Comparison of Thrombelastography (TEG) in Patients with Acute Cerebral Hemorrhage and Cerebral Infarction

Liu, Zongbao; Chai, Erqing; Chen, Hecheng; Huo, Hongzhi; Tian, Fei

doi:10.12659/msm.910121

Cited by 17 publications

(16 citation statements)

References 13 publications

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“…34,35 There was a statistically significant difference in TPI's comparison between the two groups in this study (P = .001). The TPI level was significantly higher than the reference range (6)(7)(8)(9)(10)(11)(12)(13)(14)(15) in both groups. The other performance of the TEG assay indicators proved that the infected patients had abnormal coagulation function.…”

Section: Discussionmentioning

confidence: 65%

“…Thromboelastography (TEG) is an effective method for the comprehensive in vitro assessment of coagulation in patients. 14 , 15 Today, TEG is often used for the dynamic monitoring of liver transplantation, 16 severe coagulation disorders, 17 including gastrointestinal hemorrhage, 18 massive postpartum bleeding, 19 severe emergency trauma, 20 bleeding from ruptured ectopic pregnancy, 21 and final coagulation in extracorporeal procedures. The method can be performed on whole blood specimens and provides an accurate and comprehensive picture of the patient’s coagulation status.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic Value of Thromboelastography (TEG) for the Diagnosis of Death in Infected Patients

Xuan

Wang

Wei

2021

Clin Appl Thromb Hemost

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In this study, we want to investigate the clinical value of each index of thromboelastography (TEG) on the prognosis of infected patients. The clinical baseline data and TEG test results of 431 infected patients in our hospital’s emergency department between January 2018 and December 2018 were selected. And the patients were divided into death and survival groups to analyze the predictive value of each index of TEG and the joint model on the death of infected patients. In the correlation study of C-reactive protein (CRP) and procalcitonin (PCT) with each TEG parameter, CRP was positively correlated with maximum amplitude (MA, r = 0.145, P = .003) and elasticity constants (E, r = 0.098, P = .043), respectively. PCT was positively correlated with coagulation reaction time (R, r = 0.124, P = .010) and time to MA (TMA) ( r = 0.165, P = .001), respectively; PCT was negatively correlated with α-Angle ( r = 0.124, P = .010) and coagulation index (CI, r = −0.108, P = .026), respectively. Multifactorial regression analysis showed that granulocytes, thrombocytes, platelet distribution width (PDW), and infection site were independent influences on infected patients’ death. Diagnostic data showed that all eight TEG indicators had good specificity for predicting death, but all had poor sensitivity; thrombodynamic potential index (TPI) had the best diagnostic value (area under the curve, AUC = 0.609, P = .002). The eight-indicator modeling of TEG showed that the TEG model combined with PCT and CRP, respectively, had lower diagnostic efficacy than PCT (AUC = 0.756, P < .001); however, TEG had better specificity (82.73%) when diagnosed independently. The granulocytes, thrombocytes, PDW, and infection site are independent influencing factors of death in infected patients. Each index of TEG has better specificity in the diagnosis of death in infected patients.

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Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of Thromboelastography (TEG) for the Diagnosis of Death in Infected Patients

Xuan

Wang

Wei

2021

Clin Appl Thromb Hemost

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“…The pathology of cerebral hemorrhage mainly comes from cerebral arteries such as the anterior cranial artery, the middle cranial artery, the posterior cranial artery, and the perforator artery in the brain stem. Under the pressure of the patient's own hypertension, some degenerative pathological changes have taken place in the arterial wall of the cranial artery, including the arterial middle membrane and arterial smooth muscle, which is finally manifested as the patient's sudden craniocerebral hemorrhage [ 4 , 5 ]. The method of dealing with primary injury can only control and not expand hematoma, but it cannot improve the nerve damage.…”

Section: Introductionmentioning

confidence: 99%

Effect of Minimally Invasive Puncture Drainage and Conservative Treatment on Prognosis of Patients with Cerebral Hemorrhage

