Comparison of Thyroid Hormones in Euthyroid Athyreotic Patients Treated with Levothyroxine and Euthyroid Healthy Subjects

Jeon, Min Ji; Lee, Suk Hyun; Lee, Dong Kun; Han, Min-Gu; Kim, Hong‐Kyu; Kim, Won Gu; Kim, Tae Yong; Kim, Won; Shong, Young Kee; Ryu, Jin-Sook

doi:10.11106/ijt.2019.12.1.28

Cited by 2 publications

(1 citation statement)

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“…Serum TSH levels were measured using the TSH-CTK-3a radioimmunoassay (DiaSorin SpA, Saluggia, Italy) with a functional sensitivity of 0.07 mU/L. Serum fT4 levels were measured by radioimmunoassay (Immunotech, Prague, Czech Republic) with a functional sensitivity of 2.34 pmol/L [17,18]. The reference ranges of TSH and fT4 were 0.4-4.5 mIU/L and 0.80-1.90 mg/dL, respectively.…”

Section: Laboratory Measurementmentioning

confidence: 99%

Graves’ disease diagnosed in remnant thyroid after lobectomy for thyroid cancer

et al. 2022

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Background The coexistence of Graves’ disease with thyroid cancer is well-known and total thyroidectomy is recommended in such cases. However, Graves’ disease might be dormant at the time of surgery and diagnosed after lobectomy for thyroid cancer. Methods We assessed the incidence and clinicopathological characteristic of newly developed Graves’ disease after lobectomy for thyroid cancer between 2010 and 2019. Results In all, 11043 patients underwent lobectomy for thyroid cancer during the study period, and 26 (0.2%) were diagnosed with Graves’ disease during follow-up. The median age was 43.8 years, 88.5% were female, and all were euthyroid before surgery. The median time from lobectomy to the diagnosis of Graves’ disease was 3.3 years. Half of the patients were diagnosed based on thyroid function tests during routine follow-up, and others were diagnosed due to symptoms of thyrotoxicosis. Among patients who had checked preoperative thyroid autoantibodies, 61.1% showed positivity. Twenty-one (80.8%), and 2 (7.7%) patients received antithyroid drugs and radioactive iodine therapy, respectively, and 3 (11.5%) underwent completion thyroidectomy. Conclusion Although rare, Graves’ disease can occur in the remnant thyroid after lobectomy. Such patients are more likely to have autoantibodies. An appropriate workup is required when hyperthyroidism is found during the follow-up of patients after lobectomy.

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Section: Laboratory Measurementmentioning

confidence: 99%