Comparison of travoprost 0.0015% and 0.004% with timolol 0.5% in patients with elevated intraocular pressure

Clinical utility and differential effects of prostaglandin analogs in the management of raised intraocular pressure and ocular hypertension

“…250 A study of 605 patients (excluding subjects with ocular trauma or incisional eye surgery) reported no CME with travoprost use. 122 In 163 eyes of 84 consecutive patients with uveitis and raised IOP, there was no increase in the frequency of visually significant CMO (P = 0.19) or anterior uveitis (P = 0.87) with PGA treatment compared with no PGA treatment. 259 Although CME risk appears extremely low to non-existent in low-risk eyes (no intraocular surgery or uveitis) 260 and that even high risk eyes have relatively low incidence, caution should still be exercised during use in high risk eyes.…”

“…Difference in %IOPR was 6%; IOPR% was 27.2% for PGA use (collectively) 63 85,86,92,93,95 (WMD = 0.08, P = 0.8) or latanoprost 0.005% 68,85,93,95,98,104 (WMD = −0.57, P = 0.07), but superior to timolol. 68,121,122,144 In summary, the vast majority of studies support IOPlowering superiority of latanoprost, 71,73,81,106 travoprost, 121,122 and bimatoprost, 124,125,137 over timolol, and although not entirely consistent. 72 PGAs were effective in eyes unresponsive or inadequately controlled with timolol, and remained effective long term.…”

Pressure Lowering Medications

“…It is believed through unknown mechanism, travaprost increase outflow through mainly unconventional pathway with some effect on conventional pathway (Torris et al, 2008). Unlike latanoprost, travaprost provides prolong pressure lowering effect up to 40 hours post single instillation (Fellman et al, 2002). Travoprost is reported to provide up to 28% pressure reduction from baseline, which is almost similar to latanoprost and significantly superior to timolol (Netland et al, 2001).…”

The reduction of intraocular pressure after instillation of travoprost compared with timolol in chronic primary angle-closure glaucoma

“…5 Another prostaglandin analog is Travoprost which also showed effectiveness in lowering IOP on primary open angle glaucoma and ocular hypertension. [6][7][8] During sixmonth trial in a clinical testing phase III, Travoprost was found to be more effective in reducing IOP compared to timolol. The IOP reduction was about 30% -33% or an average of less than 17 mmHg, and there was no tendency for IOP to rise.…”

“…The IOP reduction was about 30% -33% or an average of less than 17 mmHg, and there was no tendency for IOP to rise. 6 Pivotal studies showed that Travoprost was an effective single therapy and optimal effect was achieved when Travoprost was given at night. [4][5][6][7] In an other study comparing Travoprost, latanoprost and bimatoprost for 12 weeks on subjects with primary open angle glaucoma and ocular hypertension, all three drug were found to have the same potency in reducing IOP, but no study of the effect of Travoprost on primary angle closure glaucoma has been done.…”