“…In diagnosing hypocapnia, the ETPCO 2 cutoff 30 mmHg is accepted by some authors while a 25 mmHg cutoff is preferred by others. 9,13,24,25 The inconsistency in defining hypocapnia stems from the observations that the clinical consequences of HV are not dependent only on CO 2 levels, but also on the competence of the alkaline buffering systems, neuronal reactivity, integrity of the Ca 2 þ /Mg 2 þ balance in smooth muscle, and the efficacy of habituation. 40 Furthermore, symptoms that are typically associated with HV such as paresthesias of fingers or face, lightheadedness, dizziness, palpitations, tachycardia, headache, fatigue, heaviness of arms or legs, tremor of hands, hot or cold sensations, chest pain, nausea, tinnitus, visual blurring are not specific for hypocapnia and may be encountered in a variety of other disease states.…”