Jia

Wang

Yang

et al. 2021

Journal of Healthcare Engineering

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The objective of this study was to explore the effect of minimally invasive puncture drainage under unsupervised learning algorithm and conservative treatment on the prognosis of patients with cerebral hemorrhage. Fifty patients with cerebral hemorrhage were selected as the research objects. The CT images of patients were segmented by unsupervised learning algorithm, and the application value of unsupervised learning algorithm on CT images of patients with cerebral hemorrhage was evaluated. According to the treatment wishes of the patients themselves and their authorizers, they were divided into 30 patients with cerebral hemorrhage in the minimally invasive group and 20 patients with cerebral hemorrhage in the conservative group. The incidence rate of complications of cerebral hemorrhage, the length of hospitalization of the two groups, hematoma volume at admission, 3 days and 7 days after operation, and the hematoma dissipation rate on the 3rd and 7th day after operation were used as the evaluation index of therapeutic effect. MRS and ADL scores were used as prognostic indicators. The results show that K-means clustering algorithm has high quality and short time for CT image segmentation. The overall incidence rate of complications in minimally invasive group was 10%, lower than that in conservative group (25%) ( P < 0.05 ), and the length of hospitalization in minimally invasive group was longer than that in conservative group ( P < 0.05 ). The hematoma volume of minimally invasive group was 16.5 ± 2.4 mL on the 3rd day after operation, and that of conservative group was 27.4 ± 1.8 mL. There was significant difference between the two groups ( P < 0.05 ). In addition, CT showed that the hematoma reduction degree of minimally invasive group was higher than that of conservative group, and the hematoma dissipation rate was higher than that of conservative group on the 3rd and 7th day ( P < 0.05 ). The good MRS score in minimally invasive group was 3.15 times that in conservative group, and the good ADL score was 1.6 times that in conservative group, and there was significant difference in the total score between the two groups ( P < 0.05 ). Minimally invasive puncture drainage is better than conservative treatment in the clearance of hematoma, which is conducive to the recovery of neurological function and daily life of patients with cerebral hemorrhage and is of great help to the prognosis of patients.

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“…Ureklin can inhibit vasoconstriction in patients and help patients to establish collateral circulation in the ischemic area of the brain. Relevant studies [3,4] have used ureklin in the treatment of patients with cerebrovascular disease and confirmed that it can effectively improve the neurological function and limb function of patients. However, the relevant mechanism of ureklin in the treatment of ACI is not yet fully understood.…”

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confidence: 99%

Observation of the Clinical Effect of Ureklin and Aspirin Combined with Rehabilitation Training in Patients with Acute Cerebral Infarction

Li¹

2021

IJPS

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Li et al.: Effect of Ureklin and Aspirin Combined with Rehabilitation TrainingTo observe the clinical effect of ureklin and aspirin combined with rehabilitation training in patients with acute cerebral infarction. A total of 120 patients with acute cerebral infarction admitted to our hospital from January 2018 to January 2021 were randomly divided into control group and observation group. Both groups received conventional treatment. On this basis, the control group was treated with aspirin combined with rehabilitation training and the observation group was treated with aspirin combined with rehabilitation training and ureklin. The clinical efficacy after 2 w of treatment and safety during treatment of the two groups were counted and the level of serum cytokine, hemorheology, neurological function and quality of life were compared between the two groups before and after 2 w of treatment. After 2 w of treatment, the total effective rate of control group was lower than that of observation group (p<0.05). After 2 w of treatment, level of serum vascular endothelial growth factor and scores of activity of daily living and Barthel index in both groups were higher than before treatment and there was statistical difference between observation group and control group (p<0.05). After 2 w of treatment, levels of serum homocysteine, cystatin-C, plasma viscosity, platelet aggregation rate, hematocrit, fibrin and score of National Institutes of Health Stroke Scale in both groups were lower than those before treatment and there was statistical difference between observation group and control group (p<0.05). During treatment, the total incidence of adverse reactions in the observation group was 6.67 % and there was no significant difference between the observation group and the control group (11.67 %, p>0.05). Ureklin and aspirin combined with rehabilitation training could effectively improve the synthesis of serum cytokines, hemorheology and neurological function in patients with acute cerebral infarction and improve the quality of life of patients, with better clinical efficacy.

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Comparison of Thrombelastography (TEG) in Patients with Acute Cerebral Hemorrhage and Cerebral Infarction

Cited by 17 publications

References 13 publications

Diagnostic Value of Thromboelastography (TEG) for the Diagnosis of Death in Infected Patients

Diagnostic Value of Thromboelastography (TEG) for the Diagnosis of Death in Infected Patients

Effect of Minimally Invasive Puncture Drainage and Conservative Treatment on Prognosis of Patients with Cerebral Hemorrhage

Observation of the Clinical Effect of Ureklin and Aspirin Combined with Rehabilitation Training in Patients with Acute Cerebral Infarction

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