Comparison of topical capsaicin and topical piroxicam in the treatment of acute trauma-induced pain: A randomized double-blind trial

Koçak, Abdullah Osman; Doğruyol, Sinem; Akbaş, İlker; Menekşe, Tuğba Sanalp; Gür, Sultan Tuna Akgöl; Koçak, Meryem Betos; Çekmen, Bora; Örün, Serhat; Çakır, Zeynep

doi:10.1016/j.ajem.2020.05.104

Cited by 5 publications

(5 citation statements)

References 14 publications

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“…A Cochrane systematic review on topical NSAIDs for acute musculoskeletal pain published in 2015 was included [ 15 ]. This review was updated with an additional 18 studies: 11 compared to placebo [ 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 ], one compared to oral NSAIDs [ 60 ], three compared to topical NSAIDs [ 61 , 62 , 63 ], and three compared to other topical drugs [ 64 , 65 , 66 ].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Multidisciplinary Guidelines for the Rational Use of Topical Non-Steroidal Anti-Inflammatory Drugs for Musculoskeletal Pain (2022)

Shi

Shao

et al. 2023

JCM

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(1) Background: Topical non-steroidal anti-inflammatory drugs (NSAIDs) are one of the primary drugs for treating musculoskeletal pain. However, there are currently no evidence-based recommendations about drug selection, drug administration, drug interactions, and use in special populations or other pharmacology-related content of such medications. To this end, the Chinese Pharmaceutical Association Hospital Pharmacy Professional Committee developed multidisciplinary guidelines on using topical NSAIDs to treat musculoskeletal pain. (2) Methods: The guidelines development process followed the World Health Organization guideline development handbook, the GRADE methodology, and the statement of Reporting Items for Practice Guidelines in Healthcare. The guideline panel used the Delphi method to identify six clinical questions to be addressed in the guidelines. An independent systematic review team conducted a systematic search and integration of evidence. (3) Results: Based on the balance between the benefits and harms of an intervention, the quality of the evidence, patient preferences and values, and resource utilization, the guideline panel developed 11 recommendations and nine expert consensuses on using topical NSAIDs to treat acute and chronic musculoskeletal pain. (4) Conclusions: Based on the effectiveness and overall safety of topical NSAIDs, we recommend patients with musculoskeletal pain use topical NSAIDs and suggest high-risk patients use topical NSAIDs, such as those with other diseases or receiving other concurrent treatments. The evidenced-based guidelines on topical NSAIDs for musculoskeletal pain incorporated a pharmacist perspective. The guidelines have the potential to facilitate the rational use of topical NSAIDs. The guideline panel will monitor the relevant evidence and update the recommendations accordingly.

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Section: Resultsmentioning

confidence: 99%

“…Four RCTs compared topical NSAIDs and other topical medications for acute musculoskeletal pain [ 64 , 65 , 66 , 69 ]. Due to the significant comparison heterogeneity among the included studies, data synthesis could not be performed.…”

Section: Resultsmentioning

confidence: 99%

Multidisciplinary Guidelines for the Rational Use of Topical Non-Steroidal Anti-Inflammatory Drugs for Musculoskeletal Pain (2022)

Shi

Shao

et al. 2023

JCM

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“…This difference was most pronounced at 72 hours, with a mean difference of delta VAS scores of 1.53 (95% CI, 0.85-2.221) and a mean percentage of the reduction in VAS scores of 19.7% (95% CI, 12.4%-27.2%) (P < .001). 1 Reported adverse effects, such as burning, itching, and rash, were mild and infrequent and showed no significant difference between the treatment groups.…”

Section: Topical Capsaicin Is An Effective Alternative To a Topical N...mentioning

confidence: 89%

Time to consider topical capsaicin for acute trauma pain?

Cleary¹

2022

The Journal of Family Practice

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Topical capsaicin is more effective than topical piroxicam at reducing pain in acute upper extremity injuries. PRACTICE CHANGERUse topical capsaicin gel 0.05% for pain reduction in patients with isolated blunt injuries of the upper extremity without fracture. STRENGTH OF RECOMMENDATIONB: Based on a single randomized controlled trial (RCT) 1 Kocak AO, Dogruyol S, Akbas I, et al. Comparison of topical capsaicin and topical piroxicam in the treatment of acute trauma-induced pain: a randomized double-blind trial.

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“…On another aspect, repeated administration of capsaicin was proved by numerous researchers to inhibit the production and/or action of substance P [38,282,[303][304][305][306][307][308][309] at least when locally applied. This is important, because apart from the other actions of substance P [310][311][312][313], it is implicated in the negative effects of infection-associated inflammation in animal models [314,315] and in teeth [316]; a recent review, also examined the association between the defensive capacity of the respiratory system and substance P in the context of the COVID-19 infection [317].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Properties of Capsaicin: Available Data and Future Research Perspectives

Periferakis,

Periferakis

et al. 2023

Nutrients

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Capsaicin is a phytochemical derived from plants of the genus Capsicum and subject of intensive phytochemical research due to its numerous physiological and therapeutical effects, including its important antimicrobial properties. Depending on the concentration and the strain of the bacterium, capsaicin can exert either bacteriostatic or even bactericidal effects against a wide range of both Gram-positive and Gram-negative bacteria, while in certain cases it can reduce their pathogenicity by a variety of mechanisms such as mitigating the release of toxins or inhibiting biofilm formation. Likewise, capsaicin has been shown to be effective against fungal pathogens, particularly Candida spp., where it once again interferes with biofilm formation. The parasites Toxoplasma gondi and Trypanosoma cruzi have been found to be susceptible to the action of this compound too while there are also viruses whose invasiveness is significantly dampened by it. Among the most encouraging findings are the prospects for future development, especially using new formulations and drug delivery mechanisms. Finally, the influence of capsaicin in somatostatin and substance P secretion and action, offers an interesting array of possibilities given that these physiologically secreted compounds modulate inflammation and immune response to a significant extent.

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Comparison of topical capsaicin and topical piroxicam in the treatment of acute trauma-induced pain: A randomized double-blind trial

Cited by 5 publications

References 14 publications

Multidisciplinary Guidelines for the Rational Use of Topical Non-Steroidal Anti-Inflammatory Drugs for Musculoskeletal Pain (2022)

Multidisciplinary Guidelines for the Rational Use of Topical Non-Steroidal Anti-Inflammatory Drugs for Musculoskeletal Pain (2022)

Time to consider topical capsaicin for acute trauma pain?

Antimicrobial Properties of Capsaicin: Available Data and Future Research Perspectives

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