Comparison of total serum immunoglobulin E and absolute eosinophil count levels among asthmatic and non-asthmatic children

Chaudhary, Gyanendra; Kumar, Anil; Shashtri, Madhurmay; Chaudhary, Vidya

doi:10.32677/ijch.2017.v04.i03.016

Cited by 8 publications

(14 citation statements)

References 8 publications

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“…In the present study, male to female ratio was 1.4: 1, which was similar to the study done by Uyan et al in which asthma was found to be significantly higher in boys than in girls (1.4:1). 7 In the present study, urban predominance was seen which was in accordance with the study by Srinivasa et al and Chaudhary et al 8,9 The present study observed 45.67 % of the cases with a family history of asthma similarly Stephanie J et al observed greater associations between childhood asthma and family history of asthma. 10 We found allergic rhinitis was common comorbid condition seen in asthmatic children as was observed by studies done by Bisaccioni et al and Sanja Dimitrijevic et al 11,12 In present study, 59% children belonged to low socioeconomic class, 31% children were from middle socio-economic class and 10% were from upper socioeconomic class.…”

Section: Discussionsupporting

confidence: 92%

“…16,17 The present study also revealed increased mean serum IgE levels (range: 247-1747 IU/ml) and correlated well with severity of asthma. These finding were consistent with studies done by Ching et al, Chandran et al and Chaudhary et al 18,19,9 In Thirunavukkarasu Sandeep et al study mean IgE levels ranged from 151.95 IU/ml in normal subjects to 1045.32 IU/ml in severe asthmatics and they also observed that IgE levels were increased as the severity of asthma was increased. 20 Limitations of present study were small population and it is not a case control study as the serum IgE level was an invasive, costly and time-consuming test.…”

Section: Discussionsupporting

confidence: 90%

“…13,14,15 In Chaudhary et al study the mean AEC was significantly higher in asthma cases (746.63±492.02 cells/mm3) as compared to healthy children (220.23±121.69 cells/mm3) as was observed in the present study. 9 In bronchial asthma, IgE is thought to play an important role in the development of bronchial hyperresponsiveness. 16,17 The present study also revealed increased mean serum IgE levels (range: 247-1747 IU/ml) and correlated well with severity of asthma.…”

Section: Discussionmentioning

confidence: 99%

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A study on correlation of serum IgE levels with diagnosis and severity of asthma in children

Snehalatha¹,

Begum²,

Raju³

2018

Int J Contemp Pediatr

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Background: Asthma is a chronic inflammatory airway disorder which increases bronchial hyperreactivity to various allergens and irritants characterized by narrowing of airways. Immunoglobulin E (Ig E) plays major role in the pathogenesis of asthma which is produced due to dysregulation of type 2 T helper lymphocytes (Th2) induced cytokines in genetically susceptible individual after exposing to allergens or irritants. The aim of this study was to estimate serum Ig E level in children between 3-12 years of age and to correlate it with the clinical diagnosis and severity of asthma.Methods: A prospective interventional study was done over a period of one year, enrolling 81 children aged between 3-12 years, who were newly diagnosed cases of asthma attending asthma clinic in a tertiary care pediatric government hospital. Serum IgE level was estimated and its correlation with the severity of asthma was assessed.Results: The mean Absolute Eosinophil Count (AEC) of the study was 305.85±188.40 cells /mm3. Mean Ig E level was increased in asthmatic children (874.59±287 IU/ml). Mean serum Ig E level in mild intermittent asthma was 247.92 ± 89.50 IU/ml, in mild persistent asthma was 742.95±306.78 IU/ml, in moderate persistent asthma was 1142±196.88 IU/ml and in severe persistent asthma was 1790±121.50 IU/ml. The increasing level of serum Ig E was found to be statistically significant (p <0.05) with increasing grading of asthma.Conclusions: Elevated serum IgE levels support clinical diagnosis of asthma in children and can predict severity of asthma and can be used to counsel parents for better compliance in the management of bronchial asthma.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A study on correlation of serum IgE levels with diagnosis and severity of asthma in children

