Comparison of Three Commercially Available Assays for Measurement of Vitamin D

Yang, Dahae; Hwang, Hyunyong

doi:10.3343/lmo.2017.7.3.120

Cited by 3 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Breastfed infants are known to be vulnerable to VDD due to low vitamin D levels in human breastmilk and are dependent on maternal diet and factors affecting its endogenous synthesis [ 3 23 24 ]. In this study, several factors were found to be significant predictors of infant VDD, including infant age, sun index, and maternal vitamin D levels.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Status of Breastfed Filipino Infants Aged Less Than 6 Months in an Urban Community

Angeles

Retoriano

Arnaldo

et al. 2021

Pediatr Gastroenterol Hepatol Nutr

View full text Add to dashboard Cite

Purpose This study aimed to determine the serum 25-hydroxy-vitamin D (25(OH)D) status of breastfed infants less than six months old and their mothers, and factors affecting the status. Methods This cross-sectional study was done on breastfed, term, Filipino infants less than six months old who were seen at local health centers and clinics in an urban area. The serum 25(OH)D levels of these infants and their mothers were determined, and their demographic data, nutritional status, sun exposure behavior, and maternal vitamin D intake were analyzed for correlation using regression models. Results Among the 131 infants, 101 (77%) had vitamin D deficiency (VDD), which was defined as having 25(OH)D levels <37.5 nmol/L, and 13 (10%) had vitamin D insufficiency (VDI), with levels >37.5–50 nmol/L. Conversely, maternal VDD with levels <50 nmol/L was seen in 31 (24%) mothers and maternal VDI with levels 50–75 nmol/L, in 63 (48%) mothers. Infant age and maternal 25(OH)D status were independent predictors of infant VDD. Infants less than three months old were found to have a six-time increased risk of infant VDD ( p =0.004). Infants who had mothers with VDD had a six-time increased risk, whereas those with maternal VDI had a four-time increased risk of infant VDD ( p =0.049 and p =0.020, respectively). Conclusion Both infant and maternal VDD and VDI were seen to be highly prevalent in this tropical, urban community. Young infants and maternal VDD/VDI independently increased the risk of infant VDD, whereas lack of sun exposure of the mothers increased the risk for maternal VDI.

show abstract

Section: Discussionmentioning

confidence: 99%

Vitamin D Status of Breastfed Filipino Infants Aged Less Than 6 Months in an Urban Community

Angeles

Retoriano

Arnaldo

et al. 2021

Pediatr Gastroenterol Hepatol Nutr

View full text Add to dashboard Cite

show abstract

“…Furthermore, both methodologies use different pretreatment systems for the release of the 25(OH)D of the vitamin D binding protein, which could generate a different amount of 25(OH)D suitable for its measurement. In general, incomplete release has been suggested as a potential source of variability between different immunoassays for the determination of 25(OH)D, being implicated also different polymorphisms of this protein [ 21 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative study of two immunoassays used for the determination of serum vitamin D

Lahoz

Sánchez

Górriz

et al. 2021

Practical Laboratory Medicine

View full text Add to dashboard Cite

Objectives The best indicator of vitamin D level is the determination of serum 25-hydroxyvitamin D (25(OH)D). Due to the lack of standardization of the available methods, there are problems of precision and reproducibility in its measurement. The objective of this study was to compare the results of 25(OH)D concentration determined by two different immunoassay methods. Design and Methods: 25(OH)D was analyzed in 184 serum samples in an IDS-iSYS Multi-Discipline Automated System Analyzer (Vitro) and in an Alinity i automated Analyzer (Abbott). Then, results were compared. Three groups were considered: group of total patients, group with vitamin D supplements and group without treatment. Results Of the total patients, 52.7% received vitamin D supplements. The correlation coefficient of agreement for general group, supplementation group and group without supplementation was 0.92, 0.91 and 0.89, respectively. In all of them, a kappa index>0.75 was obtained. Conclusions The assays evaluated are not comparable to each other. Despite this, they show an excellent concordance in the evaluation of the vitamin D status.

show abstract

Performance Evaluation and Measurement Uncertainty Determination of the New Version of the Abbott ARCHITECT 25-OH Vitamin D 5P02 Assay

Lim

Park

Kweon

et al. 2018

American Journal of Clinical Pathology

View full text Add to dashboard Cite

Comparison of Three Commercially Available Assays for Measurement of Vitamin D

Cited by 3 publications

References 32 publications

Vitamin D Status of Breastfed Filipino Infants Aged Less Than 6 Months in an Urban Community

Vitamin D Status of Breastfed Filipino Infants Aged Less Than 6 Months in an Urban Community

Comparative study of two immunoassays used for the determination of serum vitamin D

Performance Evaluation and Measurement Uncertainty Determination of the New Version of the Abbott ARCHITECT 25-OH Vitamin D 5P02 Assay

Contact Info

Product

Resources

About