis was performed after adjusting for confounding factors, to compare and identify the associations of the 4 parameters (TyG index, TyG-BMI, TyG-WC, and TyG-WHtR) with IR. For each parameter, odds ratios (OR) and 95% confidence intervals (CIs) of quartiles 2–4 were calculated and compared with quartile 1 as a reference. A receiver operating characteristic (ROC) curve analysis was conducted to evaluate the ability of each parameter to predict IR. The adjusted ORs of quartile 4 in comparison with quartile 1 (95% CIs) for IR were 7.60 (6.52–8.87) for TyG index, 12.82 (10.89–15.10) for TyG-BMI, 16.29 (13.70–19.38) for TyG-WC, and 14.86 (12.53–17.62) for TyG-WHtR. The areas under the ROC curve for each parameter were 0.690 for TyG index, 0.748 for TyG-BMI, 0.731 for TyG-WC, and 0.733 for TyG-WHtR. In conclusion, TyG-BMI was found to be superior to other parameters for IR prediction. We propose TyG-BMI as an alternative marker for assessing IR in clinical settings.

Diagnostic Accuracy of the Triglyceride and Glucose Index for Insulin Resistance: A Systematic Review

“…In 10 studies, comprising a total of 63,500 subjects, TyG index diagnostic performance was evaluated using the HOMA-IR index as the reference test [7,12,[14][15][16][17][18][19][20][21]. e cutoff values were reported in 5 (4.55-4.78) with sensitivity and specificity values ranging from 73% to 90% and 45% to 99%, respectively (Table 3).…”

“…In studies using HIEC, diagnostic performance varied with the insulin infusion rate and cutoff value. International Journal of Endocrinology [5] HIEC M rate (insulin 50 mU/min/m 2 ) 6.39 mg/min/kgFFM Simental-Mendía, [7] HOMA-IR Previous literature ≥2.8 Du, [14] HOMA-IR >75th percentile 3.5 Lee, [15] HOMA-IR >75th percentile 2.52 Er, [16] HOMA-IR >75th percentile 2.43 Guerrero-Romero, [12] HOMA-IR Not specified ≥2.9 Mazidi, [17] HOMA-IR Not specified ≥2.5 ota, [18] HOMA-IR Not specified NR Lim, [19] HOMA-IR >75th percentile NR Dorota-Łojko, [20] HOMA-IR Previous literature ≥2.0 Salazar, [21] HOMA-2IR ≥2.0 ≥2.0 IR: insulin resistance; HC: hyperglycemic clamp; HIEC: hyperinsulinemic-euglycemic clamp; FFM: free-fat mass; NR: not reported; M � male; F � female; PreF � premenopausal female; PF � postmenopausal female.…”

Triglyceride-Glucose Index and Related Parameters Predicted Metabolic Syndrome in Nigerians

“…11 Furthermore, TyG index is strongly associated with, and performed better than HOMA-IR in identifying MS. 12 Finally, TyG-related parameters such as product of TyG and waist circumference (TyG-WC), TyG and waist-to height ratio (TyG-WHtR), TyG and waist-to-hip ratio (TyG-WHpR), and TyG and body mass index (TyG-BMI) improved identification of people with IR. 13 Previous studies that evaluated the usefulness of TyG index were conducted among Americans, Caucasians, and Asians. Blacks have low TG despite the high rates of CVDs, the socalled metabolic paradox.…”

Body composition patterns among normal glycemic, pre-diabetic, diabetic health Chinese adults in community: NAHSIT 2013–2016

“…First, we analyzed the association between body composition markers and different blood glucose and HbA1c levels by excluding patients of diabetes mellitus with medical treatment. Second, we investigated the relationship between body composition markers and insulin resistance (IR) by triglyceride glucose-waist circumference index (TyG-WC index) [ 24 , 25 ]. The TyG and TyG-related markers have been used as the surrogate indicators for IR [ 25 , 26 ].…”

“…Second, we investigated the relationship between body composition markers and insulin resistance (IR) by triglyceride glucose-waist circumference index (TyG-WC index) [ 24 , 25 ]. The TyG and TyG-related markers have been used as the surrogate indicators for IR [ 25 , 26 ]. Of these markers, the TyG-WC index was more accurate in estimating IR [ 25 ].…”