Comparison of transmissibility of coronavirus between symptomatic and asymptomatic patients: Reanalysis of the Ningbo Covid-19 data

Yin, Guosheng; Jin, Huaqing

doi:10.1101/2020.04.02.20050740

Cited by 20 publications

(27 citation statements)

References 5 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Asymptomatic cases with COVID-19 are of great concern. They contribute to the spread of SARS-CoV-2, 23 with similar transmission rates as symptomatic patients, 24 while the virus replicates in their lower respiratory tract resulting in radiological evidence of infection. 25 Reports show that asymptomatic cases with normal chest CT have shorter periods from diagnosis to being SARS-CoV-2 negative than asymptomatic cases with positive chest CT. 26 COVID-19 should be considered among cases with CT abnormalities even when there are no other symptoms.…”

Section: Discussionmentioning

confidence: 99%

Chest CT findings in asymptomatic cases with COVID-19: a systematic review and meta-analysis

et al. 2020

View full text Add to dashboard Cite

To determine the overall rate of chest imaging findings in asymptomatic cases, describe the most common patterns found, and determine the rate of later symptom development in these initially asymptomatic cases. MATERIALS AND METHODS: The PubMed and EMBASE databases were searched until 1 May 2020, for studies examining the proportion of positive chest imaging findings in asymptomatic cases diagnosed with COVID-19 and a random-effects meta-analysis of proportions was performed. Heterogeneity was assessed using the I 2 statistic. RESULTS: Among 858 non-duplicate studies, seven studies with a total of 231 asymptomatic cases met the inclusion criteria. In the primary analysis, the pooled estimate of the overall rate of positive chest computed tomography (CT) findings among asymptomatic cases was 63% (95% confidence interval [CI]: 44e78%). Among 155/231 cases that were followed up for later symptom development, 90/155 remained asymptomatic and 65/155 developed symptoms during the study period (that ranged between seven and 30 days of follow-up). The pooled estimate of the rate of positive chest CT findings was 62% (95% CI: 38e81%) in cases that remained asymptomatic, while it was 90% (95% CI: 49e99%) in cases that developed symptoms. Among CT findings, the pooled estimate of the overall rate of ground-glass opacities (GGO) at CT alone was 71% (95% CI: 50e86%). Among other CT findings reported, 22/231 patients had GGO with consolidation, 7/231 patients had stripe shadows with or without GGO, and 8/231 patients had GGO with interlobular septal thickening. Among initially asymptomatic cases with positive CT findings, the pooled estimate of the overall rate of later symptom development was 26% (95% CI: 14e43%). CONCLUSION: In COVID-19, asymptomatic cases can have positive chest CT findings, and COVID-19 should be considered among cases with CT abnormalities even when there are no other symptoms. There is a need for close clinical monitoring of asymptomatic cases with radiographic findings as a significant percentage will develop symptoms.

show abstract

Section: Discussionmentioning

confidence: 99%

Chest CT findings in asymptomatic cases with COVID-19: a systematic review and meta-analysis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…15 Another study conducted by the Department of Statistics and Actuarial Science of the University of Hong Kong concluded that there was no difference in the transmission rates of coronavirus between symptomatic patients and asymptomatic cases. 16 Overall, these studies provided evidence that the risk of transmission by asymptomatic patients might be not lower than that by symptomatic patients. Moreover, some individuals infected with the virus experience no or only mild symptoms, and they might be unaware of their disease and thus not isolate themselves or seek treatment.…”

mentioning

confidence: 86%

Asymptomatic SARS-CoV-2 infections: What do we need to know?

Tan

Xiao

Meng

et al. 2020

Infect. Control Hosp. Epidemiol.

View full text Add to dashboard Cite

show abstract

“…Chen et al (36) followed up and investigated 2,147 close contacts in Ningbo, Zhejiang, China, with a total infection rate of 6.15%, while there was no significant difference in the infection rate between the confirmed cases and asymptomatic cases (6.30 and 4.11%, respectively) (36). Concomitantly, Yin and Jin (37) analyzed the transmission rate of 157 symptomatic cases and 30 asymptomatic cases of COVID-19 and identified that there was no significant difference in the transmission rate between symptomatic and asymptomatic patients. However, none of these studies excluded pre-symptomatic patients in the incubation period.…”

Section: Infectivity and Transmission Risk Of Asymptomatic Carriersmentioning

confidence: 99%

Clinical characteristics and infectivity of asymptomatic carriers of SARS‑CoV‑2 (Review)

Zhang

Zhou

et al. 2020

Exp Ther Med

View full text Add to dashboard Cite

Since December 2019, the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. At present, confirmed patients are the main source of infection, while a number of studies have indicated that asymptomatic carriers also have the ability to spread the virus. As of September 29, 2020, as the first country to report coronavirus disease 2019 (COVID-19), China has 375 asymptomatic infections according to the National Health Commission of China. Asymptomatic carriers have become the current focus of global epidemic prevention and control efforts. The present review article provides a brief introduction on the clinical characteristics and infectivity of asymptomatic carriers, and makes suggestions for the identification of asymptomatic carriers. Contents

show abstract

Comparison of transmissibility of coronavirus between symptomatic and asymptomatic patients: Reanalysis of the Ningbo Covid-19 data

Cited by 20 publications

References 5 publications

Chest CT findings in asymptomatic cases with COVID-19: a systematic review and meta-analysis

Chest CT findings in asymptomatic cases with COVID-19: a systematic review and meta-analysis

Asymptomatic SARS-CoV-2 infections: What do we need to know?

Clinical characteristics and infectivity of asymptomatic carriers of SARS‑CoV‑2 (Review)

Contact Info

Product

Resources

About