Comparison of three antigen detection methods for diagnosis and therapeutic monitoring of malaria: a field study from southern Vietnam

Huong, Nguyen Mai; Davis, Timothy M. E.; Hewitt, Sean; Huong, Nguyen Van; Uyen, Tran Thi; Nhan, Doan Hanh; Cong, Le

doi:10.1046/j.1365-3156.2002.00869.x

Cited by 104 publications

(97 citation statements)

References 12 publications

(22 reference statements)

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“…Such tests are known to lack specificity [28][29][30] : ours is no exception, and detailed results will be presented elsewhere (Laurent and others, in preparation ).…”

Section: Discussionmentioning

confidence: 92%

Community Effectiveness of Intermittent Preventive Treatment for Infants (IPTi) in Rural Southern Tanzania

Schellenberg¹,

Shirima²,

Maokola³

et al. 2010

The American Journal of Tropical Medicine and Hygiene

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“…Such tests are known to lack specificity [28][29][30] : ours is no exception, and detailed results will be presented elsewhere (Laurent and others, in preparation ).…”

Section: Discussionmentioning

confidence: 92%

Community Effectiveness of Intermittent Preventive Treatment for Infants (IPTi) in Rural Southern Tanzania

Schellenberg¹,

Shirima²,

Maokola³

et al. 2010

The American Journal of Tropical Medicine and Hygiene

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“…We calculated costs in Euros (as of August 2004, 1 Euro ¼ 1.219 USD) per 10 000 febrile patients consulting in a period of 1 month (Table 1). This unit rate seemed appropriate, as it allowed us to factor in timedependent costs (such as salaries), and since caseload is actually far higher in most serious epidemics (WHO 1998 Estimates of RDT sensitivity and specificity are the average of manufacturer specifications and the following studies: (Proux et al 2001;Guthmann et al 2002;Huong et al 2002;Singh et al 2002) RDT-based strategy 95% Specificity…”

Section: Parameter Inputsmentioning

confidence: 99%

Operational response to malaria epidemics: are rapid diagnostic tests cost‐effective?

Rolland¹,

Checchi

Pinoges³

et al. 2006

Tropical Med Int Health

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Summaryobjective To compare the cost-effectiveness of malaria treatment based on presumptive diagnosis with that of malaria treatment based on rapid diagnostic tests (RDTs).methods We calculated direct costs (based on experience from Ethiopia and southern Sudan) and effectiveness (in terms of reduced over-treatment) of a free, decentralised treatment programme using artesunate plus amodiaquine (AS + AQ) or artemether-lumefantrine (ART-LUM) in a Plasmodium falciparum epidemic. Our main cost-effectiveness measure was the incremental cost per false positive treatment averted by RDTs.results As malaria prevalence increases, the difference in cost between presumptive and RDT-based treatment rises. The threshold prevalence above which the RDT-based strategy becomes more expensive is 21% in the AS + AQ scenario and 55% in the ART-LUM scenario, but these thresholds increase to 58 and 70%, respectively, if the financing body tolerates an incremental cost of 1 € per false positive averted. However, even at a high (90%) prevalence of malaria consistent with an epidemic peak, an RDT-based strategy would only cost moderately more than the presumptive strategy: +29.9% in the AS + AQ scenario and +19.4% in the ART-LUM scenario. The treatment comparison is insensitive to the age and pregnancy distribution of febrile cases, but is strongly affected by variation in non-biomedical costs. If their unit price were halved, RDTs would be more cost-effective at a malaria prevalence up to 45% in case of AS + AQ treatment and at a prevalence up to 68% in case of ART-LUM treatment.conclusion In most epidemic prevalence scenarios, RDTs would considerably reduce over-treatment for only a moderate increase in costs over presumptive diagnosis. A substantial decrease in RDT unit price would greatly increase their cost-effectiveness, and should thus be advocated. A tolerated incremental cost of 1 € is probably justified given overall public health and financial benefits. The RDTs should be considered for malaria epidemics if logistics and human resources allow.

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“…Plasmodium vivax can also be detected by detection of antibodies against pan-malarial antigen in the absence of those against HRP-2 (ICT Malaria Pf/Pv). [12][13][14][15] The sensitivity and specificity of each of these tests have been assessed in a range of clinical situations.…”

Section: Introductionmentioning

confidence: 99%

Performance of the Optimal Test for Malaria Diagnosis Among Suspected Malaria Patients at the Rural Health Centers

Iqbal

Muneer

Khalid

et al. 2003

The American Journal of Tropical Medicine and Hygiene

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Abstract. The OptiMAL test detects both Plasmodium falciparum and P. vivax malaria infections. In this study, we evaluated the performance of the OptiMAL test at the Basic Health Units (BHUs) and the District Health Quarter (DHQ) Center in rural villages of Punjab, Pakistan that provide minimal health services. Two sets of blood specimens obtained from 930 suspected malaria patients attending these BHUs were tested at BHUs and the DHQ Center by microscopy and the OptiMAL test. At the BHUs, 231 (25%) of the patients were positive by microscopy and 278 (30%) patients tested positive by the OptiMAL test. At the DHQ Center, microscopic analysis of a second set of specimens from the same patients confirmed the malaria infection in 386 (42%) patients and the OptiMAL test result was positive in 300 (32%) patients. To determine the performance of OptiMAL test at the BHUs and the DHQ Center, all data were compared with microscopy results obtained at the DHQ Center. The OptiMAL test results for P. falciparum at the BHUs were comparable to those of the OptiMAL test at the DHQ Center. However, the sensitivity, positive predictive value (PPV), and negative predictive value (NPV) of the OptiMAL test were considerably lower for P. vivax infections than for P. falciparum infections, irrespective of whether the test was performed at the BHUs or at the DHQ Center (P. falciparum: sensitivity ‫ס‬ 78-85%, PPV ‫ס‬ 89-97%, NPV ‫ס‬ 96-98%; P. vivax: sensitivity ‫ס‬ 61-76%, PPV ‫ס‬ 88-95%, NPV ‫ס‬ 90-93%). The OptiMAL test also detected a number of false-positive and false-negative results at both the BHUs and the DHQ Center. The false-positive results ranged from 1% to 2%; however, the number of false-negative results was much higher (BHUs: P. falciparum ‫ס‬ 22%, P. vivax ‫ס‬ 39%; DHQ Center: P. falciparum ‫ס‬ 15%, P. vivax ‫ס‬ 24%). In conclusion, these results, when combined with other advantages of the OptiMAL test, suggest that this test can be used by relatively inexperienced persons to diagnose malaria infection in rural areas where facilities for microscopy are not available.

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Comparison of three antigen detection methods for diagnosis and therapeutic monitoring of malaria: a field study from southern Vietnam

Abstract: SummaryOBJECTIVES To compare the sensitivity, specificity and post-treatment persistence of three commonly used rapid antigen detection methods.

Cited by 104 publications

References 12 publications

Community Effectiveness of Intermittent Preventive Treatment for Infants (IPTi) in Rural Southern Tanzania

Community Effectiveness of Intermittent Preventive Treatment for Infants (IPTi) in Rural Southern Tanzania

Operational response to malaria epidemics: are rapid diagnostic tests cost‐effective?

Performance of the Optimal Test for Malaria Diagnosis Among Suspected Malaria Patients at the Rural Health Centers

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