Comparison of three methods for the estimation of the pituitary gland volume using magnetic resonance imaging: a stereological study

Ertekın, Tolga; Acer, Niyazi; Turgut, Ahmet Tuncay; Aycan, Kenan; Özçelik, Özlem; Turğut, Mehmet

doi:10.1007/s11102-010-0254-3

Cited by 39 publications

(26 citation statements)

References 44 publications

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“…A comparison of the mean TIV from our study and other studies in other populations showed mild to moderate variation in values which probably due to differences geographical location and race as reported in literature [3,4]. The differences in our values from that of Odokuma et al [2] from the same Igbo population may be due to the methodology (anthropometry) which may have overestimated the TIV as affirmed by other authors [3,14,20]. Anthropometry overestimates the TIV due to contributions from the subject's hair, scalp and cranium.…”

Section: Discussionsupporting

confidence: 69%

Assessment of the Total Intra-Cranial Volume of the Igbo Population of Nigeria Using Computed Tomography

Onwuzu¹

2017

RST

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Abstract:Total intra-cranial volume (TIV) of the Igbo population of Nigeria was carried out using stereology technique. A total of 329 adult subjects of Igbo ethnic group with no cranial and brain abnormalities aged between 18 and 87 years were enlisted into the study (males: 193 and females: 136). They were scanned with a helical dual detector (GE Hi-Speed NX/i Series 8.1). Images were obtained with a slice thickness of 3 mm from the base of the skull to the vertex. Employing the Cavalieri's sections method with point counting, a grid with a separation distance of 2.4cm was superimposed on the sampled image sections to calculate the TIV of each subject. The mean TIV of males and females were 1298.44 ± 90.67 cm 3 and 1186.73 ± 79.05 cm 3 respectively. A comparison of the mean TIV from our study and other studies in other populations showed mild to moderate variation in values which probably due to differences geographical location and race. There was significant difference (p< 0.05) in the value of TIV in the Igbo population when compared with some other populations such as Turkey using the same methodology. Total intra-cranial volume estimate can be applied in forensic investigations to differentiate various ethnic nationalities, in addition to clinical assessment in quantitative imaging to assess disease progression.

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Section: Discussionsupporting

confidence: 69%

Assessment of the Total Intra-Cranial Volume of the Igbo Population of Nigeria Using Computed Tomography

Onwuzu¹

2017

RST

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“…The Cavalier theorem of systematic sampling in combination with point-counting is considered an unbiased, simple, inexpensive and efficient method and is ideally suitable for estimating volumes on magnetic resonance (MR) and CT images [3,7]. Volumetric analysis by CT and MR data using Cavalieri method are commonly used and its high rate of reproducibility and reliability has been verified in various studies [1,2,15]. Evaluation of the accuracy of acoustic rhinometry is more difficult because of the lack of a gold standard.…”

Section: Discussionmentioning

confidence: 99%

Age-related changes of nasal cavity and conchae volumes and volume fractions in children: a stereological study

et al. 2016

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“…The pituitary gland was considered small if the calculated size was below –2 SD and enlarged if the calculated size was greater than +2 SD when compared to age-adjusted normative values [22,23,24,25]. …”

Section: Methodsmentioning

confidence: 99%

Mutations and Pituitary Morphology in a Series of 82 Patients with <i>PROP1</i> Gene Defects

Obermannová

Pfaeffle²,

Zygmunt-Górska³

et al. 2011

Horm Res Paediatr

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Background/Aims: Defects of the PROP1 gene are the most prevalent genetic cause of combined pituitary hormone deficiency. Previous observations in affected patients have shown pituitary size ranging from hypoplasia to overt pituitary mass and evolution of size over the lifespan. Methods: We evaluated pituitary size and morphology in PROP1-mutation carriers who originated from Central and Eastern Europe. We analyzed 112 pituitary magnetic resonance imaging (MRI) scans from 82 patients (42 males) aged 2.5–72.7 (median 16.6) years from 60 kindreds. Results: Among the 120 independent PROP1 alleles, the most prevalent mutations were delGA301/302 (99 alleles) and delA150 (13 alleles). Median pituitary height at first MRI was 4.7 mm (range 1.0–20.7) and median volume was 127.6 mm³ (range 7.5–3,087.0). Pituitary size did not differ between sexes and did not correlate with hormonal phenotype, but significantly decreased with increasing age. However, evaluation of individual values suggested a biphasic mode with increasing volume during childhood, peak in adolescence, and subsequent regression in adulthood. Conclusion: Although pituitary size was increased in a number of PROP1-deficient patients, none of them suffered permanent damage from pituitary mass; therefore, any proposed surgery should be postponed as long as possible and ultimately may not be necessary due to the self-limiting nature of the pituitary enlargement.

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Comparison of three methods for the estimation of the pituitary gland volume using magnetic resonance imaging: a stereological study

Cited by 39 publications

References 44 publications

Assessment of the Total Intra-Cranial Volume of the Igbo Population of Nigeria Using Computed Tomography

Assessment of the Total Intra-Cranial Volume of the Igbo Population of Nigeria Using Computed Tomography

Age-related changes of nasal cavity and conchae volumes and volume fractions in children: a stereological study

Mutations and Pituitary Morphology in a Series of 82 Patients with <i>PROP1</i> Gene Defects

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