Comparison of three-view thoracic radiography and computed tomography for detection of pulmonary nodules in dogs with neoplasia

Armbrust, Laura J.; Biller, David S.; Bamford, Aubrey; Chun, Ruthanne; Garrett, Laura D.; Sanderson, Michael W.

doi:10.2460/javma.240.9.1088

Cited by 89 publications

(73 citation statements)

References 25 publications

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“…The study was not meant to investigate the role of radiology and does not give details on radiological findings; it is mentioned here to give the reader an impression on distribution of tumor sizes. They may be missed by radiology, and it has been shown that computed tomography (CT) is more sensitive for their detection (Armbrust et al, 2012). Detectable tumors display as a mass of soft tissue opacity adjacent to the kidney, possibly with displacement of the kidney and other abdominal organs.…”

Section: Abdominal and Thoracic Radiographsmentioning

confidence: 99%

Pheochromocytoma and Multiple Endocrine Neoplasia

Reusch¹

2015

Canine and Feline Endocrinology

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Section: Abdominal and Thoracic Radiographsmentioning

confidence: 99%

Pheochromocytoma and Multiple Endocrine Neoplasia

Reusch¹

2015

Canine and Feline Endocrinology

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“…All bone metastases were confirmed cytologically through CT‐guided fine‐needle aspiration of the lesions showing bone lysis and adjunct soft‐tissue swelling on whole‐body CT. Metastasis to the lung was considered positive when one or more nodules were found in the pulmonary field area on CT. Soft‐tissue attenuating nodules more than 3 mm in diameter, as well as nodules that had a ground glass appearance or were poorly demarcated, were included …”

Section: Methodsmentioning

confidence: 99%

“…This modality could overcome the aforementioned limitations when staging urinary TCCs. It has been widely recognized that CT is more sensitive than thoracic radiography for detecting pulmonary nodules in dogs . More recently, CT has been shown to be superior to ultrasonography in detecting more nodes within the iliosacral lymphatic centre and in identifying iliosacral lymphadenomegaly .…”

Section: Introductionmentioning

confidence: 99%

Survival analysis in dogs with urinary transitional cell carcinoma that underwent whole‐body computed tomography at diagnosis

Iwasaki

Shimosato

Yoshikawa

et al. 2019

Vet Comparative Oncology

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This retrospective study aimed to evaluate factors associated with survival and to compare characteristics between tumour localizations in dogs with urinary transitional cell carcinoma (TCC) that underwent whole‐body computed tomography (CT) at diagnosis. Dogs with histologically confirmed TCC that received medical therapy between 2010 and 2017 were included; dogs that underwent surgery or radiotherapy for the primary tumour were excluded. According to the CT findings, primary tumour localization (classified into the Bladder, Urethra and Bladder and Urethra groups), prostate involvement, iliosacral lymphadenomegaly, sternal lymphadenomegaly and metastasis to the bone and lung were evaluated for survival analysis. CT at diagnosis revealed iliosacral lymphadenomegaly, sternal lymphadenomegaly, bone metastasis and lung metastasis in 47.7%, 18.5%, 24.6% and 35.4% of the 65 included dogs, respectively. The overall median survival time was 196 days. On multivariable analysis, TCC localization (hazard ratio [HR], 1.90; P = .037), bone metastasis (HR, 2.76; P = .013) and sternal lymphadenomegaly (HR, 3.56; P = .004) were significantly associated with survival. Compared to the Bladder group (n = 16), the Urethra group (n = 26) had higher metastasis rates to the bone (6.3% vs 42.3%; P = .045) and lung (6.3% vs 46.2%; P = .022). The survival time was shorter in the Urethra group than in the Bladder group (121.5 vs 420 days; P < .001), and it was similar only in female dogs (247 vs 420 days; P = .031). These findings suggest that whole‐body CT could be valuable for predicting the prognosis in urinary TCC.

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“…Although the recommended imaging modality will depend on the tumor type and location, in dogs it typically includes thoracic radiographs and/or abdominal ultrasound. While computed tomography (CT) and magnetic resonance imaging are readily available and routinely used in clinical veterinary medicine and positron emission tomography is becoming more accessible, they require general anesthesia in dogs and cost significantly more than these other modalities [71]. Another important aspect of veterinary medicine, particularly for comparative researchers evaluating novel cancer therapies in dogs, is that death in client-owned animals is frequently the result of euthanasia.…”

Section: Introductionmentioning

confidence: 99%

Canine cancer immunotherapy studies: linking mouse and human

Park¹,

Withers²,

Modiano³

et al. 2016

j. immunotherapy cancer

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Despite recent major clinical breakthroughs in human cancer immunotherapy including the use of checkpoint inhibitors and engineered T cells, important challenges remain, including determining the sub-populations of patients who will respond and who will experience at times significant toxicities. Although advances in cancer immunotherapy depend on preclinical testing, the majority of in-vivo testing currently relies on genetically identical inbred mouse models which, while offering critical insights regarding efficacy and mechanism of action, also vastly underrepresent the heterogeneity and complex interplay of human immune cells and cancers. Additionally, laboratory mice uncommonly develop spontaneous tumors, are housed under specific-pathogen free conditions which markedly impacts immune development, and incompletely model key aspects of the tumor/immune microenvironment. The canine model represents a powerful tool in cancer immunotherapy research as an important link between murine models and human clinical studies. Dogs represent an attractive outbred combination of companion animals that experience spontaneous cancer development in the setting of an intact immune system. This allows for study of complex immune interactions during the course of treatment while also directly addressing long-term efficacy and toxicity of cancer immunotherapies. However, immune dissection requires access to robust and validated immune assays and reagents as well as appropriate numbers for statistical evaluation. Canine studies will need further optimization of these important mechanistic tools for this model to fulfill its promise as a model for immunotherapy. This review aims to discuss the canine model in the context of existing preclinical cancer immunotherapy models to evaluate both its advantages and limitations, as well as highlighting its growth as a powerful tool in the burgeoning field of both human and veterinary immunotherapy.

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Comparison of three-view thoracic radiography and computed tomography for detection of pulmonary nodules in dogs with neoplasia

Abstract: CT was more sensitive than radiography for detection of pulmonary nodules. This was particularly evident in large-breed to giant-breed dogs. Thoracic CT is recommended in large-breed to giant-breed dogs with osteosarcoma if the detection of pulmonary nodules will change treatment.

Cited by 89 publications

References 25 publications

Pheochromocytoma and Multiple Endocrine Neoplasia

Pheochromocytoma and Multiple Endocrine Neoplasia

Survival analysis in dogs with urinary transitional cell carcinoma that underwent whole‐body computed tomography at diagnosis

Canine cancer immunotherapy studies: linking mouse and human

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