Snehalatha¹,

Begum²,

Raju³

2018

Int J Contemp Pediatr

View full text Add to dashboard Cite

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“…It has been noted that the mean serum tIgE levels in children with asthma was significantly higher than those in normal controls (p value <0.001). [16][17][18][19] In this study serum tIgE levels were above the normal limit for age in 86.2% patients with asthma. Chandran et al, Chaudhary et al, and Lama et al, found raised serum tIgE levels in 75% ,71.4% and 63.3% of asthmatic children respectively.…”

Section: Discussionmentioning

confidence: 86%

“…Chandran et al, Chaudhary et al, and Lama et al, found raised serum tIgE levels in 75% ,71.4% and 63.3% of asthmatic children respectively. 11,16,18 There is a strong relationship between increased serum tIgE levels and asthma prevalence. 20 Authors noted an increase in the levels of serum tIgE as the severity of asthma increased and this was statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Serum immunoglobulin E and absolute eosinophil count as markers of severity in childhood asthma

Trivedi¹,

Patel²

2020

Int J Contemp Pediatr

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Background: Asthma is a chronic inflammatory condition of the airways resulting in increased airway reactivity to a variety of stimuli like allergens, irritants, viruses and exercise. There is a strong association between the exposure of allergens and development of asthmatic symptoms. A hypersensitivity reaction initiated by immunologic mechanisms mediated by Immunoglobulin E (IgE) antibodies occurs in allergic asthma. IgE and eosinophils play an important role in the inflammatory process resulting in bronchial hyperresponsiveness. The aim of this study was to evaluate serum total IgE levels and Absolute Eosinophil Count (AEC) as markers of disease activity and study their association with the severity of bronchial asthma in children.Methods: A prospective study was conducted in the paediatric department of a tertiary care hospital in Ahmedabad, Gujarat, India from July 2017 to December 2018. Children between 4-14 years of age diagnosed as having bronchial asthma were included in the study. Serum total IgE levels and absolute eosinophil count were done in all the study participants and their correlation with the severity of asthma was assessed.Results: Of the total 109 patients of asthma, 44(40.4%) had intermittent asthma, 30(27.5%) mild persistent, 25(22.9%) moderate persistent and 10(9.2%) severe persistent asthma. Serum total IgE levels were raised above the normal limits for age in 94(86.2%) patients and increased AEC was found in 61(56 %) patients. Both serum total IgE levels and AEC increased significantly (p<0.0001) with increasing severity of asthma.Conclusions: Serum total IgE levels and AEC can be used to predict the severity of asthma in children.

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Autophagy‐related 5 gene mRNA expression and ATG5 rs510432 polymorphism in children with bronchial asthma

Ahmad

Diab

Behiry

et al. 2022

Pediatric Pulmonology

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Purpose: Bronchial asthma is a common chronic respiratory disease in children with complex pathogenesis, characterized by airway hyper-responsiveness, obstruction, mucus hyperproduction, and airway remodeling. Autophagy is important for cellular physiology, and the ATG5 rs510432 has recently been implicated in several fundamental characteristics of childhood asthma pathogenesis and may play a role in the disease progression. This study aims to assess the expression of ATG5 messenger RNA (mRNA) according to rs510432 polymorphism in asthmatic children and to evaluate their possible relation with the development of the disease.Methods: ATG5 mRNA expression and rs510432 polymorphism were measured using real-time polymerase chain reaction in 57 asthmatic children patients and 46 healthy controls.Results: ATG5 level was significantly higher in asthmatic children than in controls and a significant increase in the frequency of TT and CC genotype of ATG5 rs510432 gene polymorphism was found in asthmatic patients when compared to control subjects (p < 0.001; and p = 0.01, respectively), and there was a statistically significant decrease in the frequency of CT genotype of ATG5 rs510432 gene polymorphism in asthmatic patients when compared to control subjects (p < 0.001).Conclusion: ATG5 rs510432 gene polymorphism plays an important role in childhood asthma pathogenesis.

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Comparison of total serum immunoglobulin E and absolute eosinophil count levels among asthmatic and non-asthmatic children

Cited by 8 publications

References 8 publications

A study on correlation of serum IgE levels with diagnosis and severity of asthma in children

A study on correlation of serum IgE levels with diagnosis and severity of asthma in children

Serum immunoglobulin E and absolute eosinophil count as markers of severity in childhood asthma

Autophagy‐related 5 gene mRNA expression and ATG5 rs510432 polymorphism in children with bronchial asthma

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