Comparison of Translocation Rates of Various Indigenous Bacteria from the Gastrointestinal Tract to the Mesenteric Lymph Node

Steffen, E K; Berg, Rodney D.; Deitch, Edwin A.

doi:10.1093/infdis/157.5.1032

Cited by 224 publications

(122 citation statements)

References 30 publications

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…The rate of translocation to the liver, spleen, and mesenteric lymph nodes was 100% in both groups at both time points. Although it has been reported that anaerobic bacteria have a lower tendency to translocate, 24 we found, in this experiment, that anaerobic bacteria translocated at the same rate as aerobic bacteria. Under normal conditions a series of protective mechanisms contribute to prevent bacterial translocation except in one rat out of six (16%).…”

Section: Histological Studycontrasting

confidence: 76%

“…Blood samples were expressed per milliliter of blood. ''Total anaerobic plate group were subjected to portal pressure measurement at 24 and 48 hours (6 at each time). A venous catheter (outside count'' was performed by placing the samples on BHI and incubating under anaerobic condition (Gas Pack system, Gas diameter 0.25 mm) was passed through a peripheral branch of the superior mesenteric vein and was advanced to the porPack; Becton Dickinson Microbiology Systems, MD) at 37ЊC for 3 days.…”

Section: Measurement Of Portal Pressurementioning

confidence: 99%

“…After sedimentation of blood cells by cen-according to Kubes,20 24 hours after induction of insult. Animals were placed on heating blankets, anesthetized by ether, trifugation (1000g, 10 minutes) serum bilirubin, alkaline phosphatase, serum aspartate transaminase (AST) and ala-and after injection of 1000 U of heparin, both renal pedicles m4533f0014…”

Section: Liver Enzymesmentioning

confidence: 99%

See 2 more Smart Citations

Bacterial translocation in acute liver injury induced byD- galactosamine

Kasravi

Wang

et al. 1996

Hepatology

View full text Add to dashboard Cite

Acute liver injury and hepatic failure are serious Acute liver injury is associated with a high rate of infectious and septic complications. Most of these infec-clinical conditions that are sometimes observed in extions are produced by gram negative enteric bacteria. tensive hepatic surgery and in patients with multiple We evaluated bacterial translocation, intestinal perme-system organ failure. 1,2 Bacterial infection and sepsis ability, blood flow, portal pressure, and intestinal mi-are recognized as dangerous complications of this remcroflora after induction of liver injury and 70% liver re-edy with significant share in its morbidity and mortalsection in the rat. The rate of translocation to both portal ity. [3][4][5] Gram-negative enteric bacteria are frequent and arterial blood was 100% at 24 hours and 50% at 48 causative organisms in most of the published studies. 6-8 hours after liver resection compared with 83% to portal It has been shown that the gut, as a reservoir of enteric vein and 50% to aortic blood at both time points after bacteria in the body, plays an important role in many acute liver injury. Translocation to intraabdominal orcritical clinical situations, such as major burns, hemorgans (liver, spleen, and mesenteric lymph nodes) was rhagic shock, and so on. 9 Under normal conditions a 100% in both groups at both 24 and 48 hours. The rate series of protective measures, such as mucosal barrier of translocation increased after liver injury at 48 hours with progression of the liver injury but was decreased function, immunoglobulin secretion, and local and sysin the 70% liver resection group with improvement of temic macrophage system prevent translocation of liver function. ''Total aerobic'' and ''total anaerobic'' bac-these potential pathogens to the extraintestinal sites. 10 terial counts in small intestine and cecum were not af-Severe clinical disorders may disrupt these normal profected. Pulmonary, distal small intestine, and cecal tective mechanisms and make it possible for the intestiblood flow were decreased in both groups, whereas nal bacteria to translocate. Translocation of endotoxin blood flow in the proximal small intestine was unaf-and intestinal bacteria in acute liver injury may intenfected. Portal pressure and flow were increased after sify the extent of injury and may also be responsible 70% liver resection, but they were decreased in acute for the high rate of associated infection and sepsis obliver injury. After acute liver injury, permeability of both served in these patients. So far, little attention has MATERIALS AND METHODSgery, Lund University, 221 85 Lund, Sweden. Experimental Groups.One hundred eight Sprague-

show abstract

Section: Histological Studycontrasting

confidence: 76%

Section: Measurement Of Portal Pressurementioning

confidence: 99%

Section: Liver Enzymesmentioning

confidence: 99%

See 1 more Smart Citation

Bacterial translocation in acute liver injury induced byD- galactosamine

Kasravi

Wang

et al. 1996

Hepatology

View full text Add to dashboard Cite

show abstract

“…Organisms of group Enterobacteriaceae continues to be a major cause of Gram negative aerobic bacillary bacteraemia. This increase in invasion by Gram negative bacilli is perhaps because the organisms translocate more efficiently from the gastro-intestinal tract than do other bacteria 5,6 . ICU associated infections are mostly due to Staphylococcus aureus & Coagulase negative Staphylococcus epidermidis arising from contaminated intra-vascular devices like artificial heart valves, intravenous and intraarterial catheters 7 .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Septicaemia and Antibiogram of Different Etiological Agents in Patients of Intensive Care Units of a Tertiary Care Centre in Northern India

Mishra¹,

Verma²,

Joshi³

et al. 2013

Nepal J Epidemiology

View full text Add to dashboard Cite

show abstract

“…First, translocation of bacteria to mesenteric lymph nodes and the portal circulation may result in systemic bacteremia with subsequent peritoneal seeding, resulting in peritonitis. It has been shown that gram-negative aerobic enteric bacteria translocate more efficiently from the gastro-intestinal tract than other bacteria, especially obligate anaerobes [11,12]. It could be possible that colonoscopy predisposes to bacterial translocation and subsequent hematogenic peritonitis.…”

mentioning

confidence: 99%