Comparison of Three Different Needles for Percutaneous Injections

Sudheendra, Deepak; Léger, Rosanne; Groppo, Eli R.; Sun, Dayin; Durrani, Amir K.; Neeman, Ziv; Wood, Bradford J.

doi:10.1007/s00270-005-0387-3

Cited by 14 publications

(13 citation statements)

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“…In the cluster group for small tumors (n=6), the difference between MIN and the straight-type needles increased. Notably, this result was similar to the results of a previous study comparing the distribution of drug injection into bovine liver with a conventional, three-side-hole and multipronged needles (9).…”

Section: Discussionsupporting

confidence: 90%

Local drug delivery to a human pancreatic tumor via a newly designed multiple injectable needle

Ohara

Kohno

Horibe

et al. 2012

Molecular and Clinical Oncology

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Endoscopic ultrasound-guided fine needle injection (EUS-FNI) has been proposed as a novel technique for local delivery of antitumor agents to refractory tumors, including pancreatic cancer. However, the present outcome of this strategy remains insufficient, and further improvements as well as novel agents and injection devices are required. The aim of the study was to determine the feasibility of a newly designed 'multiple injectable needle' (MIN) for EUS-FNI and the resulting improvements in the drug distribution to the tumor in comparison with straight-type needles. Human pancreatic cancer BxPC-3 cells or orthotopic tumor were transplanted subcutaneously into athymic rats. Ethanol was injected into subcutaneous tumors using a MIN or straight-type needle. Sequential sections of subcutaneous tumors were stained with hematoxylin and eosin, and tumors and injury areas were quantified using ImageJ software. In the orthotopic tumors, injection of the outer needle of the MIN, advancement of the inner needle and ethanol infusion were monitored by EUS. Injury volume of subcutaneous tumors using a MIN was greater than that with the straight-type needles, except for large tumors. Injecting process using MIN was monitored with endoscopic ultrasound (EUS). This study showed improvement in the drug distribution in a tumor, following injection with MIN compared to straight-type needles, suggesting the novel device to be feasible for use in EUS-FNI.

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Section: Discussionsupporting

confidence: 90%

Local drug delivery to a human pancreatic tumor via a newly designed multiple injectable needle

Ohara

Kohno

Horibe

et al. 2012

Molecular and Clinical Oncology

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“…However, in ex-vivo studies, end-hole needles were observed to form an elongated and nonuniform zone of distribution oriented along the direction of the needle. 53 Hence to target larger tumors (3–5cm), multiple needles must be placed across the tumor or the same needle can be repositioned and placed at different sites within the tumor to produce multiple overlapping zones of ablation. Treatment of these larger lesions is usually done in multiple sessions since each session is limited by the maximum dose of ethanol.…”

Section: Procedures Detailsmentioning

confidence: 99%

Indian College of Radiology and Imaging Guidelines on Interventions in Hepatocellular Carcinoma

Gupta

Kalra

Chaluvashetty

et al. 2022

Indian J Radiol Imaging

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Hepatocellular carcinoma (HCC) is one of the most common malignancies and a significant cause of cancer-related death. Treatment of HCC depends on the stage of the tumor. As many patients with HCC are not deemed fit for surgical resection or liver transplantation, locoregional therapies play an essential role in the management. Image-guided locoregional treatments include percutaneous ablative therapies and endovascular therapies. The choice of an individual or a combination of therapies is guided by the tumor and patient characteristics. As the outcomes of image-guided locoregional treatments depend on the ability to achieve necrosis of the entire tumor along with a safety margin around it, it is mandatory to follow standard guidelines. In this manuscript, we discuss in detail the various aspects of image-guided locoregional therapies to guide interventional radiologists involved in the care of patients with HCC.

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“…Conventional approaches such as localized injection techniques rely on spreading the therapeutic agent uniformly and in a great volume within the target. However, most of the percutaneous injection techniques have limitations such as the low absorption rate of the substance and the restricted amount of drug that has to be administered, often resulting in limiting the therapeutic effect 13 ; thus the improvement of the current needle designs and functionality must be considered 14 . New ways for delivery may be beneficial for treatment of soft tissue pathologies with localized and targeted strategies 15 in liver as well as other anatomical locations.…”

Section: Introductionmentioning

confidence: 99%

An Ultrasonically Actuated Needle Promotes the Transport of Nanoparticles and Fluids

Perra,

Hayward,

Pritzker

et al. 2021

Preprint

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Comparison of Three Different Needles for Percutaneous Injections

Cited by 14 publications

References 0 publications

Local drug delivery to a human pancreatic tumor via a newly designed multiple injectable needle

Local drug delivery to a human pancreatic tumor via a newly designed multiple injectable needle

Indian College of Radiology and Imaging Guidelines on Interventions in Hepatocellular Carcinoma

An Ultrasonically Actuated Needle Promotes the Transport of Nanoparticles and Fluids

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