Comparison of three noninvasive methods for hemoglobin screening of blood donors

Abstract

Noninvasive Hb tests represent an attractive alternative by eliminating pain and reducing risks of blood contamination. The main problem for generating reliable results seems to be preanalytical variability in sampling. Despite the sensitivity to environmental stress, all methods are suitable for Hb measurement.

Assessment of a non-invasive haemoglobin sensor NBM 200 among pregnant women in rural India

“…Studies from Italy, Germany and France involved a fairly equal number of men and women reporting to blood donation centres, but anaemia prevalence is much lower in these countries compared to India. The German study reported a mean Hb value of 13.4 g/dL (SD 0.93) in women (using the gold standard, Sysmex KX-21),12 while in our study settings in rural India the mean Hb was 10.0 g/dL (using the gold standard, Sysmex XP-100). Similarly, the mean Hb in the French study was 13.2 g/dL (95% CI 11.9 to 14.3),1 and in the Italian study the boxplot indicated a mean Hb of 14.0 g/dL 15.…”

“…Second, our study recorded a good response rate (96.8%), with only seven eligible women declining to participate. Lastly, the non-invasive readings were obtained in accordance with the manufacturer's guidelines, and none of our subjects had thumb deformity, infection, ulcerations, oedema or skin colourants such as henna (locally known as Mehndi) 12. However, a technical failure of the non-invasive sensor occurred twice during the study, which delayed data collection, and caused the loss of two samples as mentioned before.…”

“…Previously published studies of the NBM 200 sensor (table 2) have been mostly conducted in prospective blood donors,5 6 12 14 15 in whom Hb is likely to be higher than in the general population. Moreover, the two Indian studies outlined earlier had fewer than 7% women participants 5 6.…”

Poor Validity of Noninvasive Hemoglobin Measurements by Pulse Oximetry Compared with Conventional Absorptiometry in Children in Côte d'Ivoire

“…The current investigation was integrated into a larger study pertaining to efficacy, safety, and pharmacodynamics of praziquantel in preschool-aged (2-5 years) and schoolaged (6)(7)(8)(9)(10)(11)(12)(13)(14)(15) The study staff was skilled at both Hb measuring systems. The same study staff used the Hb-measuring devices throughout the study.…”

“…Several devices are now commercially available and have been studied in a variety of settings with somewhat mixed results when compared with both invasive point-of-care devices and venous blood samples processed on a laboratory analyzer. [11][12][13][14][15] A recent meta-analysis identified 39 relevant studies and concluded that noninvasive Masimo Pronto-7 ® devices provide an unbiased, pooled estimate of laboratory Hb, yet have lower precision and wider 95% limits of agreement than invasive HemoCue devices. 16 Representative data on anemia are sparse in settings where anemia is most prevalent and particularly in settings without clinical facilities, where noninvasive methods are welcomed by both patients and medical personnel.…”