Comparison of transepidermal water loss (TEWL) measurements with two novel sensors based on different sensing principles

Mundlein, M.; Valentin, B.; Chabicovsky, R.; Nicolics, J.; Weremczuk, Jerzy; Tarapata, Grzegorz; Jachowicz, Ryszard

doi:10.1016/j.sna.2007.04.012

Cited by 14 publications

(13 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, this assessment can be useful for evaluating the properties of cosmetics and topical medications such as irritancy, and their potential effects on skin hydration, skin repair or protection against UV damage. 3,4 Measuring the transepidermal water loss (TEWL) as a measure of skin barrier function is considered a very useful, noninvasive method, [5][6][7][8][9] although Chilcott et al showed in an in vitro system that barrier function and TEWL were not directly correlated. 10 Despite this, TEWL measurements are still considered a valuable tool for assessing barrier function in clinical studies.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a hand-held evaporimeter (VapoMeter^®) for the measurement of transepidermal water loss in healthy dogs

Lau-Gillard

Hill

Chesney

et al. 2010

Veterinary Dermatology

View full text Add to dashboard Cite

In humans, transepidermal water loss (TEWL) is measured by noninvasive techniques using either open- or closed-chamber instruments. The aim of this study was to investigate the use of a hand-held, closed chamber device (Vapometer) to measure TEWL in canine skin. Repeated measurements obtained from multiple body sites in one short and one long-coated dog had mean coefficients of variation ranging from 20% to 33%. In the short-coated dog, TEWL ranged from a mean of 5.8 g/m(2)/h on the ventral abdomen to 24.4 g/m(2)/h between the shoulders. In the long-coated dog, mean TEWL values ranged from 26.3 g/m(2)/h on the right chest wall to 51.3 g/m(2)/h in the right axilla. TEWL readings differed significantly at different body sites and showed significant day-to-day variation. In a comparison of a further 20 dogs, TEWL readings obtained from the lateral thorax differed significantly between dogs. Furthermore, in seven of the twenty dogs, readings differed significantly when one side was compared with the other. The Vapometer was able to measure TEWL in canine skin and yielded values similar to those previously reported in the literature using other devices. However, for use in clinical studies, the significant site to site, day-to-day and dog to dog variations would make changes induced by disease, drugs, dietary supplements or topical agents very difficult to reliably detect.

show abstract

Section: Introductionmentioning

confidence: 99%

Evaluation of a hand-held evaporimeter (VapoMeter^®) for the measurement of transepidermal water loss in healthy dogs

Lau-Gillard

Hill

Chesney

et al. 2010

Veterinary Dermatology

View full text Add to dashboard Cite

show abstract

“…In the last years, TEWL studies focused on the benefits of phytocompounds used in cosmetology [44] and of the anti-aging skin products [45]. In this research, the measurements with Tewameter®TM300 probe were accomplished following a procedure previously described in the literature [46]: the probe was recalibrated in the first day of the trial according to the manufacturer’s indications [47] while room humidity and temperature were continuously monitored and kept in a narrow range of values.…”

Section: Methodsmentioning

confidence: 99%

Influence of emulsifiers on the characteristics of polyurethane structures used as drug carrier

Heghes

Şoica

Ardelean

et al. 2013

Chemistry Central Journal

View full text Add to dashboard Cite

BackgroundEmulsifiers have a significant role in the emulsion polymerization by reducing the interfacial tension thus increasing the stability of colloidal dispersions of polymer nanostructures. This study evaluates the impact of four emulsifiers on the characteristics of polyurethane hollow structures used as drug delivery system.ResultsPolyurethane (PU) structures with high stability and sizes ranging from nano- to micro-scale were obtained by interfacial polyaddition combined with spontaneous emulsification. The pH of PU aqueous solutions (0.1% w/w) was slightly acidic, which is acceptable for products intended to be used on human skin. Agglomerated structures with irregular shapes were observed by scanning electron microscopy. The synthesized structures have melting points between 245-265°C and reveal promising results in different evaluations (TEWL, mexametry) on murine skin.ConclusionsIn this study hollow PU structures of reduced noxiousness were synthesized, their size and stability being influenced by emulsifiers. Such structures could be used in the pharmaceutical field as future drug delivery systems.

