Comparison of topical tramadol and ketamine in pain treatment after tonsillectomy

Tekelioğlu, Ümit Yaşar; Apuhan, Tayfun; Akkaya, Akçan; Demırhan, Abdullah; Yıldız, İsa; Şimşek, Tuğçe; Gök, Üzeyir; Koçoğlu, Hasan

doi:10.1111/pan.12148

Cited by 37 publications

(29 citation statements)

References 14 publications

(22 reference statements)

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“…Javid and colleagues [70] demonstrated that both subcutaneous and intravenous injections of ketamine at the end of surgery were safe and effective for post-tonsillectomy pain control without increasing the risk of complications. Two separate studies found the topical application of tramadol and ketamine to be a safe, effective, and easy analgesic approach for decreasing post-tonsillectomy pain [71,72] . Nielsen [73] suggested that a sufentanil and ketamine nasal spray provides a rapid onset of analgesia for a variety of painful procedures with few adverse effects and has promising features for use in pediatric procedural pain management.…”

Section: Pediatric Usementioning

confidence: 99%

Ketamine use in current clinical practice

2016

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After nearly half a century on the market, ketamine still occupies a unique corner in the medical armamentarium of anesthesiologists or clinicians treating pain. Over the last two decades, much research has been conducted highlighting the drug's mechanisms of action, specifically those of its enantiomers. Nowadays, ketamine is also being utilized for pediatric pain control in emergency department, with its anti-hyperalgesic and anti-inflammatory effects being revealed in acute and chronic pain management. Recently, new insights have been gained on ketamine's potential anti-depressive and antisuicidal effects. This article provides an overview of the drug's pharmacokinetics and pharmacodynamics while also discussing the potential benefits and risks of ketamine administration in various clinical settings.

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Section: Pediatric Usementioning

confidence: 99%

Ketamine use in current clinical practice

2016

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“…Other studies used ketamine topically after tonsillectomy; the treatment produced an analgesic effect and decreased the need for rescue medication. [14][15][16] Satilmiş et al 12 investigated the efficacy of adding ketamine to local anesthetic agents to increase the duration of regional anesthesia and postoperative analgesia during surgical extraction of third molars. They concluded that the combination of a local anesthetic and sub-anesthetic doses of ketamine can produce good local anesthesia.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Effects of Topical Ketamine and Tramadol on Postoperative Pain After Mandibular Molar Extraction

Gönül

Satilmis

Çiftçi

et al. 2015

Journal of Oral and Maxillofacial Surgery

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“…Outcomes analyzed were postoperative pain (pain scores after leaving the operation room) [2]–[5], [8]–[23], postoperative (24 hours) analgesic requirements (either doses or percentage of patient receiving postoperative opioids or nonopioids analgesics)[2]–[4], [8]–[10], [12]–[14], [16], [19], [20], [22]–[25], time to first analgesic administration (opioid or nonopioid analgesics administered with a defined pain intensity target)[3]–[5], [8]–[10], [12]–[14], [18], [22], [23], [26], time to first oral uptake [2], [5], [13], [14], postoperative nausea and vomiting (percentage of patients or dose of antiemetics) [2], [8], [9], [12]–[18], [24], [25] and the occurrence of psycho-mimetic manifestations including nightmares [9], [10], [18], sleep pattern change (percentage of patients) [9], [10], [12], [19], hallucinations (percentage of patients) [5], [8], [18], [19], [25] or sedation (sedation scores) [4], [5], [8], [9], [11], [15], [17], [24]. These outcomes were compared with preoperative ketamine ...…”

Section: Methodsmentioning

confidence: 99%

Efficacy of Ketamine in Improving Pain after Tonsillectomy in Children: Meta-Analysis

et al. 2014

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Background and objectivesThe goal of this meta-analysis study was to perform a systematic review of the literature on the effects of ketamine on postoperative pain following tonsillectomy and adverse effects in children.Subjects and MethodsTwo authors independently searched three databases (MEDLINE, SCOPUS, Cochrane) from their inception of article collection to February 2014. Studies that compared preoperative ketamine administration (ketamine groups) with no treatment (control group) or opioid administration (opioid group) where the outcomes of interest were postoperative pain intensity, rescue analgesic consumption, or adverse effects (sedation, nausea and vomiting, bad dream, worsening sleep pattern, and hallucination) 0–24 hours after leaving the operation room were included in the analysis.ResultsThe pain score reported by the physician during first 4 hours and need for analgesics during 24 hours postoperatively was significantly decreased in the ketamine group versus control group and was similar with the opioid group. In addition, there was no significant difference between ketamine and control groups for adverse effects during 24 hours postoperatively. In the subgroup analyses (systemic and local administration) regarding pain related measurements, peritonsillar infiltration of ketamine was more effective in reducing the postoperative pain severity and need for analgesics.ConclusionPreoperative administration of ketamine systemically or locally could provide pain relief without side-effects in children undergoing tonsillectomy. However, considering the insufficient evaluation of efficacy of ketamine according to the administration methods and high heterogeneity in some parameters, further clinical trials with robust research methodology should be conducted to confirm the results of this study.

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Comparison of topical tramadol and ketamine in pain treatment after tonsillectomy

Abstract: Topical tramadol and ketamine seem to be safe, effective, and easy analgesic approach for decreasing tonsillectomy pain.

Cited by 37 publications

References 14 publications

Ketamine use in current clinical practice

Ketamine use in current clinical practice

Comparison of the Effects of Topical Ketamine and Tramadol on Postoperative Pain After Mandibular Molar Extraction

Efficacy of Ketamine in Improving Pain after Tonsillectomy in Children: Meta-Analysis

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