Comparison of Treatment Outcome of Antihypertensive Drugs in the Management of Pregnancy Induced Hypertension

Abstract

This study was aimed to find out the differences in the pregnancy outcome of PIH women treated with the antihypertensive drugs methyldopa and nifedipine. The prospective observational study was conducted in a multi specialty hospital at Coimbatore with 161 PIH diagnosed women. Women were categorised into the no-drug group, methyldopa group, nifedipine group and methyldopa with nifedipine group. All the women were monitored from diagnosis to delivery. The maternal and neonatal data were collected and analysed. The drugs were significantly controlled the blood pressure (BP) from base to end (P<0.001). There was no significant difference in the reduction of BP between the drugs. Cesarean delivery (>90%) and preterm delivery were high across all the groups. No significant difference was seen between these groups. The AGA (Average for gestational age) babies were significantly higher with a no-drug group (83%) and lower with nifedipine group (40%). Two women were reported with HELLP syndrome in methyldopa with nifedipine group. No significant difference was found in terms of pregnancy outcome between these groups except for eclampsia and AGA. Eclampsia was affected more with 14% in methyldopa with nifedipine group. We found similar outcomes; there were no significant changes between methyldopa, nifedipine, and the no-drug treatment. The antihypertensive drugs nifedipine and methyldopa both were significantly reduced the BP. The maternal and neonatal complications were similar between these two drugs. No beneficial effect can be identified one over another. Pregnancy-induced hypertension (PIH) is associated with the various problems in pregnancy outcome. The complications of high blood pressure (BP) during pregnancy are detrimental [1]. The elevated or uncontrolled BP leads to early and cesarean delivery also caused various complications to both mother and fetus. Indeed, the PIH resolves postpartum it causes various maternal and fetal morbidity and mortality [2]. Growth retardation and fetal mortality are the serious complications in PIH pregnancy. The development of PIH often required medications to control the BP. Antihypertensive drugs are used to control the BP within the normal range which further reduces the PIH related complications. Although various drugs are used to treat the PIH, the benefits of antihypertensive medication in PIH is inconsistent [3] and the use of antihypertensive medication as well as treatment targets in PIH remains controversial [4]. The chosen drug should be safe and effective to both mother and fetus in terms of reduction in PIH complications. Hence this study was planned to find out the differences in treatment outcome between the different types of antihypertensive drugs used in the treatment of PIH.The study was approved by the Institutional ethics committee (EC/AP/102/09-2009, Date: 12-08-2009) at kovai medical center and hospital, Coimbatore, Tamilnadu, India. The observational study was carried out at kovai medical center and hospital from January 2009 to December 2014. A ...

Comparison effectiveness of use antihypertensive in preeclampsia patient in RSUD Panembahan Senopati Bantul

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