show abstract

“…Efficacy was assessed in terms of membrane integrity, infiltration of inflammatory mediators, serum IgE levels, as well as symptomatic improvement. Transepidermal water loss (TEWL) is a parameter for determining the moisture barrier function of skin as well as assessing the nature of skin suffering from eczema because it arises when the skin barrier is disrupted (16). Apart from TEWL, erythema (skin redness) is also an essential clinical parameter in eczematous skin lesions (2).…”

Section: Transepidermal Water Loss Erythema and Skin Lesionsmentioning

confidence: 99%

Topical Lyogel Containing Corticosteroid Decreases IgE Expression and Enhances the Therapeutic Efficacy Against Atopic Eczema

Anuwi

Tengku-Ahmad

2014

AAPS PharmSciTech

View full text Add to dashboard Cite

Hydrocortisone cream intended for atopic eczema often produces unwanted side effects after long-term use. These side effects are essentially due to repeated percutaneous administration of the medication for skin dermatitis, as atopic eczema is a relapsing disorder. Hence, there is a need to develop a new hydrocortisone formulation that will deliver the drug more effectively and require a reduced dosing frequency; therefore, the side effects could be minimized. In this study, a hydroxypropyl methylcellulose (HPMC) lyogel system based on 80% organic and 20% aqueous solvents containing 1% hydrocortisone was formulated. The hydrocortisone lyogel physicochemical characteristics, rheological properties, stability profile, and in vitro Franz cell drug release properties, as well as the in vivo therapeutic efficacies and dermal irritancy in Balb/c mice were investigated. The HPMC lyogel appeared clear and soft and was easy to rub on the skin. The lyogel also showed a higher drug release profile compared with commercial hydrocortisone cream. Similar to the cream, HPMC lyogels exhibited pseudoplastic behavior. From the mouse model, the hydrocortisone lyogel showed higher inflammatory suppressive effects than the cream. However, it did not reduce the transepidermal water loss as effectively as the control did. The dermal irritancy testing revealed that the hydrocortisone lyogel caused minimal irritation. In conclusion, HPMC lyogel is a promising vehicle to deliver hydrocortisone topically, as it showed a higher drug release in vitro as well as enhanced therapeutic efficacy in resolving eczematous inflammatory reaction compared with commercial cream.

show abstract

Comparison of transepidermal water loss (TEWL) measurements with two novel sensors based on different sensing principles

Cited by 14 publications

References 5 publications

Evaluation of a hand-held evaporimeter (VapoMeter^®) for the measurement of transepidermal water loss in healthy dogs

Evaluation of a hand-held evaporimeter (VapoMeter^®) for the measurement of transepidermal water loss in healthy dogs

Influence of emulsifiers on the characteristics of polyurethane structures used as drug carrier

Topical Lyogel Containing Corticosteroid Decreases IgE Expression and Enhances the Therapeutic Efficacy Against Atopic Eczema

Contact Info

Product

Resources

About

Comparison of transepidermal water loss (TEWL) measurements with two novel sensors based on different sensing principles

Cited by 14 publications

References 5 publications

Evaluation of a hand-held evaporimeter (VapoMeter®) for the measurement of transepidermal water loss in healthy dogs

Evaluation of a hand-held evaporimeter (VapoMeter®) for the measurement of transepidermal water loss in healthy dogs

Influence of emulsifiers on the characteristics of polyurethane structures used as drug carrier

Topical Lyogel Containing Corticosteroid Decreases IgE Expression and Enhances the Therapeutic Efficacy Against Atopic Eczema

Contact Info

Product

Resources

About

Evaluation of a hand-held evaporimeter (VapoMeter^®) for the measurement of transepidermal water loss in healthy dogs

Evaluation of a hand-held evaporimeter (VapoMeter^®) for the measurement of transepidermal water loss in healthy dogs